Results 51 to 60 of about 659,948 (302)

alpha-Synuclein Dimer cMD (w/o eq.)

, 2023
Five runs of 300 ns conventional MD simulations on alpha-synuclein dimer.
Loizos Savva (16379223)
core   +1 more source

Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates

Neurobiology of Disease, 2023
The role of alpha-synuclein in Parkinson's disease has been heavily investigated since its discovery as a component of Lewy bodies. Recent rodent data demonstrate that alpha-synuclein strain structure is critical for differential propagation and toxicity.
Audrey Fayard, Alexis Fenyi, Sonia Lavisse, Sandra Dovero, Luc Bousset, Tracy Bellande, Sophie Lecourtois, Christophe Jouy, Martine Guillermier, Caroline Jan, Pauline Gipchtein, Benjamin Dehay, Erwan Bezard, Ronald Melki, Philippe Hantraye, Romina Aron Badin   +15 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Parkinson's disease (PD) is the most common neurodegenerative disease

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2015
Metabolic impairment of alpha-synuclein protein is considered to be the central event in PDpathogenesis. Recent studies explored usage of alpha-synuclein in peripheral fluids as a biomarker of PD, however alpha-synuclein level in the CSF and plasma is ...
P. A. Andoskin, A. K. Emelyanov, M. A. Nikolaev, K. A. Senkevich, V. P. Shilin, A. F. Yakimovskiy, A. A. Timofeeva, S. N. Pchelina   +7 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Alpha-Synuclein and Its Role in Melanocytes

Cells, 2022
Pigmentation is an important process in skin physiology and skin diseases and presumably also plays a role in Parkinson’s disease (PD). In PD, alpha-Synuclein (aSyn) has been shown to be involved in the pigmentation of neurons. The presynaptic protein is intensively investigated for its pathological role in PD, but its physiological function remains ...
Nicole Rachinger, Nora Mittag, Ines Böhme-Schäfer, Wei Xiang, Silke Kuphal, Anja K. Bosserhoff   +5 more
openaire   +4 more sources

Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice

, 2001
Background: The presynaptic protein alpha-synuclein is involved in a range of neurodegenerative diseases. Here we analyze potential compensatory mechanisms in alpha-synuclein null mutant mice.
Specht, CG, Schoepfer, R, Schoepfer Ralf, Specht Christian G   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Synapsin Condensates Recruit alpha-Synuclein

Journal of Molecular Biology, 2021
Neurotransmission relies on the tight spatial and temporal regulation of the synaptic vesicle (SV) cycle. Nerve terminals contain hundreds of SVs that form tight clusters. These clusters represent a distinct liquid phase in which one component of the phase are SVs and the other synapsin 1, a highly abundant synaptic protein.
Hoffmann, Christian, Sansevrino, Roberto, Morabito, Giuseppe, Logan, Chinyere, Vabulas, R Martin, Ulusoy, Ayse, Ganzella, Marcelo, Milovanovic, Dragomir   +7 more
openaire   +5 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source