Results 21 to 30 of about 432,033 (262)
A3DyDB: exploring structural aggregation propensities in the yeast proteome
Microbial Cell Factories, 2023 Background The budding yeast Saccharomyces cerevisiae (S. cerevisiae) is a well-established model system for studying protein aggregation due to the conservation of essential cellular structures and pathways found across eukaryotes.
Javier Garcia-Pardo +6 more
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Frontiers in Bioengineering and Biotechnology, 2023 Protein aggregation is a major challenge in the development of therapeutic monoclonal antibodies (mAbs). Several stressors can cause protein aggregation, including temperature shifts, mechanical forces, freezing-thawing cycles, oxidants, reductants, and ...
Qiang Wu +11 more
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Global analysis of protein aggregation in yeast during physiological conditions and arsenite stress
Biology Open, 2014 Protein aggregation is a widespread phenomenon in cells and associated with pathological conditions. Yet, little is known about the rules that govern protein aggregation in living cells. In this study, we biochemically isolated aggregation-prone proteins
Sebastian Ibstedt +3 more
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Mutational probing of protein aggregates to design aggregation‐resistant proteins [PDF]
FEBS Open Bio, 2016 Characterization of amorphous protein aggregates may offer insights into the process of aggregation. Eleven single amino acid mutants of lipase (LipA of Bacillus subtilis) were subjected to temperature‐induced aggregation, and the resultant aggregates were characterized for recovery of activity in the presence of guanidinium chloride (GdmCl).
Mohamad Zahid Kamal +4 more
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Protein aggregates in Huntington's disease [PDF]
Experimental Neurology, 2012 Huntington's disease (HD) is an incurable neurodegenerative disease characterized by abnormal motor movements, personality changes, and early death. HD is caused by a mutation in the IT-15 gene that expands abnormally the number of CAG nucleotide repeats.
Arrasate, Montserrat, Finkbeiner, Steven
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Why and how protein aggregation has to be studied
Microbial Cell Factories, 2013 The understanding of protein aggregation is a central issue in different fields of protein science, from the heterologous protein production in biotechnology to amyloid aggregation in several neurodegenerative and systemic diseases.
Ami Diletta +3 more
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Cell Death via Lipid Peroxidation and Protein Aggregation Diseases
Biology, 2021 Lipid peroxidation of cellular membranes is a complicated cellular event, and it is both the cause and result of various diseases, such as ischemia-reperfusion injury, neurodegenerative diseases, and atherosclerosis.
Katsuya Iuchi +2 more
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An evolutionary trade-off between protein turnover rate and protein aggregation favors a higher aggregation propensity in fast degrading proteins. [PDF]
PLoS Computational Biology, 2011 We previously showed the existence of selective pressure against protein aggregation by the enrichment of aggregation-opposing 'gatekeeper' residues at strategic places along the sequence of proteins.
Greet De Baets +5 more
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Tracking protein aggregate interactions [PDF]
Prion, 2011 Amyloid fibrils share a structural motif consisting of highly ordered β-sheets aligned perpendicular to the fibril axis ( 1, 2) . At each fibril end, β-sheets provide a template for recruiting and converting monomers ( 3) . Various amyloid fibrils often occur in the same individual, yet whether distinct protein aggregates aid or inhibit the assembly of
Nilsson, K. Peter R. +2 more
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Folding and aggregation of designed proteins [PDF]
Proceedings of the National Academy of Sciences, 1998 Protein aggregation is studied by following the simultaneous folding of two designed identical 20-letter amino acid chains within the framework of a lattice model and using Monte Carlo simulations. It is found that protein aggregation is determined by elementary structures (partially folded intermediates) controlled by local contacts among some of the ...
Broglia R. A. +4 more
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