Results 41 to 50 of about 33,680 (119)

Alpha Synuclein Toxicity and Non-Motor Parkinson’s

Cells
Parkinson’s disease (PD) is a common multisystem neurodegenerative disorder affecting 1% of the population over the age of 60 years. The main neuropathological features of PD are the loss of dopaminergic neurons in the substantia nigra pars compacta ...
Gabriella M. Mazzotta, Carmela Conte
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Dopamine-induced conformational changes in alpha-synuclein.

PLoS ONE, 2009
BackgroundOligomerization and aggregation of alpha-synuclein molecules play a major role in neuronal dysfunction and loss in Parkinson's disease [1]. However, alpha-synuclein oligomerization and aggregation have mostly been detected indirectly in cells ...
Tiago F Outeiro, Jochen Klucken, Kathryn Bercury, Julie Tetzlaff, Preeti Putcha, Luis M A Oliveira, Alexandre Quintas, Pamela J McLean, Bradley T Hyman   +8 more
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Alpha-Synuclein Toxicity in the Early Secretory Pathway: How it Drives Neurodegeneration in Parkinsons Disease

Frontiers in Neuroscience, 2015
Alpha-synuclein is a predominant player in the pathogenesis of Parkinson’s Disease. However, despite extensive study for two decades, its physiological and pathological mechanisms remain poorly understood.
Ting eWang, Ting eWang, Jesse C Hay
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Alpha-synuclein inclusions reduced by PIKfyve inhibition in Parkinson disease cell models

Neurobiology of Disease
Objective: Parkinson's disease (PD) pathophysiology is associated with a progressive loss of dopaminergic neurons in the substantia nigra and accumulation of insoluble inclusions of misfolded alpha-synuclein.
Sara Lucas-Del-Pozo, Giuseppe Uras, Federico Fierli, Veronica Lentini, Sofia Koletsi, Carlos Lazaro-Hernandez, Kai-Yin Chau, Derralynn A. Hughes, Anthony H.V. Schapira   +8 more
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α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

Acta Neuropathologica Communications, 2019
Alpha-synuclein inclusions, the hallmarks of synucleinopathies, are suggested to spread along neuronal connections in a stereotypical pattern in the brains of patients.
Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin   +8 more
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Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson's Disease

Journal of Parkinson’s Disease, 2011
Although the overabundance of human alpha-synuclein in nigral dopaminergic neurons is considered to play a pathogenic role in Parkinson's disease (PD), it remains unclear how alpha-synuclein leads to neuronal degeneration and motor symptoms.
P.G. Coune, J.C. Bensadoun, P. Aebischer, B.L. Schneider   +3 more
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Quantitative measures of total and phosphorylated alpha-synuclein in skin tissue as potential biomarkers for synucleinopathies

Journal of Parkinson’s Disease
Background Alpha-synuclein can be detected in skin biopsies of individuals with synucleinopathies. However, quantitative data of total and phosphorylated Serine 129 (pS129) alpha-synuclein in skin biopsies are scarce.
Bram L van der Gaag, Janna van Wetering, Martino L Morella, Johannes JP Breve, Niels Reijner, Jenna Pfeifer, Amador Simando, JJ van Hilten, Henk W Berendse, Annemieke JM Rozemuller, Marianna Bugiani, Thomas Kustermann, Venissa Machado, Markus Britschgi, Wilma DJ van de Berg   +14 more
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Synaptic attenuation by human alpha-synuclein depends on two amino acids in its C-terminal tail

Neurobiology of Disease
Alpha-synuclein is a protein primarily expressed in the central and peripheral nervous systems that is firmly implicated in Parkinson's disease and other neurodegenerative diseases termed the synucleinopathies.
Jen Riba, Liron Samuel, Alexandra Stavsky, Elior Adaoui, Tomer Ashkenazy, Daniel Sevilla-Sanchez, Daniel Gitler   +6 more
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A split biotin ligase approach reveals proteins associated with oligomeric alpha-synuclein during aggregation

Scientific Reports
Lewy pathology can form over decades in patients with Lewy body diseases, but the causal cellular mechanisms associated with this process remain unclear.
Analiese R. Fernandes, Abigail P. Owen, Ayman H. Faroqi, Jannifer Lee, Gunveen S. Sachdeva, Dmytro Morderer, Cody Hoffmann, Benjamin Madden, Shuwen Zhang, Yingxue Ren, Suelen L. Boschen, Akhilesh Pandey, Wilfried Rossoll, Pamela J. McLean   +13 more
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Inhibitory effect of Scutellaria pinnatifida Extracts on the Alpha synuclein Cytotoxicity

Journal of Medicinal Plants, 2019
Many of neurodegenerative diseases (NDs) are associated with formation of the protein aggregates called amyloidal fibrils. Fibrillization of alpha-synuclein seems to be a key stage in the creation and progression of NDs and finding the compounds that ...
Mahdieh Sashourpour, Dina Morshedi, Saber Zahri, Farhang Ali akbari, Marzieh Fottovat, Tayebeh Rajabian   +5 more
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