Results 11 to 20 of about 50,133 (121)

Regulatory Mechanisms of Mitochondrial Autophagy: Lessons From Yeast

Frontiers in Plant Science, 2019
Mitochondria produce the majority of ATP required by cells via oxidative phosphorylation. Therefore, regulation of mitochondrial quality and quantity is important for maintaining cellular activities.
Kentaro Furukawa, Aleksei Innokentev, Tomotake Kanki   +2 more
doaj   +1 more source

Relationship between ferroptosis and mitophagy in acute lung injury: a mini-review [PDF]

PeerJ
Acute lung injury (ALI) is one of the most deadly and prevalent diseases in the intensive care unit. Ferroptosis and mitophagy are pathological mechanisms of ALI. Ferroptosis aggravates ALI, whereas mitophagy regulates ALI.
Yunhua Cheng, Liling Zhu, Shuangxiong Xie, Binyuan Lu, Xiaoyu Du, Guanjiang Ding, Yan Wang, Linchong Ma, Qingxin Li   +8 more
doaj   +2 more sources

Characterization of immune features and immunotherapy response in subtypes of hepatocellular carcinoma based on mitophagy

Frontiers in Immunology, 2022
Mitophagy is suggested to be involved in tumor initiation and development; however, mitophagy heterogeneity in hepatocellular carcinoma (HCC) and its association with immune status and prognosis remain unclear.
Yanan Wang, Boshizhang Peng, Chun Ning, Shuya He, Huayu Yang, Yilei Mao, Lejia Sun, Lejia Sun   +7 more
doaj   +1 more source

The role of the apoptosis-related protein BCL-B in the regulation of mitophagy in hepatic stellate cells during the regression of liver fibrosis

Experimental and Molecular Medicine, 2019
The clearance of activated hepatic stellate cells (HSCs) by apoptosis is critical for the reversibility of hepatic fibrosis. Mitochondrial homeostasis is regulated by mitophagy, which is an efficient way of clearing injured mitochondria that plays an ...
Qian Ding, Xiao-Li Xie, Miao-Miao Wang, Jie Yin, Jin-Mei Tian, Xiao-Yu Jiang, Di Zhang, Jing Han, Yun Bai, Zi-Jin Cui, Hui-Qing Jiang   +10 more
doaj   +1 more source

Hepatitis C Virus Non-Structural Protein 5A (NS5A) Disrupts Mitochondrial Dynamics and Induces Mitophagy

Cells, 2019
Mitophagy is a selective form of autophagy, targeting damaged mitochondria for lysosomal degradation. Although HCV infection has been shown to induce mitophagy, the precise underlying mechanism and the effector protein responsible remain unclear. Herein,
Alagie Jassey, Ching-Hsuan Liu, Chun A. Changou, Christopher D. Richardson, Hsue-Yin Hsu, Liang-Tzung Lin   +5 more
doaj   +1 more source

Atg43 tethers isolation membranes to mitochondria to promote starvation-induced mitophagy in fission yeast

eLife, 2020
Degradation of mitochondria through mitophagy contributes to the maintenance of mitochondrial function. In this study, we identified that Atg43, a mitochondrial outer membrane protein, serves as a mitophagy receptor in the model organism ...
Tomoyuki Fukuda, Yuki Ebi, Tetsu Saigusa, Kentaro Furukawa, Shun-ichi Yamashita, Keiichi Inoue, Daiki Kobayashi, Yutaka Yoshida, Tomotake Kanki   +8 more
doaj   +1 more source

The mitophagy pathway and its implications in human diseases

Signal Transduction and Targeted Therapy, 2023
Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell death and programmed apoptotic, and are crucial for cell metabolism and survival.
Shouliang Wang, Haijiao Long, Lianjie Hou, Baorong Feng, Zihong Ma, Ying Wu, Yu Zeng, Jiahao Cai, Da-wei Zhang, Guojun Zhao   +9 more
doaj   +1 more source

Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury

Journal of Translational Medicine, 2020
Background We have reported that polydatin (PD) alleviates mitochondrial dysfunction in rat models of sepsis-induced acute kidney injury (SI-AKI), but the mechanism is not well understood.
Youguang Gao, Xingui Dai, Yunfeng Li, Guicheng Li, Xianzhong Lin, Chenmu Ai, Yuanyuan Cao, Tao Li, Bo Lin   +8 more
doaj   +1 more source

Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy

Redox Biology, 2020
Both iron metabolism and mitophagy, a selective mitochondrial degradation process via autolysosomal pathway, are fundamental for the cellular well-being.
Hao Wu, Huifang Wei, Di Zhang, Sheikh Arslan Sehgal, Dejiu Zhang, Xiaohui Wang, Yan Qin, Lei Liu, Quan Chen   +8 more
doaj   +1 more source

Exploring mitophagy levels in Drosophila Malpighian tubules unveils the pivotal role of mitophagy in kidney function and diabetic kidney disease

Experimental and Molecular Medicine
Mitophagy has been implicated in kidney function and related diseases. However, a direct analysis of mitophagy in kidney models, including disease models, remains notably lacking.
Kang-Min Lee, Jihun Kim, Hye Lim Jung, Young Yeon Kim, Jihoon Lee, Yeon-Ju Lee, Eunhee Yoo, Hyi-Seung Lee, Jeanho Yun   +8 more
doaj   +1 more source