Results 21 to 30 of about 61,554 (301)
Formation of toxic oligomeric alpha-synuclein species in living cells. [PDF]
PLoS ONE, 2008 Misfolding, oligomerization, and fibrillization of alpha-synuclein are thought to be central events in the onset and progression of Parkinson's disease (PD) and related disorders.
Tiago Fleming Outeiro +7 more
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Preanalytical Stability of CSF Total and Oligomeric Alpha-Synuclein
Frontiers in Aging Neuroscience, 2021 Background: The role of cerebrospinal fluid (CSF) alpha-synuclein as a potential biomarker has been challenged mainly due to variable preanalytical measures between laboratories.
Ilham Y. Abdi +7 more
doaj +1 more source
The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy. [PDF]
PLoS ONE, 2010 BACKGROUND: Aggregation and misfolded alpha-synuclein is thought to be central in the pathogenesis of Parkinson's disease (PD). Heat-shock proteins (HSPs) that are involved in refolding and degradation processes could lower the aggregate load of alpha ...
Derya R Shimshek +4 more
doaj +1 more source
Molecules, 2021 The accumulation of the various products of alpha-synuclein aggregation has been associated with the etiology and pathogenesis of several neurodegenerative conditions, including both familial and sporadic forms of Parkinson’s disease (PD) and dementia ...
Mae Upcott +2 more
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Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells [PDF]
Neuroscience Letters, 2008 Alpha-synuclein (alpha-syn) is implicated in the pathogenesis of Parkinson's disease (PD). Mutations in alpha-syn gene or alpha-syn locus (SNCA) triplication are associated with mitochondrial abnormalities and early onset of familial PD. The goals of the present study were to examine whether alpha-syn is localized in the mitochondria of alpha-syn ...
Shaik, Shavali +3 more
openaire +2 more sources
Synapsin Condensates Recruit alpha-Synuclein
Journal of Molecular Biology, 2021 Neurotransmission relies on the tight spatial and temporal regulation of the synaptic vesicle (SV) cycle. Nerve terminals contain hundreds of SVs that form tight clusters. These clusters represent a distinct liquid phase in which one component of the phase are SVs and the other synapsin 1, a highly abundant synaptic protein.
Hoffmann, Christian +7 more
openaire +4 more sources
Alpha-synuclein modulates dopamine neurotransmission [PDF]
Journal of Chemical Neuroanatomy, 2017 Alpha-synuclein is a small, highly charged protein encoded by the synuclein or SNCA gene that is predominantly expressed in central nervous system neurons. Although its physiological function remains enigmatic, alpha-synuclein is implicated in movement disorders such as Parkinson's disease, multiple system atrophy, and in neurodegenerative diseases ...
Brittany Butler +2 more
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Gastrointestinal Immunity and Alpha-Synuclein [PDF]
Journal of Parkinson’s Disease, 2019 The gastrointestinal (GI) tract is equipped with robust immune defenses which protect the organism from infection. Enteric nerves are front and center in this defensive network, even in the most primitive organisms. Neuropeptides exhibit potent antimicrobial activity in the vicinity of the nerve and attract the innate and adaptive immune systems to ...
Barbut, Denise +2 more
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Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum [PDF]
Life, 2020 Endoplasmic reticulum (ER) dysfunction is important for alpha-synuclein (αS) acquired toxicity. When targeted to the ER in SH-SY5Y cells, transient or stable expression of αS resulted in the formation of compact αS-positive structures in a small subpopulation of cells, resembling αS inclusions. Thus, because of the limitations of immunofluorescence, we
Fabiana Miraglia +8 more
openaire +3 more sources
Molecular Neurodegeneration, 2010 Background Parkinson's disease (PD) involves the selective damage of dopaminergic neuron cells resulting from the accumulation and fibril formation of alpha-synuclein.
Kobayashi Natsuki +4 more
doaj +1 more source