Results 1 to 10 of about 300,100 (258)

Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight

Biomolecules, 2022
Synucleinopathies are a group of neurodegenerative diseases, characterized by the abnormal accumulation of the protein alpha-synuclein (aSyn). aSyn is an intrinsically disordered protein that can adopt different aggregation states, some of which may be ...
Mohammed Al-Azzani, Annekatrin König, Tiago Fleming Outeiro   +2 more
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Rationale and design of the “NEurodegeneration: Traumatic brain injury as Origin of the Neuropathology (NEwTON)” study: a prospective cohort study of individuals at risk for chronic traumatic encephalopathy

Alzheimer’s Research & Therapy, 2022
Background Repetitive head injury in contact sports is associated with cognitive, neurobehavioral, and motor impairments and linked to a unique neurodegenerative disorder: chronic traumatic encephalopathy (CTE).
Suzan van Amerongen, Dewi K. Caton, Rik Ossenkoppele, Frederik Barkhof, Petra J. W. Pouwels, Charlotte E. Teunissen, Annemieke J. M. Rozemuller, Jeroen J. M. Hoozemans, Yolande A. L. Pijnenburg, Philip Scheltens, Everard G. B. Vijverberg   +10 more
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Severe CTE and TDP-43 pathology in a former professional soccer player with dementia: a clinicopathological case report and review of the literature

Acta Neuropathologica Communications, 2023
In the last decades, numerous post-mortem case series have documented chronic traumatic encephalopathy (CTE) in former contact-sport athletes, though reports of CTE pathology in former soccer players are scarce.
Suzan van Amerongen, Suzie Kamps, Kyra K. M. Kaijser, Yolande A. L. Pijnenburg, Philip Scheltens, Charlotte E. Teunissen, Frederik Barkhof, Rik Ossenkoppele, Annemieke J. M. Rozemuller, Robert A. Stern, Jeroen J. M. Hoozemans, Everard G. B. Vijverberg   +11 more
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Beyond the Primary Infarction: Focus on Mechanisms Related to Secondary Neurodegeneration after Stroke [PDF]

, 2022
Recently, a growing body of evidence has indicated that secondary neurodegeneration after stroke occurs at remote regions of the brain that are connected to the primary infarction site [...
Lin Kooi Ong, Ong, Lin Kooi
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Neurodegeneration [PDF]

, 2022
Wave V measures of neurodegeneration were based on venous blood collected via phlebotomy. The blood was collected by field examiners (FEs) certified in phlebotomy, chilled at 4°C during the remainder of the home exam, centrifuged immediately afterward ...
Whitsel, Eric A., O'Hara, Rick, Harris, Kathleen Mullan, Qu, Lixin, Angel, Robert, Carrier, Kathryn   +5 more
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Recent Advances in Neurodegeneration [PDF]

, 2019
This Edited Volume Recent Advances in Neurodegeneration is a is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of neurodegeneration.

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Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies

Cells, 2021
The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy pathology, is a phenomenon central to Parkinson’s disease (PD) pathogenesis.
Inês C. Brás, Tiago F. Outeiro
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Pharmacological Modulators of Tau Aggregation and Spreading

Brain Sciences, 2020
Tauopathies are neurodegenerative disorders characterized by the deposition of aggregates composed of abnormal tau protein in the brain. Additionally, misfolded forms of tau can propagate from cell to cell and throughout the brain.
Antonio Dominguez-Meijide, Eftychia Vasili, Tiago Fleming Outeiro   +2 more
doaj   +1 more source

Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice

Acta Neuropathologica Communications, 2021
Introduction Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, vascular impairment is also a hallmark event of the pathological ...
Yingxi Wu, Haijian Wu, Jianxiong Zeng, Brock Pluimer, Shirley Dong, Xiaochun Xie, Xinying Guo, Tenghuan Ge, Xinyan Liang, Sudi Feng, Youzhen Yan, Jian-Fu Chen, Naomi Sta Maria, Qingyi Ma, Fernando Gomez-Pinilla, Zhen Zhao   +15 more
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Insights into molecular mechanisms of disease in Neurodegeneration with Brain Iron Accumulation; unifying theories. [PDF]

, 2016
Neurodegeneration with brain iron accumulation (NBIA) is a group of disorders characterised by dystonia, parkinsonism and spasticity. Iron accumulates in the basal ganglia and may be accompanied by Lewy bodies, axonal swellings and hyperphosphorylated ...
Arber, C, Houlden, H, H. Houlden, C. E. Arber, S. Wray, Wray, S, A. Li, Li, A   +7 more
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