Results 1 to 10 of about 23,205 (164)

Protective effects of Buyinqianzheng Formula on mitochondrial morphology by PINK1/Parkin pathway in SH-SY5Y cells induced by MPP+

Journal of Traditional Chinese Medical Sciences, 2020
Objective: Buyinqianzheng Formula (BYQZF) is clinically employed in traditional Chinese medicine to treat Parkinson’s disease (PD) by improving mitochondrial dysfunction.
Haojie Ma, Zhenyu Guo, Cong Gai, Cuicui Cheng, Jinkun Zhang, Yuxin Zhang, Luping Yang, Wandi Feng, Yushan Gao, Hongmei Sun   +9 more
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Role of mitophagy in spinal cord ischemia-reperfusion injury

Neural Regeneration Research
Spinal cord ischemia-reperfusion injury, a severe form of spinal cord damage, can lead to sensory and motor dysfunction. This injury often occurs after traumatic events, spinal cord surgeries, or thoracoabdominal aortic surgeries.
Yanni Duan, Fengguang Yang, Yibao Zhang, Mingtao Zhang, Yujun Shi, Yun Lang, Hongli Sun, Xin Wang, Hongyun Jin, Xuewen Kang   +9 more
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BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation.

PLoS ONE, 2014
Mutations in PTEN-induced kinase 1 (PINK1) gene cause PARK6 familial Parkinsonism, and loss of the stability of PINK1 may also contribute to sporadic Parkinson's disease (PD).
Xuejing Wang, Jifeng Guo, Erkang Fei, Yingfeng Mu, Shuang He, Xiangqian Che, Jieqiong Tan, Kun Xia, Zhuohua Zhang, Guanghui Wang, Beisha Tang   +10 more
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The role of mitophagy in periodontitis bone tissue

Kouqiang hemian waike zazhi
[Objective:] To investigate changes in mitophagy levels in bone tissue during periodontitis in mice and to explore the effects of lipopolysaccharide (LPS)-induced mitophagy on the osteogenic differentiation capacity of mouse embryonic osteoblast ...
CAI Yuyi, WANG Haicheng, SUN Bin, XU Yifan, WANG Zuolin   +4 more
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The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.

PLoS Genetics, 2010
PTEN-induced kinase 1 (PINK1), which is required for mitochondrial homeostasis, is a gene product responsible for early-onset Parkinson's disease (PD).
Yuzuru Imai, Tomoko Kanao, Tomoyo Sawada, Yoshito Kobayashi, Yasuhiro Moriwaki, Yosuke Ishida, Kohsuke Takeda, Hidenori Ichijo, Bingwei Lu, Ryosuke Takahashi   +9 more
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PINK1 mutants associated with recessive Parkinson’s disease are defective in inhibiting mitochondrial release of cytochrome c

Neurobiology of Disease, 2007
Mutations in PTEN-induced kinase 1 (PINK1) gene cause recessive familial type 6 of Parkinson’s disease (PARK6). We investigated molecular mechanisms underlying PINK1 neuroprotective function and PARK6 mutation-induced loss of PINK1 function ...
Hung-Li Wang, An-Hsun Chou, Tu-Hsueh Yeh, Allen H. Li, Ying-Ling Chen, Yu-Li Kuo, Shu-Ru Tsai, Szu-Tzu Yu   +7 more
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PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1.

PLoS Biology, 2007
Mutations in the PTEN induced putative kinase 1 (PINK1) gene cause an autosomal recessive form of Parkinson disease (PD). So far, no substrates of PINK1 have been reported, and the mechanism by which PINK1 mutations lead to neurodegeneration is unknown ...
Julia W Pridgeon, James A Olzmann, Lih-Shen Chin, Lian Li   +3 more
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PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes.

PLoS ONE, 2015
Myocyte function and survival relies on the maintenance of a healthy population of mitochondria. The PINK1/Parkin pathway plays an important role in clearing defective mitochondria via autophagy in cells.
Dieter A Kubli, Melissa Q Cortez, Alexandra G Moyzis, Rita H Najor, Youngil Lee, Åsa B Gustafsson   +5 more
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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

Neural Regeneration Research
The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.
Yanting Liu, Wei Huang, Jiayi Wen, Xin Xiong, Ting Xu, Qi Wang, Xiusheng Chen, Xianxian Zhao, Shihua Li, Xiaojiang Li, Weili Yang   +10 more
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PINK1 Overexpression Promotes Cell Migration and Proliferation via Regulation of Autophagy and Predicts a Poor Prognosis in Lung Cancer Cases

Cancer Management and Research, 2020
Xiao Lu,1,* Quan-Xing Liu,1,* Jiao Zhang,1 Dong Zhou,1 Gui-Xue Yang,1 Man-Yuan Li,1 Yuan Qiu,2 Qian Chen,3 Hong Zheng,1 Ji-Gang Dai1 1Department of Thoracic Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, People’s Republic of ...
Lu X, Liu QX, Zhang J, Zhou D, Yang GX, Li MY, Qiu Y, Chen Q, Zheng H, Dai JG   +9 more
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