Results 11 to 20 of about 432,033 (262)
Protein Aggregate Myopathies [PDF]
Seminars in Pediatric Neurology, 2006 Protein aggregate myopathies (PAMs) based on the morphologic phenomenon of aggregation of proteins within muscle fibers may occur in children (selenoproteinopathies, actinopathies, and myosinopathies) or adults (certain myofibrillar myopathies and myosinopathies).
Hans H, Goebel, Harald D, Müller
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Amyloids and protein aggregation
Chemical Science, 2023 Sara Linse and Tuomas Knowles introduce the Chemical Science themed collection on the topic of amyloids and protein aggregation.
Sara Linse, Tuomas Knowles
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Protein aggregation and bioprocessing [PDF]
The AAPS Journal, 2006 Protein aggregation is a common issue encountered during manufacture of biotherapeutics. It is possible to influence the amount of aggregate produced during the cell culture and purification process by carefully controlling the environment (eg, media components) and implementing appropriate strategies to minimize the extent of aggregation.
Mary E M, Cromwell +2 more
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Protein aggregation in bacteria [PDF]
FEMS Microbiology Reviews, 2019 ABSTRACTProtein aggregation occurs as a consequence of perturbations in protein homeostasis that can be triggered by environmental and cellular stresses. The accumulation of protein aggregates has been associated with aging and other pathologies in eukaryotes, and in bacteria with changes in growth rate, stress resistance and virulence.
Frederic D Schramm +2 more
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Protein aggregation and neurodegeneration [PDF]
Methods, 2011 In 1997 Carrell and Lomas put forth the concept that many disorders, which appeared to be unlinked, arose from the same general mechanism that involved the abnormal unfolding and aggregation of various underlying proteins [1]. The flux of proteins through pathways for formation of amyloid-like aggregates was proposed to be the mechanism for ...
Katie J, Mayo, Douglas M, Cyr
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Protein aggregation in silico [PDF]
Trends in Biotechnology, 2007 Protein aggregation is a challenge to the successful manufacture of protein therapeutics; it can impose severe limitations on purification yields and compromise formulation stability. Advances in computer power, and the wealth of computational studies pertaining to protein folding, have facilitated the development of molecular simulation as a tool to ...
Troy, Cellmer +3 more
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Aggregation is a Context-Dependent Constraint on Protein Evolution
Frontiers in Molecular Biosciences, 2021 Solubility is a requirement for many cellular processes. Loss of solubility and aggregation can lead to the partial or complete abrogation of protein function. Thus, understanding the relationship between protein evolution and aggregation is an important
Michele Monti +9 more
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When aggregation-induced emission meets protein aggregates [PDF]
National Science Review, 2021 There is an unmet demand for research tools to monitor the multistep protein aggregation process in live cells, a process that has been associated with a growing number of human diseases. Recently, AIEgens have been developed to directly monitor the entire protein aggregation process in test tubes and live cells.
Sicheng Tang, Songtao Ye, Xin Zhang
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Lipid oxidation in foods and its implications on proteins
Frontiers in Nutrition, 2023 Lipids in foods are sensitive to various environmental conditions. Under light or high temperatures, free radicals could be formed due to lipid oxidation, leading to the formation of unstable food system.
Lianxin Geng +3 more
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An in vivo platform to select and evolve aggregation-resistant proteins
Nature Communications, 2020 Protein aggregation remains a significant challenge for manufacturing of protein biopharmaceuticals. Here, the authors demonstrate the use of directed evolution and an assay for in vivo innate protein aggregation-propensity to generate aggregation ...
Jessica S. Ebo +14 more
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