Results 11 to 20 of about 436,505 (303)
Cell Death via Lipid Peroxidation and Protein Aggregation Diseases
Biology, 2021 Lipid peroxidation of cellular membranes is a complicated cellular event, and it is both the cause and result of various diseases, such as ischemia-reperfusion injury, neurodegenerative diseases, and atherosclerosis.
Katsuya Iuchi +2 more
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Nanoparticles in relation to peptide and protein aggregation
International Journal of Nanomedicine, 2014 Masihuz Zaman, Ejaz Ahmad, Atiyatul Qadeer, Gulam Rabbani, Rizwan Hasan Khan Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India Abstract: Over the past two decades, there has been considerable research interest in the use of
Zaman M +4 more
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Polysorbates, peroxides, protein aggregation, and immunogenicity – a growing concern [PDF]
Journal of Excipients and Food ChemicalsAggregation can have a number of deleterious effects on biotherapeutics including the loss of efficacy, the induction of unwanted immunogenicity, altered pharmacokinetics, and reduced shelf life. Aggregation is ameliorated by the inclusion of surfactants
Edward T. Maggio
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Polysorbates, peroxides, protein aggregation, and immunogenicity – a growing concern [PDF]
Journal of Excipients and Food Chemicals, 2016 Aggregation can have a number of deleterious effects on biotherapeutics including the loss of efficacy, the induction of unwanted immunogenicity, altered pharmacokinetics, and reduced shelf life. Aggregation is ameliorated by the inclusion of surfactants
Edward T. Maggio
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Arsenic-induced protein aggregation and toxicity in Saccharomyces cerevisiae [PDF]
, 2022 Arsenic is prevalent in the environment and this toxic metalloid poses a substantial threat to human health with 100-200 million people worldwide estimated to be at risk.
Hua, Sansan
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A Conceptual Framework for Integrating Cellular Protein Folding, Misfolding and Aggregation
Life, 2021 How proteins properly fold and maintain solubility at the risk of misfolding and aggregation in the cellular environments still remains largely unknown.
Seong Il Choi, Baik L. Seong
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Computational and Structural Biotechnology Journal, 2020 Protein aggregation is a widespread phenomenon that stems from the establishment of non-native intermolecular contacts resulting in protein precipitation. Despite its deleterious impact on fitness, protein aggregation is a generic property of polypeptide
Jaime Santos +4 more
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When aggregation-induced emission meets protein aggregates [PDF]
National Science Review, 2021 There is an unmet demand for research tools to monitor the multistep protein aggregation process in live cells, a process that has been associated with a growing number of human diseases. Recently, AIEgens have been developed to directly monitor the entire protein aggregation process in test tubes and live cells.
Sicheng Tang, Songtao Ye, Xin Zhang
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Protein aggregation and neurodegeneration [PDF]
Methods, 2011 In 1997 Carrell and Lomas put forth the concept that many disorders, which appeared to be unlinked, arose from the same general mechanism that involved the abnormal unfolding and aggregation of various underlying proteins [1]. The flux of proteins through pathways for formation of amyloid-like aggregates was proposed to be the mechanism for ...
Katie J, Mayo, Douglas M, Cyr
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Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation
Frontiers in Aging Neuroscience, 2017 Aging is the most important risk factor for neurodegenerative diseases associated with pathological protein aggregation such as Alzheimer’s disease.
Nicole Groh +9 more
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