Results 51 to 60 of about 271,126 (314)

Regulatory T cells limit age-associated retinal inflammation and neurodegeneration [PDF]

Ageing; Neurodegeneration; RetinaEnvejecimiento; Neurodegeneración; RetinaEnvelliment; Neurodegeneració; RetinaBackground Ageing is the principal risk factor for retinal degenerative diseases, which are the commonest cause of blindness in the developed ...
Dooley, James, McMurran, Christopher, Liston, Adrian, de la Fuente, Alerie Guzman, Llorián-Salvador, María, Dashwood, Amy   +5 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dysregulated miR-124 mediates impaired social memory behavior caused by paternal early social isolation

Translational Psychiatry
Early social isolation (SI) leads to various abnormalities in emotion and behavior during adulthood. However, the negative impact of SI on offspring remains unclear.
Sijia Chen, Shixin Ding, Yingting Pang, Yuxi Jin, Peng Sun, Yue Li, Min Cao, Yimiao Wang, Ze Wang, Tianqi Wang, Ying Zou, Yanli Zhang, Ming Xiao   +12 more
doaj   +1 more source

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

Neurobiology of Disease, 2017
Proteinaceous inclusions in neurons, composed primarily of α-synuclein, define the pathology in several neurodegenerative disorders. Neurons can internalize α-synuclein fibrils that can seed new inclusions from endogenously expressed α-synuclein.
Hisham Abdelmotilib, Tyler Maltbie, Vedad Delic, Zhiyong Liu, Xianzhen Hu, Kyle B. Fraser, Mark S. Moehle, Lindsay Stoyka, Nadia Anabtawi, Valentina Krendelchtchikova, Laura A. Volpicelli-Daley, Andrew West   +11 more
doaj   +1 more source

Striatal neuroinflammation promotes parkinsonism in rats

, 2008
The specific role of neuroinflammation in the pathogenesis of Parkinson's disease remains to be fully elucidated. By infusing lipopolysaccharide (LPS) into the striatum, we investigated the effect of neuroinflammation on the dopamine nigrostriatal ...
Randy L Hunter, Wayne Cass, Patrick G Sullivan, Pandya, Jignesh D., Dong-Young Choi, Don Gash, Patrick Sullivan, Hyoung-Chun Kim, Cass, Wayne A., Jignesh D Pandya, Hunter, Randy L., Don M Gash, Bing, Guoying, Randy Hunter, Eun-Joo Shin, Jignesh Pandya, Wayne A Cass, Gash, Don M., Sullivan, Patrick G., Choi, Dong-Young, Shin, Eun-Joo, Liu, Mei, Kim, Hyoung-Chun, Mei Liu, Guoying Bing   +24 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Arhgef7 as a key target for enriched environment rescuing spatial cognitive deficits and anxiety-like behaviors in a mouse model of Alzheimer’s disease following early social isolation

Alzheimer’s Research & Therapy
Background Both social and physical environmental factors influence the progression of Alzheimer’s disease (AD), but the underlying mechanisms are not yet fully understood.
Yimiao Wang, Ze Wang, Yue Li, Min Cao, Shuying Zhang, Shixin Ding, Sijia Chen, Yuxi Jin, Yanli Zhang, Junying Gao, Ming Xiao   +10 more
doaj   +1 more source

Engaging People With Lived Experience of Dementia in Research: Perspectives From a Multi-disciplinary Research Network

Canadian Geriatrics Journal, 2022
Background Patient and public involvement/engagement in research on dementia is not new, but it is becoming increasingly common. The objective of this study was to describe researchers’ knowledge, attitudes, and activities related to engaging people ...
Lauren E. Bechard, Katherine S. McGilton, Laura E. Middleton, Howard Chertkow, Saskia Sivananthan, Jennifer Bethell   +5 more
doaj   +1 more source

Advantages and limitations of hiPSC-derived neurons for the study of neurodegeneration

, 2022
Neurodegenerative diseases, such as Alzheimer's disease (AD), are expensive, common, and will likely increase as the population ages. The lack of significant therapeutic development indicates that further research is needed on various cellular mechanisms
van Deursen, Coen, Van Der Kant, Rik, Buttermore, Elizabeth D., Mishra, Swati, Van Deursen, Coen; id_orcid, Young, Jessica E., Robert, Aiko   +6 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source