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Targeting Protein Aggregation in ALS [PDF]
BiomoleculesProteinopathies involve the abnormal accumulation of specific proteins. Maintaining the balance of the proteome is a finely regulated process managed by a complex network of cellular machinery responsible for protein synthesis, folding, and degradation ...
Michele Perni, Benedetta Mannini
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Protein aggregation in bacteria [PDF]
FEMS Microbiology Reviews, 2019 ABSTRACTProtein aggregation occurs as a consequence of perturbations in protein homeostasis that can be triggered by environmental and cellular stresses. The accumulation of protein aggregates has been associated with aging and other pathologies in eukaryotes, and in bacteria with changes in growth rate, stress resistance and virulence.
Frederic D Schramm +2 more
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Protein aggregation in neurodegenerative diseases [PDF]
Chinese Medical Journal. Neurodegenerative diseases constitute a group of chronic disorders characterized by the progressive loss of neurons. Major neurodegenerative conditions include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, frontotemporal lobar ...
Jiannan Wang +3 more
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Plant-Based Inhibitors of Protein Aggregation [PDF]
BiomoleculesThe assembly of amyloidogenic proteins and peptides into toxic oligomeric and fibrillar aggregates is closely connected to the onset and progression of more than 50 protein diseases, such as Alzheimer’s disease, Parkinson’s disease, prion disease, and ...
Olha Zhytniakivska +2 more
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Moderate Protein Processing: Elucidation of Thermal Aggregation and Gel Quality and Regulatory Strategies for Excessive Aggregation [PDF]
Shipin Kexue, 2023 Heat treatment can induce muscle protein denaturation and aggregation and eventually the sol-gel tradition of proteins. The aggregation rate, degree, morphology and pattern can affect the quality of protein gels.
HAN Zongyuan, SHAO Junhua, PAN Yanmo, CHENG Kaixing, SUN Qinxiu, WEI Shuai, XIA Qiuyu, WANG Zefu, LIU Shucheng
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Protein aggregate myopathies [PDF]
Neurology India, 2005 Protein aggregate myopathies (PAM) are an emerging group of muscle diseases characterized by structural abnormalities. Protein aggregate myopathies are marked by the aggregation of intrinsic proteins within muscle fibers and fall into four major groups or conditions: (1) desmin-related myopathies (DRM) that include desminopathies, a-B ...
M C, Sharma, H H, Goebel
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Amyloids and protein aggregation
Chemical Science, 2023 Sara Linse and Tuomas Knowles introduce the Chemical Science themed collection on the topic of amyloids and protein aggregation.
Sara Linse, Tuomas Knowles
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Protein aggregation and bioprocessing [PDF]
The AAPS Journal, 2006 Protein aggregation is a common issue encountered during manufacture of biotherapeutics. It is possible to influence the amount of aggregate produced during the cell culture and purification process by carefully controlling the environment (eg, media components) and implementing appropriate strategies to minimize the extent of aggregation.
Mary E M, Cromwell +2 more
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Increased Aggregation Is More Frequently Associated to Human Disease-Associated Mutations Than to Neutral Polymorphisms. [PDF]
PLoS Computational Biology, 2015 Protein aggregation is a hallmark of over 30 human pathologies. In these diseases, the aggregation of one or a few specific proteins is often toxic, leading to cellular degeneration and/or organ disruption in addition to the loss-of-function resulting ...
Greet De Baets +3 more
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α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies
Neural Regeneration Research, 2023 The misfolding and aggregation of α-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies, such as Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy.
Alessandra Bigi +2 more
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