Results 31 to 40 of about 307,834 (316)
Ecstasy and neurodegeneration [PDF]
BMJ, 1996 Publicity in the popular press and medical journals1 on the dangers of using ecstasy (3,4-methylenedioxymethamphetamine) has concentrated almost exclusively on the problems of acute toxicity. While the unnecessary death of any young person is rightly deplored, it is strange that so little attention is being paid to the long term effects of this ...
A R, Green, G M, Goodwin
openaire +2 more sources
Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy
Frontiers in Neuroscience, 2021 Microglia are the resident macrophages of the central nervous system (CNS) acting as the first line of defense in the brain by phagocytosing harmful pathogens and cellular debris. Microglia emerge from early erythromyeloid progenitors of the yolk sac and
L. Muzio, Alice Viotti, G. Martino
semanticscholar +1 more source
The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease.
Brain : a journal of neurology, 2023 Over the last several years, there has been a surge in blood biomarker studies examining the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration for Alzheimer's disease (AD).
Youjin Jung, J. Damoiseaux
semanticscholar +1 more source
Acta Neuropathologica Communications, 2022 Genetic and neuropathological evidence strongly implicates aberrant forms of α-synuclein in neurodegeneration. Antibodies specific for α-synuclein phosphorylated at serine 129 (pS129) are selective for the pathological protein aggregates that are ...
Rose B. Creed +4 more
doaj +1 more source
Mechanisms Underlying Inflammation in Neurodegeneration
Cell, 2010 Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis.
C. Glass +4 more
semanticscholar +1 more source
Molecular Medicine, 2023 Background Soluble oligomeric forms of alpha-synuclein (aSyn-O) are believed to be one of the main toxic species in Parkinson’s disease (PD) leading to degeneration.
Ricardo Sant’Anna +6 more
doaj +1 more source
Brain Sciences, 2023 Observational studies have shown abnormal changes in trimethylamine N-oxide (TMAO) levels in the peripheral circulatory system of Parkinson’s disease (PD) patients.
Wei Quan +7 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2022 Traumatic brain injury (TBI) is one of the most common diseases in the central nervous system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many sequelae in the life time post injury, including neurodegenerative disorders such
Fangjie Shao +4 more
semanticscholar +1 more source
Journal of Neuroinflammation, 2022 Background The development of morphine tolerance is a clinical challenge for managing severe pain. Studies have shown that neuroinflammation is a critical aspect for the development of analgesic tolerance.
Li Wan +9 more
doaj +1 more source
Molecular Brain, 2021 Rho-associated kinase isoform 2 (ROCK2) is an attractive drug target for several neurologic disorders. A critical barrier to ROCK2-based research and therapeutics is the lack of a mouse model that enables investigation of ROCK2 with spatial and temporal ...
Audrey J. Weber +8 more
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