Results 1 to 10 of about 37,135 (331)

Structural determinants of PINK1 topology and dual subcellular distribution

BMC Cell Biology, 2010
Background PINK1 is a mitochondria-targeted kinase that constitutively localizes to both the mitochondria and the cytosol. The mechanism of how PINK1 achieves cytosolic localization following mitochondrial processing remains unknown.
Kang Un, Lin William
doaj   +2 more sources

PINK1/PARKIN signalling in neurodegeneration and neuroinflammation [PDF]

Acta Neuropathologica Communications, 2020
Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson’s disease (PD).
Peter M. J. Quinn, P. Moreira, A. Ambrósio, C. H. Alves   +3 more
semanticscholar   +6 more sources

Structural mechanisms of mitochondrial quality control mediated by PINK1 and parkin.

Journal of Molecular Biology, 2023
Parkinson's disease (PD) is the second most common neurodegenerative disease and represents a looming public health crisis as the global population ages.
J. Trempe, K. Gehring
semanticscholar   +1 more source

PINK1/Parkin-Mediated Mitochondrial Autophagy Participates in H2O2-Induced Abnormal Proliferation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis

Journal of Inflammation Research, 2023
Gaoyuan Wang,1 Xiaoyu Chen,2 Yubao Shao,2 Bin Xu1 1Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China; 2Department of Histology and Embryology, Anhui Medical University, Hefei ...
Wang G, Chen X, Shao Y, Xu B
doaj  

Inhibition of PINK1 senses ROS signaling to facilitate neuroblastoma cell pyroptosis

Autophagy
Mitochondria serve as the primary source of intracellular reactive oxygen species (ROS), which play a critical role in orchestrating cell death pathways such as pyroptosis in various types of cancers.
Yuyuan Zhu, Min Cao, Yancheng Tang, Yi-Fan Liu, Haiji Wang, Jiaqi Qi, Cainian Huang, Chenghao Yan, Xu Liu, Sijia Jiang, Yufei Luo, Shao-Gui Wang, Bo Zhou, Hao-Dong Xu, Ying-ying Lu, Liming Wang   +15 more
semanticscholar   +1 more source

Novel insight into PINK1/parkin-associated autophagy implicated in Parkinson disease

Translational Neuroscience
Parkinson disease (PD) and its variants pose a dramatic burden on patients, families and society. Deciphering the mechanistic underpinnings of PD are critical goals of researchers to develop new therapeutic approaches.
Stegmüller Judith
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The Effect of Combined Resistance-Aerobic Training Along with Olive Oil Consumption on some Genes Involved in Apoptosis and the Balance of Induced Parkinsonian Rats

Journal of Ardabil University of Medical Sciences, 2022
Background & objectives: Parkinson's disease is a progressive neurological disorder associated with the destruction of dopaminergic neurons in the substantia nigra. Physical exercise can control the risk of neuronal damage.
Mansooreh Shamsi Soshab, Alireza Elmieh, Ramin Shabani   +2 more
doaj  

Parkin and PINK1 mitigate STING-induced inflammation

Nature, 2018
Although serum from patients with Parkinson’s disease contains elevated levels of numerous pro-inflammatory cytokines including IL-6, TNF, IL-1β, and IFNγ, whether inflammation contributes to or is a consequence of neuronal loss remains unknown1 ...
Danielle A. Sliter, Jennifer S. Martinez, Ling Hao, Xi Chen, Nuo Sun, Tara D. Fischer, Jonathon L. Burman, Yan Li, Zhe Zhang, Derek P. Narendra, H. Cai, M. Borsche, C. Klein, R. Youle   +13 more
semanticscholar   +1 more source

Mitochondrial ROS driven by NOX4 upregulation promotes hepatocellular carcinoma cell survival after incomplete radiofrequency ablation by inducing of mitophagy via Nrf2/PINK1

Journal of Translational Medicine, 2023
Background The recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains a major clinical problem. Cells that survive the sublethal heat stress that is induced by incomplete RFA are the main source of HCC relapse.
Chao Peng, Xi Li, Feng Ao, Ting Li, Jing Guo, Junfeng Liu, Xiaoting Zhang, Jinyan Gu, Jun-Jie Mao, Bin Zhou   +9 more
semanticscholar   +1 more source

Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury.

PLoS ONE, 2013
ObjectivesMutations in PTEN inducible kinase-1 (PINK1) induce mitochondrial dysfunction in dopaminergic neurons resulting in an inherited form of Parkinson's disease. Although PINK1 is present in the heart its exact role there is unclear. We hypothesized
Hilary K Siddall, Derek M Yellon, Sang-Bing Ong, Uma A Mukherjee, Niall Burke, Andrew R Hall, Plamena R Angelova, Marthe H R Ludtmann, Emma Deas, Sean M Davidson, Mihaela M Mocanu, Derek J Hausenloy   +11 more
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