Results 21 to 30 of about 33,680 (119)
Parkinson's disease-related protein, alpha-synuclein, in malignant melanoma. [PDF]
PLoS ONE, 2010 Melanoma is the major cause of skin cancer death worldwide. Parkinson's disease is a neurodegenerative disorder that is caused by mutation of alpha-synuclein or other genes. Importantly, epidemiological studies have reported co-occurrence of melanoma and
Yasuhiro Matsuo, Tetsu Kamitani
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Synaptic Changes in Mice Lacking Alpha- and Gamma-Synucleins
BiomedicinesBackground: Alpha-synuclein is a key protein involved in the pathogenesis of Parkinson disease (PD). Its intermediate aggregated forms disturb the normal function of dopaminergic (DA) neurons.
Anastasia M. Krayushkina +5 more
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Parkinson's disease (PD) is the most common neurodegenerative disease
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2015 Metabolic impairment of alpha-synuclein protein is considered to be the central event in PDpathogenesis. Recent studies explored usage of alpha-synuclein in peripheral fluids as a biomarker of PD, however alpha-synuclein level in the CSF and plasma is ...
P. A. Andoskin +7 more
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Associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults
Annals of Clinical and Translational Neurology, 2020 Objective Sleep disorders as a preclinical symptom of synucleinopathies become more prevalent in older adults. Synucleinopathies might be caused by the abnormal aggregation of alpha‐synuclein in the brain, which was indicated by alpha‐synuclein levels in
Xiao‐Tong Wang +7 more
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Neurobiology of Disease, 2023 The role of alpha-synuclein in Parkinson's disease has been heavily investigated since its discovery as a component of Lewy bodies. Recent rodent data demonstrate that alpha-synuclein strain structure is critical for differential propagation and toxicity.
Audrey Fayard +15 more
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PLoS ONE, 2011 The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alpha-synuclein belongs to the homologous synuclein family, which includes beta-synuclein.
Patrick C McHugh +2 more
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Bioengineering & Translational MedicineSynucleinopathies, including Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are neurodegenerative disorders caused by the accumulation of misfolded alpha‐synuclein protein.
Jose Miguel Flores‐Fernandez +13 more
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Association between Serum Alpha-Synuclein Levels and Parkinson's Disease Stage
Global Medical & Health Communication, 2022 Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's. It is chronically progressive with the main symptoms of resting tremor, rigidity, bradykinesia, and postural disturbances.
Yuliarni Syafrita, Restu Susanti
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Evaluation of Stp2p-dependent alpha-Synuclein Toxicity in Yeast: Role of GAPDH? [PDF]
Impulse: The Premier Undergraduate Neuroscience Journal, 2006 Parkinson's disease (PD) is linked to alpha-synuclein misfolding and aggregation in the substantia nigra par compacta cells of the brain. Discovering and characterizing factors that regulate alpha-synuclein misfolding and toxicity have high therapeutic ...
Arun George Paul
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Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes. [PDF]
PLoS ONE, 2016 Parkinson's disease and other alpha-synucleinopathies are progressive neurodegenerative diseases characterized by aggregates of misfolded alpha-synuclein spreading throughout the brain. Recent evidence suggests that the pathological progression is likely
Jakob Domert +6 more
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