Results 41 to 50 of about 93,036 (258)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A manifesto for Alzheimer’s disease drug discovery in the era of disease-modifying therapies

Molecular Neurodegeneration
After decades of disappointment, three disease-modifying therapies for Alzheimer’s disease (AD) have been approved since 2021. Burgeoning clinical data on these amyloid β-protein (Aβ) targeting drugs validate the amyloid cascade hypothesis as a molecular
Heike Hering, Thierry Bussiere, Chia-Chen Liu, Kelly E. Glajch, Andreas Weihofen, Jane Grogan, Dominic M. Walsh   +6 more
doaj   +1 more source

Stress granules formation in HEI-OC1 auditory cells and in H4 human neuroglioma cells secondary to cisplatin exposure

Cell Stress
Stress granules (SGs) are highly dynamic micromolecular membraneless condensates that generate in cells subjected to stress. Formed from pools of untranslating messenger ribonucleoproteins (RNP), SGs dynamics constitute vital processes essential for cell
Hebatallah Abdelrasol, Avika Chopra, Liana Shvachiy, Dirk Beutner, Tiago F Outeiro, Cristian Setz   +5 more
doaj   +1 more source

Mossy cell hypertrophy and synaptic changes in the hilus following mild diffuse traumatic brain injury in pigs

Journal of Neuroinflammation, 2020
Background Each year in the USA, over 2.4 million people experience mild traumatic brain injury (TBI), which can induce long-term neurological deficits.
Michael R. Grovola, Nicholas Paleologos, Kathryn L. Wofford, James P. Harris, Kevin D. Browne, Victoria Johnson, John E. Duda, John A. Wolf, D. Kacy Cullen   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Autophagy and Neurodegeneration [PDF]

Autophagy, 2006
The proteasome and lysosome are sophisticated apparatuses capable of shredding unnecessary proteins in eukaryotic cells. The proteasome and its partner ubiquitin (which functions as a destination signal for proteolysis) play crucial roles in selective breakdown of not only short-lived regulatory proteins but also abnormal proteins that need to be ...
Masaaki, Komatsu, Eiki, Kominami, Keiji, Tanaka   +2 more
openaire   +5 more sources

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease [PDF]

, 2009
The role of microglial cells in the pathogenesis of Alzheimer’s disease (AD) neurodegeneration is unknown. Although several works suggest that chronic neuroinflammation caused by activated microglia contributes to neurofibrillary degeneration, anti ...
Streit, Wolfgang J., Xue, Qing-Shan, Ingo Bechmann, Bechmann, Ingo, Braak, Heiko, Wolfgang J. Streit, Heiko Braak, Qing-Shan Xue   +7 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Chemogenetic Modulation of Astrocytic Activity Rescues Hippocampus Associated Neurodegeneration in Alzheimer’s Disease Mice Model 5xFAD

Neural Plasticity
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by Aβ-amyloid accumulation and cognitive decline. Despite extensive research, effective treatments remain elusive.
Evgenii Gerasimov, Maria Berg, Anastasia Bolshakova, Ilya Bezprozvanny, Olga Vlasova   +4 more
doaj   +1 more source

Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission

Frontiers in Pharmacology, 2021
Glia-mediated inflammatory processes are crucial in the pathogenesis of Parkinson’s disease (PD). As the most abundant cells of the brain and active participants in neuroinflammatory responses, astrocytes largely propagate inflammatory signals and ...
Nanshan Song, Hong Zhu, Rong Xu, Jiaqi Liu, Yinquan Fang, Jing Zhang, Jianhua Ding, Gang Hu, Gang Hu, Ming Lu, Ming Lu   +10 more
doaj   +1 more source