Results 51 to 60 of about 23,205 (164)
Journal of Ardabil University of Medical Sciences, 2022 Background & objectives: Parkinson's disease is a progressive neurological disorder associated with the destruction of dopaminergic neurons in the substantia nigra. Physical exercise can control the risk of neuronal damage.
Mansooreh Shamsi Soshab +2 more
doaj
Mitochondrial-Dependent and Independent Functions of PINK1
Frontiers in Cell and Developmental Biology, 2022 PINK1 has been characterized as a mitochondrial kinase that can target to damaged mitochondria to initiate mitophagy, a process to remove unhealthy mitochondria for protecting neuronal cells.
Xiusheng Chen +4 more
doaj +1 more source
Identification of Ser465 as a novel PINK1 autophosphorylation site
Translational Neurodegeneration, 2017 Background PINK1 (PTEN-induced putative kinase 1) gene is the causal gene for recessive familial type 6 of Parkinson’s disease (PARK6), which is an early-onset autosomal recessive inherited neurodegenerative disease. PINK1 has been reported to exert both
Ji-feng Guo +7 more
doaj +1 more source
PLoS Genetics, 2010 Mutations in PINK1 and Parkin cause familial, early onset Parkinson's disease. In Drosophila melanogaster, PINK1 and Parkin mutants show similar phenotypes, such as swollen and dysfunctional mitochondria, muscle degeneration, energy depletion, and ...
Song Liu, Bingwei Lu
doaj +1 more source
PINK1 function in health and disease
EMBO Molecular Medicine, 2009 The role of mitochondria in sporadic Parkinson's disease (PD) has been debated for a little over 20 years since the description of complex I deficiency in the substantia nigra pars compacta (SNpc) of PD patients. However, the identification of recessive pathogenic mutations in the pink1 gene in familial PD cases firmly re-ignited interest in the ...
Deas, Emma +2 more
openaire +2 more sources
DISCOVERY OF A NEW ROLE FOR PINK1: PHOSPHORYLATION OF UBIQUITIN BY PINK1 ACTIVATES PARKIN [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 2014 Mutations in the PINK1 and Parkin genes are associated with autosomal-recessive Parkinson9s disease. PINK1 encodes a mitochondrial localized protein kinase and Parkin encodes an ubiquitin E3 ligase. Several lines of evidence indicate that the enzymes encoded by these genes function in a common signalling pathway.
A Kazlauskaite +9 more
openaire +1 more source
Autophagy and mitophagy in hepatocarcinogenesis
Molecular & Cellular Oncology, 2018 Autophagy is required for benign hepatic tumors to progress into malignant hepatocellular carcinoma. In our recent studies, we found that autophagy, or more specifically mitophagy, was required to suppress TP53 and induce the expression of the ...
Kai Liu +2 more
doaj +1 more source
PLoS ONE, 2016 Mutations in the gene encoding the mitochondrial kinase PINK1 cause early-onset familial Parkinson's disease. To understand the biological function of PINK1 and its role in the pathogenesis of Parkinson's disease, it is useful to study its kinase ...
Liesbeth Aerts +3 more
doaj +1 more source
Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking [PDF]
Biochemistry, 2009 Recessive mutations in Pink1 lead to a selective degeneration of dopaminergic neurons in the substantia nigra that is characteristic of Parkinson disease. Pink1 is a kinase that is targeted in part to mitochondria, and loss of Pink1 function can alter mitochondrial morphology and dynamics, thus supporting a link between mitochondrial dysfunction and ...
Andreas, Weihofen +4 more
openaire +2 more sources
Regulation of mitochondrial permeability transition pore by PINK1
Molecular Neurodegeneration, 2012 Background Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) have been linked to familial Parkinson’s disease, but the underlying pathogenic mechanism remains unclear.
Gautier Clement A +7 more
doaj +1 more source