Results 31 to 40 of about 93,036 (258)
Impaired DNA damage response signaling by FUSNLS mutations leads to neurodegeneration and FUS aggregate formation [PDF]
, 2018 Amyotrophic lateral sclerosis (ALS) is the most frequent motor neuron disease. Cytoplasmic fused in sarcoma (FUS) aggregates are pathological hallmarks of FUS-ALS.
Jochen H. Weishaupt +62 more
core +1 more source
Sphingolipids in Neurodegeneration [PDF]
NeuroMolecular Medicine, 2010 Although the brain contains a high content of sphingolipids, we know relatively little about the roles that sphingolipids play in regulating neural functions. Once regarded only for their structural roles in maintaining the integrity of cellular and sub-cellular compartments, it is now apparent that many sphingolipid species are biologically active and
openaire +2 more sources
Evolution of Neurodegeneration [PDF]
Current Biology, 2012 A number of neurodegenerative diseases principally affect humans as they age and are characterized by the loss of specific groups of neurons in different brain regions. Although these disorders are generally sporadic, it is now clear that many of them have a substantial genetic component.
openaire +2 more sources
Brain Sciences, 2023 Observational studies have shown abnormal changes in trimethylamine N-oxide (TMAO) levels in the peripheral circulatory system of Parkinson’s disease (PD) patients.
Wei Quan +7 more
doaj +1 more source
Molecular Brain, 2021 Rho-associated kinase isoform 2 (ROCK2) is an attractive drug target for several neurologic disorders. A critical barrier to ROCK2-based research and therapeutics is the lack of a mouse model that enables investigation of ROCK2 with spatial and temporal ...
Audrey J. Weber +8 more
doaj +1 more source
Neurobiology of Disease, 2020 Parkinson's disease (PD) is defined by motor symptoms such as tremor at rest, bradykinesia, postural instability, and stiffness. In addition to the classical motor defects that define PD, up to 80% of patients experience cognitive changes and psychiatric
Lindsay E. Stoyka +9 more
doaj +1 more source
14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model
Acta Neuropathologica Communications, 2021 Alpha-synuclein (αsyn) is the key component of proteinaceous aggregates termed Lewy Bodies that pathologically define a group of disorders known as synucleinopathies, including Parkinson’s Disease (PD) and Dementia with Lewy Bodies.
Rachel Underwood +6 more
doaj +1 more source
Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain
Molecular Neurodegeneration, 2022 Background Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson’s disease (PD). Aggregated α-synuclein pathologically defines PD.
Enquan Xu +15 more
doaj +1 more source
Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease [PDF]
, 2018 Parkinson's disease (PD) is the second most common neurodegenerative disorder, leading to the progressive decline of motor control due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc).
López, Nélida +16 more
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Advantages and limitations of hiPSC-derived neurons for the study of neurodegeneration
, 2022 Neurodegenerative diseases, such as Alzheimer's disease (AD), are expensive, common, and will likely increase as the population ages. The lack of significant therapeutic development indicates that further research is needed on various cellular mechanisms
van Deursen, Coen +6 more
core +1 more source