Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
Neurobiology of Disease, 2011 Alpha-synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha-synuclein from pathologically affected to healthy unaffected neurons may be important in the anatomical spread of the disease through the ...
Yiqi Seow +2 more
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Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures. [PDF]
PLoS ONE, 2015 Overexposure to manganese has been known to promote alpha-synuclein oligomerization and enhance cellular toxicity. However, the exact mechanism of Mn-induced alpha-synuclein oligomerization is unclear.
Bin Xu +5 more
doaj +1 more source
Alpha-synuclein suppression by targeted small interfering RNA in the primate substantia nigra. [PDF]
PLoS ONE, 2010 The protein alpha-synuclein is involved in the pathogenesis of Parkinson's disease and other neurodegenerative disorders. Its toxic potential appears to be enhanced by increased protein expression, providing a compelling rationale for therapeutic ...
Alison L McCormack +5 more
doaj +1 more source
Preanalytical Stability of CSF Total and Oligomeric Alpha-Synuclein
Frontiers in Aging Neuroscience, 2021 Background: The role of cerebrospinal fluid (CSF) alpha-synuclein as a potential biomarker has been challenged mainly due to variable preanalytical measures between laboratories.
Ilham Y. Abdi +7 more
doaj +1 more source
The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy. [PDF]
PLoS ONE, 2010 BACKGROUND: Aggregation and misfolded alpha-synuclein is thought to be central in the pathogenesis of Parkinson's disease (PD). Heat-shock proteins (HSPs) that are involved in refolding and degradation processes could lower the aggregate load of alpha ...
Derya R Shimshek +4 more
doaj +1 more source
Molecules, 2021 The accumulation of the various products of alpha-synuclein aggregation has been associated with the etiology and pathogenesis of several neurodegenerative conditions, including both familial and sporadic forms of Parkinson’s disease (PD) and dementia ...
Mae Upcott +2 more
doaj +1 more source
Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats. [PDF]
PLoS ONE, 2010 BACKGROUND: The pathology of Parkinson's disease (PD) is characterized by the degeneration of the nigrostriatal dopaminergic pathway, as well as the formation of intraneuronal inclusions known as Lewy bodies and Lewy neurites in the substantia nigra ...
Zhongwang Yu +6 more
doaj +1 more source
Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]
PLoS ONE, 2009 In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Margot Fournier +22 more
doaj +1 more source
Neurobiology of Disease, 2023 Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition. Dopaminergic cell loss is associated with accumulation of toxic alpha synuclein aggregates.
Robert Brendza +19 more
doaj +1 more source
Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease
Frontiers in Molecular Neuroscience, 2019 Parkinson’s disease (PD) is one of the most common neurodegenerative disorders with a global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both the sporadic and familial forms of the disease.
Carroll Rutherford Fields +2 more
doaj +1 more source