Results 1 to 10 of about 271,126 (314)

Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight

Biomolecules, 2022
Synucleinopathies are a group of neurodegenerative diseases, characterized by the abnormal accumulation of the protein alpha-synuclein (aSyn). aSyn is an intrinsically disordered protein that can adopt different aggregation states, some of which may be ...
Mohammed Al-Azzani, Annekatrin König, Tiago Fleming Outeiro   +2 more
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Mitochondrial Neurodegeneration [PDF]

Cells, 2022
Mitochondria are cytoplasmic organelles, which generate energy as heat and ATP, the universal energy currency of the cell. This process is carried out by coupling electron stripping through oxidation of nutrient substrates with the formation of a proton-based electrochemical gradient across the inner mitochondrial membrane.
Zeviani, Massimo, Viscomi, Carlo
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Rationale and design of the “NEurodegeneration: Traumatic brain injury as Origin of the Neuropathology (NEwTON)” study: a prospective cohort study of individuals at risk for chronic traumatic encephalopathy

Alzheimer’s Research & Therapy, 2022
Background Repetitive head injury in contact sports is associated with cognitive, neurobehavioral, and motor impairments and linked to a unique neurodegenerative disorder: chronic traumatic encephalopathy (CTE).
Suzan van Amerongen, Dewi K. Caton, Rik Ossenkoppele, Frederik Barkhof, Petra J. W. Pouwels, Charlotte E. Teunissen, Annemieke J. M. Rozemuller, Jeroen J. M. Hoozemans, Yolande A. L. Pijnenburg, Philip Scheltens, Everard G. B. Vijverberg   +10 more
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Severe CTE and TDP-43 pathology in a former professional soccer player with dementia: a clinicopathological case report and review of the literature

Acta Neuropathologica Communications, 2023
In the last decades, numerous post-mortem case series have documented chronic traumatic encephalopathy (CTE) in former contact-sport athletes, though reports of CTE pathology in former soccer players are scarce.
Suzan van Amerongen, Suzie Kamps, Kyra K. M. Kaijser, Yolande A. L. Pijnenburg, Philip Scheltens, Charlotte E. Teunissen, Frederik Barkhof, Rik Ossenkoppele, Annemieke J. M. Rozemuller, Robert A. Stern, Jeroen J. M. Hoozemans, Everard G. B. Vijverberg   +11 more
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Nanomaterials and neurodegeneration [PDF]

Environmental and Molecular Mutagenesis, 2015
The increasing application of nanotechnology in various industrial, environmental, and human settings raises questions surrounding the potential adverse effects induced by nanosized materials to human health, including the possible neurotoxic and neuroinflammatory properties of those substances and their capability to induce neurodegeneration.
MIGLIORE, LUCIA, UBOLDI, CHIARA, DI BUCCHIANICO, SEBASTIANO, COPPEDE', FABIO   +3 more
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Transglutaminases and neurodegeneration [PDF]

Journal of Neurochemistry, 2009
AbstractTransglutaminases (TGs) are Ca2+‐dependent enzymes that catalyze a variety of modifications of glutaminyl (Q) residues. In the brain, these modifications include the covalent attachment of a number of amine‐bearing compounds, including lysyl (K) residues and polyamines, which serve to either regulate enzyme activity or attach the TG substrates ...
Thomas M, Jeitner, John T, Pinto, Boris F, Krasnikov, Mark, Horswill, Arthur J L, Cooper   +4 more
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Deubiquitinases in Neurodegeneration [PDF]

Cells, 2022
Ubiquitination refers to the conjugation of the ubiquitin protein (a small protein highly conserved among eukaryotes) to itself or to other proteins through differential use of ubiquitin’s seven internal linkage sites or the amino-terminal amino group. By creating different chain lengths, an enormous proteomic diversity may be formed.
Abudu I. Bello, Rituparna Goswami, Shelby L. Brown, Kara Costanzo, Taylor Shores, Shefaa Allan, Revan Odah, Ryan D. Mohan   +7 more
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Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies

Cells, 2021
The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy pathology, is a phenomenon central to Parkinson’s disease (PD) pathogenesis.
Inês C. Brás, Tiago F. Outeiro
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Pharmacological Modulators of Tau Aggregation and Spreading

Brain Sciences, 2020
Tauopathies are neurodegenerative disorders characterized by the deposition of aggregates composed of abnormal tau protein in the brain. Additionally, misfolded forms of tau can propagate from cell to cell and throughout the brain.
Antonio Dominguez-Meijide, Eftychia Vasili, Tiago Fleming Outeiro   +2 more
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Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice

Acta Neuropathologica Communications, 2021
Introduction Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, vascular impairment is also a hallmark event of the pathological ...
Yingxi Wu, Haijian Wu, Jianxiong Zeng, Brock Pluimer, Shirley Dong, Xiaochun Xie, Xinying Guo, Tenghuan Ge, Xinyan Liang, Sudi Feng, Youzhen Yan, Jian-Fu Chen, Naomi Sta Maria, Qingyi Ma, Fernando Gomez-Pinilla, Zhen Zhao   +15 more
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