Results 11 to 20 of about 63,946 (250)
Mitophagy in hepatic ischemia-reperfusion injury [PDF]
Jichu yixue yu linchuangIn case of hepatic ischemia-reperfusion injury (HIRI), mitophagy is induced by multiple pathways such as PINK1/Parkin and mitophagy receptor, which is closely related to mitochondrial dynamic related protein. Mitophagy is a double-edged sword.
ZHANG Xiangxin, LI Wen
doaj +2 more sources
Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf-1/ERK1/2/PINK1 Signaling Axis. [PDF]
Adv Sci (Weinh)Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Zhang L +9 more
europepmc +2 more sources
Deubiquitinating enzymes regulate PARK2-mediated mitophagy. [PDF]
, 2015 The selective degradation of mitochondria by the process of autophagy, termed mitophagy, is one of the major mechanisms of mitochondrial quality control. The best-studied mitophagy pathway is the one mediated by PINK1 and PARK2/Parkin.
Kim, Peter K +7 more
core +3 more sources
Compensatory Mitophagy via NEDD4/HIF-1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα. [PDF]
Adv Sci (Weinh)The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Feng D +15 more
europepmc +2 more sources
Flow Cytometer Monitoring of Bnip3- and Bnip3L/Nix-Dependent Mitophagy
, 2022 S.105-110Mitochondria are organelles with numerous vital roles in cellular metabolism. Impaired or damaged mitochondria are degraded in autophagolysosomes in a process known as mitophagy. Given the fundamental role of mitophagy in maintenance of cellular
Dikic, I., Novak, I., Sprung, M.
core +1 more source
Physiological functions of mitophagy [PDF]
, 2022 Mitochondria are vitally important organelles within our cells. In addition to being the key energy provider, they perform numerous other essential roles ranging from calcium homeostasis to iron metabolism.
Bishnu, Aniketh +3 more
core +1 more source
Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy [PDF]
, 2013 The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, apoptosis, and autophagy. STAT proteins undergo activation by phosphorylation at
Stephanou, A. +4 more
core +1 more source
Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin [PDF]
, 2017 Kazuhisa Kameyama,1,* Keiichi Motoyama,1,* Nao Tanaka,1 Yuki Yamashita,1 Taishi Higashi,1 Hidetoshi Arima1,2,* 1Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, 2Program for Leading Graduate Schools “HIGO (Health ...
Kazuhisa Kameyama +11 more
core +1 more source
Regulatory Mechanisms of Mitochondrial Autophagy: Lessons From Yeast
Frontiers in Plant Science, 2019 Mitochondria produce the majority of ATP required by cells via oxidative phosphorylation. Therefore, regulation of mitochondrial quality and quantity is important for maintaining cellular activities.
Kentaro Furukawa +2 more
doaj +1 more source
Frontiers in Immunology, 2022 Mitophagy is suggested to be involved in tumor initiation and development; however, mitophagy heterogeneity in hepatocellular carcinoma (HCC) and its association with immune status and prognosis remain unclear.
Yanan Wang +7 more
doaj +1 more source