Results 31 to 40 of about 737,709 (296)
Global analysis of protein aggregation in yeast during physiological conditions and arsenite stress
Biology Open, 2014 Protein aggregation is a widespread phenomenon in cells and associated with pathological conditions. Yet, little is known about the rules that govern protein aggregation in living cells. In this study, we biochemically isolated aggregation-prone proteins
Sebastian Ibstedt +3 more
doaj +1 more source
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease [PDF]
, 2015 Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown.
Andrey Y. Abramov +16 more
core +5 more sources
Cell Death via Lipid Peroxidation and Protein Aggregation Diseases
Biology, 2021 Lipid peroxidation of cellular membranes is a complicated cellular event, and it is both the cause and result of various diseases, such as ischemia-reperfusion injury, neurodegenerative diseases, and atherosclerosis.
Katsuya Iuchi +2 more
doaj +1 more source
The agrin gene codes for a family of basal lamina proteins that differ in function and distribution [PDF]
, 1992 We isolated two cDNAs that encode isoforms of agrin, the basal lamina protein that mediates the motor neuron-induced aggregation of acetylcholine receptors on muscle fibers at the neuromuscular junction.
Escher, G. +6 more
core +2 more sources
Amyloids and protein aggregation
Chemical Science, 2023 Sara Linse and Tuomas Knowles introduce the Chemical Science themed collection on the topic of amyloids and protein aggregation.
Sara Linse, Tuomas Knowles
openaire +2 more sources
Why and how protein aggregation has to be studied
Microbial Cell Factories, 2013 The understanding of protein aggregation is a central issue in different fields of protein science, from the heterologous protein production in biotechnology to amyloid aggregation in several neurodegenerative and systemic diseases.
Ami Diletta +3 more
doaj +1 more source
Protein folding disorders: Toward a basic biological paradigm [PDF]
, 2010 Mechanistic 'physics' models of protein folding fail to account for the observed spectrum of protein folding and aggregation disorders, suggesting that a more appropriately biological paradigm will be needed for understanding the etiology ...
Rodrick Wallace
core +3 more sources
Protein aggregation in bacteria [PDF]
FEMS Microbiology Reviews, 2019 ABSTRACTProtein aggregation occurs as a consequence of perturbations in protein homeostasis that can be triggered by environmental and cellular stresses. The accumulation of protein aggregates has been associated with aging and other pathologies in eukaryotes, and in bacteria with changes in growth rate, stress resistance and virulence.
Frederic D Schramm +2 more
openaire +3 more sources
An evolutionary trade-off between protein turnover rate and protein aggregation favors a higher aggregation propensity in fast degrading proteins. [PDF]
PLoS Computational Biology, 2011 We previously showed the existence of selective pressure against protein aggregation by the enrichment of aggregation-opposing 'gatekeeper' residues at strategic places along the sequence of proteins.
Greet De Baets +5 more
doaj +1 more source
eLife, 2022 A loss of the checkpoint kinase ataxia telangiectasia mutated (ATM) leads to impairments in the DNA damage response, and in humans causes cerebellar neurodegeneration, and an increased risk of cancer.
Wouter Huiting +16 more
doaj +1 more source