Results 41 to 50 of about 659,948 (302)

TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson's Disease. [PDF]

, 2013
Alpha-synuclein (α-Syn) accumulation/aggregation and mitochondrial dysfunction play prominent roles in the pathology of Parkinson's disease. We have previously shown that postmortem human dopaminergic neurons from PD brains accumulate high levels of ...
Adame, Anthony, Mueller, Sarina, Bender Andreas, Sarina Mueller, Koob Andrew O., Elstner Matthias, Elstner, Matthias, Desplats, Paula, Mante, Michael, Eliezer Masliah, Desplats Paula, Mueller Sarina, Spencer, Brian, Matthias Elstner, Thomas Klopstock, Masliah, Eliezer, Koob, Andrew O., Andreas Bender, Bender, Andreas, Masliah Eliezer, Anthony Adame, Klopstock Thomas, Rockenstein, Edward, Laub Christoph, Rockenstein Edward, Pham Emily, Brian Spencer, Mante Michael, Michael Mante, Klopstock, Thomas, Christoph Laub, Spencer Brian, Adame Anthony, Andrew O Koob, Paula Desplats, Emily Pham, Laub, Christoph, Pham, Emily, Edward Rockenstein   +38 more
core   +1 more source

Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk

Frontiers in Cellular Neuroscience, 2021
Alpha-synuclein accumulation in dopaminergic neurons is one of the primary features of Parkinson’s disease (PD). Despite its toxic properties during PD, alpha-synuclein has some important physiological functions.
Alix Booms, Gerhard A. Coetzee
doaj   +1 more source

Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes. [PDF]

, 2012
Synucleinopathies such as Parkinson's disease, multiple system atrophy and dementia with Lewy bodies are characterized by deposition of aggregated α-synuclein.
Felix Schmidt, Armin Giese, Hans Kretzschmar, Levin, Johannes, Kamp, Frits, Kretzschmar, Hans, Bötzel, Kai, Kai Bötzel, Johannes Levin, Schmidt, Felix, Frits Kamp, Giese, Armin   +11 more
core   +1 more source

Dopamine-induced conformational changes in alpha-synuclein. [PDF]

PLoS ONE, 2009
Oligomerization and aggregation of alpha-synuclein molecules play a major role in neuronal dysfunction and loss in Parkinson's disease [1]. However, alpha-synuclein oligomerization and aggregation have mostly been detected indirectly in cells using ...
Tiago F Outeiro, Jochen Klucken, Kathryn Bercury, Julie Tetzlaff, Preeti Putcha, Luis M A Oliveira, Alexandre Quintas, Pamela J McLean, Bradley T Hyman   +8 more
doaj   +1 more source

In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells. [PDF]

, 2013
α-Synuclein is a small protein strongly implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders. We report here the use of in-cell NMR spectroscopy to observe directly the structure and dynamics of this protein ...
Christopher A. Waudby (238969), A. W. P. Fitzpatrick, Cabrita, LD, Carlo Camilloni, C. A. Waudby, Cabrita Lisa D., Camilloni Carlo, Christodoulou, J, Waudby Christopher A., Christodoulou, John, John Christodoulou, Camilloni, C., Christopher M Dobson, Lisa D. Cabrita, Waudby, CA, Dobson Christopher M., Michele Vendruscolo (68357), Temussi, P.A., Lisa D Cabrita, Fitzpatrick, AW, Christopher M. Dobson, Christopher M. Dobson (181572), Fitzpatrick, A.W.P., Dobson, C.M., Anthony W. P. Fitzpatrick, John Christodoulou (450398), Dobson, CM, C. Camilloni, Cabrita, L.D., Vendruscolo, M, Anthony W. P. Fitzpatrick (450396), M. Vendruscolo, Carlo Camilloni (450395), Anthony W P Fitzpatrick, Lisa D. Cabrita (450397), L. D. Cabrita, Christodoulou John, C. M. Dobson, Waudby, Christopher A., J. Christodoulou, Camilloni, C, Fitzpatrick Anthony W. P., Christopher A Waudby, Michele Vendruscolo, Christopher A. Waudby, Vendruscolo Michele, Vendruscolo, M.   +46 more
core   +1 more source

Intercellular transmission of alpha-synuclein [PDF]

Frontiers in Molecular Neuroscience
An emerging theme in Parkinson’s disease (PD) is the propagation of α-synuclein pathology as the disease progresses. Research involving the injection of preformed α-synuclein fibrils (PFFs) in animal models has recapitulated the pathological spread observed in PD patients.
Wu, Shenjie, Schekman, Randy
openaire   +4 more sources

Pros and cons of a prion-like pathogenesis in Parkinson's disease [PDF]

, 2011
Background: Parkinson's disease (PD) is a slowly progressive neurodegenerative disorder which affects widespread areas of the brainstem, basal ganglia and cerebral cortex.
Chapman Joab, Hilker, Ruediger, Brotchie, Jonathan M, Hilker, Rüdiger, Hilker Ruediger, Brotchie, Jonathan M., Joab Chapman, Ruediger Hilker, Chapman, Joab, Jonathan M Brotchie, Brotchie Jonathan M   +10 more
core   +1 more source

Synaptic Changes in Mice Lacking Alpha- and Gamma-Synucleins

Biomedicines
Background: Alpha-synuclein is a key protein involved in the pathogenesis of Parkinson disease (PD). Its intermediate aggregated forms disturb the normal function of dopaminergic (DA) neurons.
Anastasia M. Krayushkina, Olga Morozova, Anastasia Khizeva, Tamara A. Ivanova, Natalia Ninkina, Kirill Chaprov   +5 more
doaj   +1 more source

Parkinson's disease-related protein, alpha-synuclein, in malignant melanoma. [PDF]

PLoS ONE, 2010
Melanoma is the major cause of skin cancer death worldwide. Parkinson's disease is a neurodegenerative disorder that is caused by mutation of alpha-synuclein or other genes. Importantly, epidemiological studies have reported co-occurrence of melanoma and
Yasuhiro Matsuo, Tetsu Kamitani
doaj   +1 more source

Associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults

Annals of Clinical and Translational Neurology, 2020
Objective Sleep disorders as a preclinical symptom of synucleinopathies become more prevalent in older adults. Synucleinopathies might be caused by the abnormal aggregation of alpha‐synuclein in the brain, which was indicated by alpha‐synuclein levels in
Xiao‐Tong Wang, Feng‐Tao Liu, Yan‐Lin Bi, Xue‐Ning Shen, Wei Xu, Jian Wang, Lan Tan, Jin‐Tai Yu   +7 more
doaj   +1 more source