Results 51 to 60 of about 307,834 (316)

Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders

Nature Reviews Neuroscience, 2011
The neurovascular unit (NVU) comprises brain endothelial cells, pericytes or vascular smooth muscle cells, glia and neurons. The NVU controls blood–brain barrier (BBB) permeability and cerebral blood flow, and maintains the chemical composition of the ...
B. Zlokovic
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Tau and neurodegeneration

Cytoskeleton, 2023
AbstractFirst identified in 1975, tau was implicated in Alzheimer's disease 10 years later. Filamentous tangle inclusions were known to be made of hyperphosphorylated tau by 1991, with similar inclusions gaining recognition for being associated with other neurodegenerative diseases. In 1998, mutations in MAPT, the gene that encodes tau, were identified
Goedert, Michel, Crowther, R Anthony, Scheres, Sjors HW, Spillantini, Maria Grazia   +3 more
openaire   +2 more sources

Mossy cell hypertrophy and synaptic changes in the hilus following mild diffuse traumatic brain injury in pigs

Journal of Neuroinflammation, 2020
Background Each year in the USA, over 2.4 million people experience mild traumatic brain injury (TBI), which can induce long-term neurological deficits.
Michael R. Grovola, Nicholas Paleologos, Kathryn L. Wofford, James P. Harris, Kevin D. Browne, Victoria Johnson, John E. Duda, John A. Wolf, D. Kacy Cullen   +8 more
doaj   +1 more source

APOE mediated neuroinflammation and neurodegeneration in Alzheimer’s Disease

Seminars in Immunology, 2022
Neuroinflammation is a central mechanism involved in neurodegeneration as observed in Alzheimer’s disease (AD), the most prevalent form of neurodegenerative disease. Apolipoprotein E4 (APOE4), the strongest genetic risk factor for AD, directly influences
S. Parhizkar, D. Holtzman
semanticscholar   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Chemogenetic Modulation of Astrocytic Activity Rescues Hippocampus Associated Neurodegeneration in Alzheimer’s Disease Mice Model 5xFAD

Neural Plasticity
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by Aβ-amyloid accumulation and cognitive decline. Despite extensive research, effective treatments remain elusive.
Evgenii Gerasimov, Maria Berg, Anastasia Bolshakova, Ilya Bezprozvanny, Olga Vlasova   +4 more
doaj   +1 more source

Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission

Frontiers in Pharmacology, 2021
Glia-mediated inflammatory processes are crucial in the pathogenesis of Parkinson’s disease (PD). As the most abundant cells of the brain and active participants in neuroinflammatory responses, astrocytes largely propagate inflammatory signals and ...
Nanshan Song, Hong Zhu, Rong Xu, Jiaqi Liu, Yinquan Fang, Jing Zhang, Jianhua Ding, Gang Hu, Gang Hu, Ming Lu, Ming Lu   +10 more
doaj   +1 more source

Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities

Cell Death and Differentiation, 2021
Neurodegenerative diseases are characterised by progressive damage to the nervous system including the selective loss of vulnerable populations of neurons leading to motor symptoms and cognitive decline.
Marlene Schmidt, Z. Gan, D. Komander, G. Dewson   +3 more
semanticscholar   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source