Results 21 to 30 of about 659,948 (302)

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells [PDF]

Neuroscience Letters, 2008
Alpha-synuclein (alpha-syn) is implicated in the pathogenesis of Parkinson's disease (PD). Mutations in alpha-syn gene or alpha-syn locus (SNCA) triplication are associated with mitochondrial abnormalities and early onset of familial PD. The goals of the present study were to examine whether alpha-syn is localized in the mitochondria of alpha-syn ...
Shaik, Shavali, Holly M, Brown-Borg, Manuchair, Ebadi, James, Porter   +3 more
openaire   +2 more sources

Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease

Neurobiology of Disease, 2023
Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition. Dopaminergic cell loss is associated with accumulation of toxic alpha synuclein aggregates.
Robert Brendza, Xiaoying Gao, Kimberly L. Stark, Han Lin, Seung-Hye Lee, Changyun Hu, Hao Cai, Danielle DiCara, Yi-Chun Hsiao, Hai Ngu, Oded Foreman, Miriam Baca, Monika Dohse, Jean-Phillipe Fortin, Racquel Corpuz, Dhaya Seshasayee, Amy Easton, Gai Ayalon, Isidro Hötzel, Ben Chih   +19 more
doaj   +1 more source

Gastrointestinal Immunity and Alpha-Synuclein [PDF]

Journal of Parkinson’s Disease, 2019
The gastrointestinal (GI) tract is equipped with robust immune defenses which protect the organism from infection. Enteric nerves are front and center in this defensive network, even in the most primitive organisms. Neuropeptides exhibit potent antimicrobial activity in the vicinity of the nerve and attract the innate and adaptive immune systems to ...
Barbut, Denise, Stolzenberg, Ethan, Zasloff, Michael   +2 more
openaire   +2 more sources

C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging [PDF]

, 2008
Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood.
Plasterk, Ronald H. A., Breitling, Rainer, Breitling, R., Breitling, Rainer,, Hofstra, R.M.W., Van Ham, Tjakko J., Thijssen, Karen L.,, Karen L Thijssen, van Ham, T.J., Plasterk, Ronald H A, Ronald H A Plasterk, Thijssen, K.L., Nollen, Ellen A A, Plasterk, R.H.A., Nollen, Ellen A.A.,, Hofstra, Robert M W, Ellen A A Nollen, Tjakko J van Ham, Rainer Breitling, Robert M W Hofstra, Nollen, Ellen A. A., Ham, Tjakko J. van,, Nollen, E.A.A., Plasterk, Ronald H.A.,, Hofstra, Robert M.W.,, Nollen, Ellen A. A.; id_orcid, Hofstra, Robert M. W., Thijssen, Karen L.   +27 more
core   +1 more source

The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity [PDF]

, 2012
Overexpression or mutation of alpha-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function.
Butler, Erin K., Jane P Toegel, Jane P. Toegel (185544), Winklhofer Konstanze F., A Kathrin Lutz, Voigt Aaron, Falkenburger, Bjoern, Toegel Jane P., Konstanze F. Winklhofer (185550), Gerhardt, Ellen, Karsten Peter, A. Kathrin Lutz (185542), Voigt, Aaron, Butler Erin K., Toegel, Jane P., Peter Karsten (123433), Björn Falkenburger (185548), Schulz, Joerg B., Falkenburger, Bjoern H., Peter Karsten, Ellen Gerhardt (185546), Andrea Reinartz (185549), Reinartz, Andrea, Erin K Butler, Ellen Gerhardt, Lutz A. Kathrin, Jörg B Schulz, Gerhardt Ellen, Aaron Voigt (123446), Reinartz Andrea, Jörg B. Schulz (123442), Lutz, A. Kathrin, Karsten, Peter, Konstanze F Winklhofer, Aaron Voigt, Björn Falkenburger, Schulz Jörg B., Erin K. Butler (185540), Winklhofer, Konstanze F., Falkenburger Björn, Andrea Reinartz, Toegel, Jane Patricia   +41 more
core   +1 more source

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum [PDF]

Life, 2020
Endoplasmic reticulum (ER) dysfunction is important for alpha-synuclein (αS) acquired toxicity. When targeted to the ER in SH-SY5Y cells, transient or stable expression of αS resulted in the formation of compact αS-positive structures in a small subpopulation of cells, resembling αS inclusions. Thus, because of the limitations of immunofluorescence, we
Miraglia F., Valvano V., Rota L., Di Primio C., Quercioli V., Betti L., Giannaccini G., Cattaneo A., Colla E.   +8 more
openaire   +3 more sources

Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease

Frontiers in Molecular Neuroscience, 2019
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders with a global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both the sporadic and familial forms of the disease.
Carroll Rutherford Fields, Nora Bengoa-Vergniory, Richard Wade-Martins   +2 more
doaj   +1 more source

A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP [PDF]

, 2011
Parkinson’s disease (PD) is a neurodegenerative disorder frequent at old age characterized by atrophy of the nigrostriatal projection. Overexpression and A53T-mutation of the presynaptic, vesicle-associated chaperone alpha-synuclein are known to cause ...
Oliver Schmidt, Meyer, Helmut E., Gispert, Suzana, Kurz, Alexander, May, Caroline, Helmut E. Meyer, Suzana Gispert, Marcus, Katrin, Christian Stephan, Georg Auburger, Müller, Thorsten, Auburger, Georg, Caroline May, Katrin Marcus, Alexander Kurz, Schmidt, Oliver, Thorsten Müller, Stephan, Christian   +17 more
core   +1 more source

Targeted Extracellular Vesicle Gene Therapy for Modulating Alpha-Synuclein Expression in Gut and Spinal Cord

Pharmaceutics, 2023
The development of effective disease-modifying therapies to halt Parkinson’s disease (PD) progression is required. In a subtype of PD patients, alpha-synuclein pathology may start in the enteric nervous system (ENS) or autonomic peripheral nervous system.
Maria Izco, Martin Schleef, Marco Schmeer, Estefania Carlos, Guglielmo Verona, Lydia Alvarez-Erviti   +5 more
doaj   +1 more source

Neuropathology in mice expressing mouse alpha-synuclein [PDF]

, 2011
?-Synuclein (?SN) in human is tightly linked both neuropathologically and genetically to Parkinson's disease (PD) and related disorders. Disease-causing properties in vivo of the wildtype mouse ortholog (m?SN), which carries a threonine at position 53 ...
Kahle, Philipp J., Ksiazek, Iwona, Derya R Shimshek, Markus A Ruegg, Rieker Claus, Cindy Boden, Ruegg Markus A., Derya R. Shimshek, Dev, Kumlesh K., Simone Danner, Heinrich Schell, Herman van der Putten, Claus Rieker, Ruegg, Markus A., Philipp J Kahle, Iwona Ksiazek, Boden Cindy, Kumlesh K Dev, Sabine Kauffmann, Schell, Heinrich, van der Putten Herman, Kauffmann Sabine, Dev Kumlesh K., Kumlesh K. Dev, Shimshek, Derya R., Lehnhoff Katja, Ksiazek Iwona, Katja Lehnhoff, Shimshek Derya R., Schell Heinrich, Rieker, Claus, Samuel Barbieri, Philipp J. Kahle, van der Putten, Herman, Kauffmann, Sabine, Lehnhoff, Katja, Markus A. Ruegg, Kahle Philipp J., Danner, Simone, Barbieri, Samuel, Danner Simone, Boden, Cindy, Barbieri Samuel   +42 more
core   +1 more source