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Amyloid oligomers as on-pathway precursors or off-pathway competitors of fibrils
Frontiers in Molecular Biosciences, 2023 Amyloid Diseases involve the growth of disease specific proteins into amyloid fibrils and their deposition in protein plaques. Amyloid fibril formation is typically preceded by oligomeric intermediates.
Martin Muschol +2 more
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Reactions of a trans-diamminediaquaplatinum(II) complex with L-cysteine
Macedonian Journal of Chemistry and Chemical Engineering, 2021 The reaction of a trans-diamminediaquaplatinum(II) complex, trans-[Pt(15NH3)2(H2O)2]2+ (1), and L-cysteine (R–SH) has been performed to confirm the formation of the products in the solution.
Sutopo Hadi +4 more
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Frontiers in Allergy, 2023 Protein modifications such as oligomerization and tyrosine nitration alter the immune response to allergens and may contribute to the increasing prevalence of allergic diseases.
Janine Fröhlich-Nowoisky +4 more
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Synaptic Disruption by Soluble Oligomers in Patients with Alzheimer’s and Parkinson’s Disease
Biomedicines, 2022 Neurodegenerative diseases are the result of progressive dysfunction of the neuronal activity and subsequent neuronal death. Currently, the most prevalent neurodegenerative diseases are by far Alzheimer’s (AD) and Parkinson’s (PD) disease, affecting ...
Berenice A. Gutierrez, Agenor Limon
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Frontiers in Pharmacology, 2020 Oligomeric assembly of Amyloid-β (Aβ) is the main toxic species that contribute to early cognitive impairment in Alzheimer’s patients. Therefore, drugs that reduce the formation of Aβ oligomers could halt the disease progression.
Taweesak Tangrodchanapong +2 more
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Extracellular Alpha-Synuclein: Mechanisms for Glial Cell Internalization and Activation
Biomolecules, 2022 Alpha-synuclein (α-syn) is a small protein composed of 140 amino acids and belongs to the group of intrinsically disordered proteins. It is a soluble protein that is highly expressed in neurons and expressed at low levels in glial cells.
Cecilia Chavarría +2 more
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Proteostasis Response to Protein Misfolding in Controlled Hypertension
Cells, 2022 Hypertension is the most determinant risk factor for cardiovascular diseases. Early intervention and future therapies targeting hypertension mechanisms may improve the quality of life and clinical outcomes.
Manuel Teixeira +12 more
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The C291R Tau variant forms different types of protofibrils [PDF]
, 2020 Mutations in the MAPT gene can lead to disease-associated variants of tau. However, the pathological mechanisms behind these genetic tauopathies are poorly understood. Here, we characterized the aggregation stages and conformational changes of tau C291R,
Karikari, Thomas K. +2 more
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Neuropathology of the Alzheimer's continuum: an update
Free Neuropathology, 2020 Alzheimer’s disease (AD), the most common form of dementia worldwide, is a mixed proteinopathy (amyloid and tau). Originally defined as a clinicopathological entity, it is a heterogenous, multifactorial disorder, currently referred to as the Alzheimer’s ...
Kurt A. Jellinger
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Regulation of the aggregate stability for binary polymer-mineral dispersions [PDF]
Нанотехнологии в строительстве, 2023 : Introduction. In the binary dispersed systems of different origins (mineral and polymer) with particles differing in size by an order of magnitude, heterocoagulation is observed.
Valentina A. Poluektova +4 more
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