Results 81 to 90 of about 38,037 (258)
Identification of Ser465 as a novel PINK1 autophosphorylation site
Translational Neurodegeneration, 2017 Background PINK1 (PTEN-induced putative kinase 1) gene is the causal gene for recessive familial type 6 of Parkinson’s disease (PARK6), which is an early-onset autosomal recessive inherited neurodegenerative disease. PINK1 has been reported to exert both
Ji-feng Guo +7 more
doaj +1 more source
Circadian Rhythm Abnormalities in Parkinson's Disease from Humans to Flies and Back [PDF]
, 2018 Clinical and research studies have suggested a link between Parkinson\u2019s disease (PD) and alterations in the circadian clock. Drosophila melanogaster may represent a useful model to study the relationship between the circadian clock and PD.
Bisaglia, Marco +3 more
core +1 more source
Regulation of PINK1-Parkin-mediated mitophagy [PDF]
Autophagy, 2011 Parkinson disease (PD) is a devastating disorder of the nervous system for which no cure exists. Although the exact mechanisms involved in the pathogenesis of PD are unclear, very recently, a novel cellular process has been identified that promises great future potential.
Springer, Wolfdieter, Kahle, Philipp J
openaire +3 more sources
Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity
Advanced Science, EarlyView.Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu +8 more
wiley +1 more source
PLoS Genetics, 2010 Mutations in PINK1 and Parkin cause familial, early onset Parkinson's disease. In Drosophila melanogaster, PINK1 and Parkin mutants show similar phenotypes, such as swollen and dysfunctional mitochondria, muscle degeneration, energy depletion, and ...
Song Liu, Bingwei Lu
doaj +1 more source
Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer disease [PDF]
, 2017 Alzheimer disease (AD), Frontotemporal lobar degeneration (FTD), Amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD) have a certain degree of clinical, pathological and molecular overlap.
Alexandra Medvedeva +17 more
core +4 more sources
Vivid views of the PINK1 protein [PDF]
Nature, 2017 Structures of an unusual enzymatic domain in PINK1 provide insights into how this protein regulates the function of organelles called mitochondria, and how mutations in PINK1 contribute to Parkinson’s disease. Structures of an unusual enzymatic domain in PINK1 provide insights into how this protein regulates the function of organelles called ...
Salima, Daou, Frank, Sicheri
openaire +2 more sources
Advanced Science, EarlyView.This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren +5 more
wiley +1 more source
Autophagy and mitophagy in hepatocarcinogenesis
Molecular & Cellular Oncology, 2018 Autophagy is required for benign hepatic tumors to progress into malignant hepatocellular carcinoma. In our recent studies, we found that autophagy, or more specifically mitophagy, was required to suppress TP53 and induce the expression of the ...
Kai Liu +2 more
doaj +1 more source
PLoS ONE, 2016 Mutations in the gene encoding the mitochondrial kinase PINK1 cause early-onset familial Parkinson's disease. To understand the biological function of PINK1 and its role in the pathogenesis of Parkinson's disease, it is useful to study its kinase ...
Liesbeth Aerts +3 more
doaj +1 more source