Results 31 to 40 of about 432,033 (262)

The RNA-Binding Protein Scp160p Facilitates Aggregation of Many Endogenous Q/N-Rich Proteins

Cell Reports, 2018
Summary: The RNA-binding protein Scp160p is the yeast homolog of the conserved vigilin protein family. These proteins influence a variety of nuclear and cytoplasmic functions.
Matthew H.K. Cheng, Patrick C. Hoffmann, Mirita Franz-Wachtel, Carola Sparn, Charlotte Seng, Boris Maček, Ralf-Peter Jansen   +6 more
doaj   +1 more source

Dynamic fluctuations of protein-carbohydrate interactions promote protein aggregation. [PDF]

PLoS ONE, 2009
Protein-carbohydrate interactions are important for glycoprotein structure and function. Antibodies of the IgG class, with increasing significance as therapeutics, are glycosylated at a conserved site in the constant Fc region.
Vladimir Voynov, Naresh Chennamsetty, Veysel Kayser, Bernhard Helk, Kurt Forrer, Heidi Zhang, Cornelius Fritsch, Holger Heine, Bernhardt L Trout   +8 more
doaj   +1 more source

Production of prone‐to‐aggregate proteins [PDF]

FEBS Letters, 2013
Expression of recombinant proteins inEscherichia coli(E. coli) remains the most popular and cost‐effective method for producing proteins in basic research and for pharmaceutical applications. Despite accumulating experience and methodologies developed over the years, production of recombinant proteins prone to aggregate inE.
Lebendiker, Mario, Danieli, Tsafi
openaire   +2 more sources

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

eLife, 2022
A loss of the checkpoint kinase ataxia telangiectasia mutated (ATM) leads to impairments in the DNA damage response, and in humans causes cerebellar neurodegeneration, and an increased risk of cancer.
Wouter Huiting, Suzanne L Dekker, Joris CJ van der Lienden, Rafaella Mergener, Maiara K Musskopf, Gabriel V Furtado, Emma Gerrits, David Coit, Mehrnoosh Oghbaie, Luciano H Di Stefano, Hein Schepers, Maria AWH van Waarde-Verhagen, Suzanne Couzijn, Lara Barazzuol, John LaCava, Harm H Kampinga, Steven Bergink   +16 more
doaj   +1 more source

AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides

BMC Bioinformatics, 2007
Background Protein aggregation correlates with the development of several debilitating human disorders of growing incidence, such as Alzheimer's and Parkinson's diseases.
Vendrell Josep, Avilés Francesc X, de Groot Natalia S, Conchillo-Solé Oscar, Daura Xavier, Ventura Salvador   +5 more
doaj   +1 more source

Research Progress on the Effects of Parameters of Alkali Extraction and Acid Precipitation on the Denaturation, Aggregation, and Rheological Characteristics of Soybean Protein Isolate [PDF]

Shipin Kexue
pH, NaCl and temperature are important process parameters for the manufacturing of soybean protein isolate (SPI). pH and NaCl affect protein aggregation by modifying the surface charge and electrostatic repulsion, whereas temperature affects protein ...
MENG Ang, LUAN Binyu, GUO Boli, ZHANG Bo, YU Wenhua, CUI Kai
doaj   +1 more source

Pathological AT1R-B2R Protein Aggregation and Preeclampsia

Cells, 2021
Preeclampsia is one of the most frequent and severe complications of pregnancy. Symptoms of preeclampsia usually occur after 20 weeks of pregnancy and include hypertension and kidney dysfunction with proteinuria.
Ursula Quitterer, Said AbdAlla
doaj   +1 more source

Aging and the aggregating proteome

Frontiers in Genetics, 2012
For all organisms promoting protein homeostasis is a high priority in order to optimize cellular functions and resources. However, there is accumulating evidence that aging leads to a collapse in protein homeostasis and widespread non-disease protein ...
Della C David
doaj   +1 more source

The amyloid interactome: Exploring protein aggregation. [PDF]

PLoS ONE, 2017
Protein-protein interactions are the quintessence of physiological activities, but also participate in pathological conditions. Amyloid formation, an abnormal protein-protein interaction process, is a widespread phenomenon in divergent proteins and ...
Konstantina V Biza, Katerina C Nastou, Paraskevi L Tsiolaki, Chara V Mastrokalou, Stavros J Hamodrakas, Vassiliki A Iconomidou   +5 more
doaj   +1 more source

Adenosine Triphosphate (ATP) and Protein Aggregation in Age-Related Vision-Threatening Ocular Diseases

Metabolites, 2023
Protein aggregation is the etiopathogenesis of the three most profound vision-threatening eye diseases: age-related cataract, presbyopia, and age-related macular degeneration.
Jack V. Greiner, Thomas Glonek
doaj   +1 more source