Results 41 to 50 of about 23,381 (243)

Structural determinants of PINK1 topology and dual subcellular distribution

BMC Cell Biology, 2010
Background PINK1 is a mitochondria-targeted kinase that constitutively localizes to both the mitochondria and the cytosol. The mechanism of how PINK1 achieves cytosolic localization following mitochondrial processing remains unknown.
Kang Un, Lin William
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Function and Characteristics of PINK1 in Mitochondria [PDF]

Oxidative Medicine and Cellular Longevity, 2013
Mutations in phosphatase and tensin homologue-induced kinase 1 (PINK1) cause recessively inherited Parkinson’s disease, a neurodegenerative disorder linked to mitochondrial dysfunction. Studies support the notion of neuroprotective roles for the PINK1, as it protects cells from damage-mediated mitochondrial dysfunction, oxidative stress, and cell ...
Satoru Matsuda, Yasuko Kitagishi, Mayumi Kobayashi   +2 more
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Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury.

PLoS ONE, 2013
ObjectivesMutations in PTEN inducible kinase-1 (PINK1) induce mitochondrial dysfunction in dopaminergic neurons resulting in an inherited form of Parkinson's disease. Although PINK1 is present in the heart its exact role there is unclear. We hypothesized
Hilary K Siddall, Derek M Yellon, Sang-Bing Ong, Uma A Mukherjee, Niall Burke, Andrew R Hall, Plamena R Angelova, Marthe H R Ludtmann, Emma Deas, Sean M Davidson, Mihaela M Mocanu, Derek J Hausenloy   +11 more
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Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells

Open Biology, 2022
Autosomal recessive mutations in the PINK1 gene are causal for Parkinson's disease (PD). PINK1 encodes a mitochondrial localized protein kinase that is a master-regulator of mitochondrial quality control pathways.
Poonam Kakade, Hina Ojha, Olawale G. Raimi, Andrew Shaw, Andrew D. Waddell, James R. Ault, Sophie Burel, Kathrin Brockmann, Atul Kumar, Mohd Syed Ahangar, Ewelina M. Krysztofinska, Thomas Macartney, Richard Bayliss, Julia C. Fitzgerald, Miratul M. K. Muqit   +14 more
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Regulation of parkin and PINK1 by neddylation [PDF]

Human Molecular Genetics, 2012
Neddylation is a posttranslational modification that plays important roles in regulating protein structure and function by covalently conjugating NEDD8, an ubiquitin-like small molecule, to the substrate. Here, we report that Parkinson's disease (PD)-related parkin and PINK1 are NEDD8 conjugated.
Yeun Su, Choo, Georg, Vogler, Danling, Wang, Sreehari, Kalvakuri, Anton, Iliuk, W Andy, Tao, Rolf, Bodmer, Zhuohua, Zhang   +7 more
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Vivid views of the PINK1 protein [PDF]

Nature, 2017
Structures of an unusual enzymatic domain in PINK1 provide insights into how this protein regulates the function of organelles called mitochondria, and how mutations in PINK1 contribute to Parkinson’s disease. Structures of an unusual enzymatic domain in PINK1 provide insights into how this protein regulates the function of organelles called ...
Salima, Daou, Frank, Sicheri
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Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila

Cell Reports, 2021
Summary: The maintenance of mitochondrial homeostasis requires PTEN-induced kinase 1 (PINK1)-dependent mitophagy, and mutations in PINK1 are associated with Parkinson’s disease (PD). PINK1 is also downregulated in tumor cells with PTEN mutations. However,
Yongchao Han, Na Zhuang, Tao Wang
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Pink1, the first ubiquitin kinase [PDF]

The EMBO Journal, 2014
Pink1 and Parkin, identified through studies of hereditary early onset Parkinson's disease, are involved in mitochondria quality control. Parkin E3 ubiquitin ligase activity is activated by Pink1 kinase activity, although the mechanism is still elusive. Three recent reports uncover a surprising mechanism in which Pink1 directly phosphorylates ubiquitin
Xinde, Zheng, Tony, Hunter
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A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit

Cell Reports, 2023
Summary: Mechanisms that prevent accidental activation of the PINK1/Parkin mitophagy circuit on healthy mitochondria are poorly understood. On the surface of damaged mitochondria, PINK1 accumulates and acts as the input signal to a positive feedback loop
Christopher S. Waters, Sigurd B. Angenent, Steven J. Altschuler, Lani F. Wu   +3 more
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PINK1 mutations and parkinsonism [PDF]

Neurology, 2008
PINK1 loss-of-function causes recessive, early-onset parkinsonism. In Tunisia there is a high rate of consanguineous marriage but PINK1 carrier frequency and disease prevalence have yet to be assessed.The frequency of PINK1 mutations in familial parkinsonism, community-based patients with idiopathic Parkinson disease (PD) (non-familial PD), and control
L, Ishihara-Paul, M M, Hulihan, J, Kachergus, R, Upmanyu, L, Warren, R, Amouri, R, Elango, R K, Prinjha, A, Soto, M, Kefi, M, Zouari, S B, Sassi, S B, Yahmed, G, El Euch-Fayeche, P M, Matthews, L T, Middleton, R A, Gibson, F, Hentati, M J, Farrer   +18 more
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