Results 11 to 20 of about 50,060 (264)
Chemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms
Pharmacological Research, 2023 Maintaining mitochondrial homeostasis is a potential therapeutic strategy for various diseases, including neurodegenerative diseases, cardiovascular diseases, metabolic disorders, and cancer. Selective degradation of mitochondria by autophagy (mitophagy)
Yu Dong +10 more
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Mitophagy in neurodegeneration and aging [PDF]
Frontiers in Genetics, 2012 Macroautophagy is a cellular catabolic process that involves the sequestration of cytoplasmic constituents into double-membrane vesicles known as autophagosomes, which subsequently fuse with lysosomes, where they deliver their cargo for degradation. The main physiological role of autophagy is to recycle intracellular components, under conditions of ...
Palikaras, Konstantinos +1 more
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Mitophagy Regulation Following Myocardial Infarction
Cells, 2022 Mitophagy, which mediates the selective elimination of dysfunctional mitochondria, is essential for cardiac homeostasis. Mitophagy is regulated mainly by PTEN-induced putative kinase protein-1 (PINK1)/parkin pathway but also by FUN14 domain-containing 1 (
Annie Turkieh +3 more
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Dysfunctional Mitochondria Clearance in Situ: Mitophagy in Obesity and Diabetes-Associated Cardiometabolic Diseases [PDF]
Diabetes & Metabolism JournalSeveral mitochondrial dysfunctions in obesity and diabetes include impaired mitochondrial membrane potential, excessive mitochondrial reactive oxygen species generation, reduced mitochondrial DNA, increased mitochondrial Ca2+ flux, and mitochondrial ...
Songling Tang +8 more
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A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy
Cell Reports, 2019 Summary: Degradation of mitochondria by selective autophagy, termed mitophagy, contributes to the control of mitochondrial quality. Bcl2-L-13 is a mammalian homolog of Atg32, which is an essential mitophagy receptor in yeast.
Tomokazu Murakawa +5 more
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Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN
Cells, 2022 The elimination of intracellular components by autophagy maintains metabolic homeostasis and is a quality-control pathway that enables organelle regeneration.
Po-Yuan Ke +2 more
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Mitophagy Transcriptome: Mechanistic Insights into Polyphenol‐Mediated Mitophagy [PDF]
Oxidative Medicine and Cellular Longevity, 2017 Mitochondria are important bioenergetic and signalling hubs critical for myriad cellular functions and homeostasis. Dysfunction in mitochondria is a central theme in aging and diseases. Mitophagy, a process whereby damaged mitochondria are selectively removed by autophagy, plays a key homeostatic role in mitochondrial quality control.
Sijie Tan, Esther Wong
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Regulatory Mechanisms of Mitochondrial Autophagy: Lessons From Yeast
Frontiers in Plant Science, 2019 Mitochondria produce the majority of ATP required by cells via oxidative phosphorylation. Therefore, regulation of mitochondrial quality and quantity is important for maintaining cellular activities.
Kentaro Furukawa +2 more
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Frontiers in Immunology, 2022 Mitophagy is suggested to be involved in tumor initiation and development; however, mitophagy heterogeneity in hepatocellular carcinoma (HCC) and its association with immune status and prognosis remain unclear.
Yanan Wang +7 more
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Relationship between ferroptosis and mitophagy in acute lung injury: a mini-review [PDF]
PeerJAcute lung injury (ALI) is one of the most deadly and prevalent diseases in the intensive care unit. Ferroptosis and mitophagy are pathological mechanisms of ALI. Ferroptosis aggravates ALI, whereas mitophagy regulates ALI.
Yunhua Cheng +8 more
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