Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation [PDF]
Neurobiology of Disease, 2020 In Parkinson's disease, some of the first alpha-synuclein aggregates appear in the olfactory system and the dorsal motor nucleus of the vagus nerve before spreading to connected brain regions.
Christopher Mezias +3 more
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Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
Neurobiology of Disease, 2011 Alpha-synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha-synuclein from pathologically affected to healthy unaffected neurons may be important in the anatomical spread of the disease through the ...
Lydia Alvarez-Erviti +6 more
doaj +3 more sources
Microtubule depolymerization potentiates alpha-synuclein oligomerization [PDF]
Frontiers in Aging Neuroscience, 2010 Parkinson’s disease (PD) is associated with perturbed mitochondria function and alpha-synuclein fibrillization. We evaluated potential mechanistic links between mitochondrial dysfunction and alpha-synuclein aggregation.
Russell H Swerdlow, Catarina Oliveira
doaj +3 more sources
Alpha synuclein and inflammaging
HeliyonThe α-synuclein protein is an established molecule in Lewy body pathology, especially Parkinson's disease (PD). While the pathological role of α-synuclein (α-syn) in PD has been well described, novel evidence may suggest that α-syn interacts with ...
Geneviève L. Putnam, Robert W. Maitta
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A split biotin ligase approach reveals proteins associated with oligomeric alpha-synuclein during aggregation [PDF]
Scientific ReportsLewy pathology can form over decades in patients with Lewy body diseases, but the causal cellular mechanisms associated with this process remain unclear.
Analiese R. Fernandes +13 more
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Alpha synuclein in hematopoiesis and immunity
Heliyon, 2019 Parkinson's disease (PD) is the second most common neurodegenerative condition and intracellular deposition of Lewy bodies in the substantia nigra (SN), which can cause dopaminergic neuronal death, is the hallmark of this syndrome. α-synuclein (syn) is a
Yu Pei, Robert W. Maitta
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Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures. [PDF]
PLoS ONE, 2015 Overexposure to manganese has been known to promote alpha-synuclein oligomerization and enhance cellular toxicity. However, the exact mechanism of Mn-induced alpha-synuclein oligomerization is unclear.
Bin Xu +5 more
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TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson's Disease. [PDF]
, 2013 Alpha-synuclein (α-Syn) accumulation/aggregation and mitochondrial dysfunction play prominent roles in the pathology of Parkinson's disease. We have previously shown that postmortem human dopaminergic neurons from PD brains accumulate high levels of ...
A Bender +60 more
core +10 more sources
Alpha-synuclein suppression by targeted small interfering RNA in the primate substantia nigra. [PDF]
PLoS ONE, 2010 The protein alpha-synuclein is involved in the pathogenesis of Parkinson's disease and other neurodegenerative disorders. Its toxic potential appears to be enhanced by increased protein expression, providing a compelling rationale for therapeutic ...
Alison L McCormack +5 more
doaj +1 more source
Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
Scientific Reports, 2022 AbstractParkinson′s disease (PD) pathology progresses throughout the nervous system affecting numerous neuronal structures. It has been postulated that the progression of the pathology is based on a prion-like disease mechanism partly due to the seeding effect of endocytosed alpha-synuclein (ASYN) on the endogenous ASYN. The appearance of the pathology
Yanina Dening +16 more
openaire +6 more sources