Results 71 to 80 of about 23,381 (243)

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Measuring PINK1 Activity in Single Cells Using a PINK1 Kinase Activity Reporter

Bio-Protocol
Phosphatase and tensin homolog-induced kinase 1 (PINK1) is a serine/threonine kinase that plays a key role in mitophagy initiation. Loss-of-function autosomal recessive mutations in PINK1 cause early onset Parkinson’s disease (EOPD).
Katie Vineall, Danielle Schmitt
doaj   +1 more source

Inhalable ROS‐Responsive Nanospray Activates PPAR‐γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, Rong Li, Shenglin Luo   +11 more
wiley   +1 more source

Regulation of mitochondrial permeability transition pore by PINK1

Molecular Neurodegeneration, 2012
Background Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) have been linked to familial Parkinson’s disease, but the underlying pathogenic mechanism remains unclear.
Gautier Clement A, Giaime Emilie, Caballero Erica, Núñez Lucía, Song Zhiyin, Chan David, Villalobos Carlos, Shen Jie   +7 more
doaj   +1 more source

PINK1 phosphorylates ubiquitin predominantly in astrocytes [PDF]

npj Parkinson's Disease, 2019
AbstractLoss-of-function mutations in PINK1 are causally linked to recessively inherited Parkinson’s disease (PD), with marked loss of dopaminergic neurons in the substantia nigra that are required for normal movement. PINK1 is a nuclear-encoded mitochondrial-targeted kinase that phosphorylates a conserved serine at amino acid 65 (pS65) in ubiquitin as
Sandeep K. Barodia, Laura J. McMeekin, Rose B. Creed, Elijah K. Quinones, Rita M. Cowell, Matthew S. Goldberg   +5 more
openaire   +2 more sources

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Role of mitophagy in spinal cord ischemia-reperfusion injury

Neural Regeneration Research
Spinal cord ischemia-reperfusion injury, a severe form of spinal cord damage, can lead to sensory and motor dysfunction. This injury often occurs after traumatic events, spinal cord surgeries, or thoracoabdominal aortic surgeries.
Yanni Duan, Fengguang Yang, Yibao Zhang, Mingtao Zhang, Yujun Shi, Yun Lang, Hongli Sun, Xin Wang, Hongyun Jin, Xuewen Kang   +9 more
doaj   +1 more source

BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation.

PLoS ONE, 2014
Mutations in PTEN-induced kinase 1 (PINK1) gene cause PARK6 familial Parkinsonism, and loss of the stability of PINK1 may also contribute to sporadic Parkinson's disease (PD).
Xuejing Wang, Jifeng Guo, Erkang Fei, Yingfeng Mu, Shuang He, Xiangqian Che, Jieqiong Tan, Kun Xia, Zhuohua Zhang, Guanghui Wang, Beisha Tang   +10 more
doaj   +1 more source

Protective effects of Buyinqianzheng Formula on mitochondrial morphology by PINK1/Parkin pathway in SH-SY5Y cells induced by MPP+

Journal of Traditional Chinese Medical Sciences, 2020
Objective: Buyinqianzheng Formula (BYQZF) is clinically employed in traditional Chinese medicine to treat Parkinson’s disease (PD) by improving mitochondrial dysfunction.
Haojie Ma, Zhenyu Guo, Cong Gai, Cuicui Cheng, Jinkun Zhang, Yuxin Zhang, Luping Yang, Wandi Feng, Yushan Gao, Hongmei Sun   +9 more
doaj   +1 more source

PINK1 and Parkin to control mitochondria remodeling [PDF]

Anatomy & Cell Biology, 2010
Parkinson's disease (PD), one of the most common neurodegenerative diseases, is characterized by movement disorders and a loss of dopaminergic (DA) neurons. PD mainly occurs sporadically, but may also result from genetic mutations in several PD-linked genes.
Koh, Hyongjong, Chung, Jongkyeong
openaire   +2 more sources