Results 41 to 50 of about 307,834 (316)
Autophagy, aging, and age-related neurodegeneration.
NeuronAutophagy is a conserved mechanism that degrades damaged or superfluous cellular contents and enables nutrient recycling under starvation conditions.
Jennifer E. Palmer +8 more
semanticscholar +1 more source
STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance It is increasingly recognized that chronic neuroinflammation is causally relevant to neurodegeneration. In Parkinson’s disease (PD), α-synuclein pathology activates inflammatory signaling that disturbs parenchymal homeostasis and disrupts ...
J. Hinkle +11 more
semanticscholar +1 more source
Neurobiology of Disease, 2020 Parkinson's disease (PD) is defined by motor symptoms such as tremor at rest, bradykinesia, postural instability, and stiffness. In addition to the classical motor defects that define PD, up to 80% of patients experience cognitive changes and psychiatric
Lindsay E. Stoyka +9 more
doaj +1 more source
14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model
Acta Neuropathologica Communications, 2021 Alpha-synuclein (αsyn) is the key component of proteinaceous aggregates termed Lewy Bodies that pathologically define a group of disorders known as synucleinopathies, including Parkinson’s Disease (PD) and Dementia with Lewy Bodies.
Rachel Underwood +6 more
doaj +1 more source
Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration.
Neuropharmacology, 2021 Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of glutamate is of paramount importance for normal brain function and relies on an intricate metabolic collaboration between neurons and astrocytes.
J. V. Andersen +6 more
semanticscholar +1 more source
Iron imbalance in neurodegeneration
Molecular PsychiatryIron is an essential element for the development and functionality of the brain, and anomalies in its distribution and concentration in brain tissue have been found to be associated with the most frequent neurodegenerative diseases.
Sonia Levi +3 more
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A manifesto for Alzheimer’s disease drug discovery in the era of disease-modifying therapies
Molecular NeurodegenerationAfter decades of disappointment, three disease-modifying therapies for Alzheimer’s disease (AD) have been approved since 2021. Burgeoning clinical data on these amyloid β-protein (Aβ) targeting drugs validate the amyloid cascade hypothesis as a molecular
Heike Hering +6 more
doaj +1 more source
Cell StressStress granules (SGs) are highly dynamic micromolecular membraneless condensates that generate in cells subjected to stress. Formed from pools of untranslating messenger ribonucleoproteins (RNP), SGs dynamics constitute vital processes essential for cell
Hebatallah Abdelrasol +5 more
doaj +1 more source
Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain
Molecular Neurodegeneration, 2022 Background Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson’s disease (PD). Aggregated α-synuclein pathologically defines PD.
Enquan Xu +15 more
doaj +1 more source