Results 1 to 10 of about 307,834 (316)

Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy

Nature, 2023
A study finds T cells in areas of tau, not amyloid, pathology in Alzheimer’s disease brain and mouse models, with their presence correlating with neuronal loss and their depletion, or that of microglia, preventing neurodegeneration and cognitive decline.
Jasmin Herz, Maxim Artyomov, David Holtzman   +2 more
exaly   +2 more sources

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia

Neuron, 2021
Summary The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer disease and directly influences tauopathy and tau-mediated neurodegeneration. ApoE4 has strong deleterious effects on both parameters.
Melissa Manis, Maxim Artyomov, Maud Gratuze   +2 more
exaly   +2 more sources

Role of neuroinflammation in neurodegeneration development

Signal Transduction and Targeted Therapy, 2023
Studies in neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and Amyotrophic lateral sclerosis, Huntington’s disease, and so on, have suggested that inflammation is not only a result of neurodegeneration but also a crucial ...
Weifeng Zhang, Dan Xiao, Q. Mao, Haibin Xia   +3 more
semanticscholar   +1 more source

Rationale and design of the “NEurodegeneration: Traumatic brain injury as Origin of the Neuropathology (NEwTON)” study: a prospective cohort study of individuals at risk for chronic traumatic encephalopathy

Alzheimer’s Research & Therapy, 2022
Background Repetitive head injury in contact sports is associated with cognitive, neurobehavioral, and motor impairments and linked to a unique neurodegenerative disorder: chronic traumatic encephalopathy (CTE).
Suzan van Amerongen, Dewi K. Caton, Rik Ossenkoppele, Frederik Barkhof, Petra J. W. Pouwels, Charlotte E. Teunissen, Annemieke J. M. Rozemuller, Jeroen J. M. Hoozemans, Yolande A. L. Pijnenburg, Philip Scheltens, Everard G. B. Vijverberg   +10 more
doaj   +1 more source

Severe CTE and TDP-43 pathology in a former professional soccer player with dementia: a clinicopathological case report and review of the literature

Acta Neuropathologica Communications, 2023
In the last decades, numerous post-mortem case series have documented chronic traumatic encephalopathy (CTE) in former contact-sport athletes, though reports of CTE pathology in former soccer players are scarce.
Suzan van Amerongen, Suzie Kamps, Kyra K. M. Kaijser, Yolande A. L. Pijnenburg, Philip Scheltens, Charlotte E. Teunissen, Frederik Barkhof, Rik Ossenkoppele, Annemieke J. M. Rozemuller, Robert A. Stern, Jeroen J. M. Hoozemans, Everard G. B. Vijverberg   +11 more
doaj   +1 more source

Loss of Fatty Acid Degradation by Astrocytic Mitochondria Triggers Neuroinflammation and Neurodegeneration

Nature Metabolism, 2023
Mi, Qi et al. identify a mechanism through which defective oxidative phosphorylation in astrocytes deregulates astroglial lipid homeostasis and subsequently impacts neurons and microglial cells, thus triggering neuronal damage and microglial reactivity ...
Yashi Mi, Guoyuan Qi, F. Vitali, Yuan Shang, A. Raikes, Tian Wang, Yan Jin, R. Brinton, Haiwei Gu, F. Yin   +9 more
semanticscholar   +1 more source

Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight

Biomolecules, 2022
Synucleinopathies are a group of neurodegenerative diseases, characterized by the abnormal accumulation of the protein alpha-synuclein (aSyn). aSyn is an intrinsically disordered protein that can adopt different aggregation states, some of which may be ...
Mohammed Al-Azzani, Annekatrin König, Tiago Fleming Outeiro   +2 more
doaj   +1 more source

cGAS–STING drives ageing-related inflammation and neurodegeneration

Nature, 2023
The cGAS–STING signalling pathway is a critical driver of chronic inflammation and functional decline during ageing, and could be targeted to halt neurodegenerative processes during old age.
M. F. Gulen, Natasha Samson, Alexander Keller, Marius Schwabenland, Chong Liu, S. Glück, Vivek V. Thacker, L. Favre, Bastien Mangeat, Lona J Kroese, P. Krimpenfort, M. Prinz, A. Ablasser   +12 more
semanticscholar   +1 more source

ApoE isoform and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy

Science, 2023
Tau-mediated neurodegeneration is a hallmark of Alzheimer’s disease. Primary tauopathies are characterized by pathological tau accumulation and neuronal and synaptic loss.
D. Seo, D. O’Donnell, Nimansha Jain, Jason D. Ulrich, Jasmin Herz, Yuhao Li, Mackenzie Lemieux, Jiye Cheng, Hao Hu, J. R. Serrano, Xin-Chen Bao, Emily Franke, Maria Karlsson, Martin F. Meier, Su Deng, Chandani Desai, H. Dodiya, Janaki Lelwala‐Guruge, S. Handley, J. Kipnis, S. Sisodia, Jeffrey I. Gordon, D. Holtzman   +22 more
semanticscholar   +1 more source

Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration

Nature Neuroscience, 2022
Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson’s disease (PD). Iron-loaded microglia are frequently found in affected brain regions, but how iron accumulation influences microglia physiology and ...
Sean K. Ryan, Matija Zelic, Yingnan Han, E. Teeple, Luoman Chen, M. Sadeghi, S. Shankara, Lilu Guo, Congmei Li, Fabrizio Pontarelli, Elizabeth H. Jensen, Ashley L. Comer, Dinesh Kumar, Mindy Zhang, Joseph Gans, Bailin Zhang, J. Proto, Jacqueline Saleh, James C. Dodge, Virginia Savova, D. Rajpal, D. Ofengeim, Timothy R. Hammond   +22 more
semanticscholar   +1 more source