Results 21 to 30 of about 436,505 (303)
Protein aggregation in silico [PDF]
Trends in Biotechnology, 2007 Protein aggregation is a challenge to the successful manufacture of protein therapeutics; it can impose severe limitations on purification yields and compromise formulation stability. Advances in computer power, and the wealth of computational studies pertaining to protein folding, have facilitated the development of molecular simulation as a tool to ...
Troy, Cellmer +3 more
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, 2023 Protein aggregation is implicated in multiple diseases, so-called proteinopathies, ranging from neurodegenerative disorders such as Alzheimer\u27s disease and Parkinson\u27s disease (PD) to type 2 diabetes mellitus and sickle cell disease (SCD).
Nuno, Galamba, Gabriel, Martins
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Computational methods to predict protein aggregation [PDF]
, 2022 Altres ajuts: acords transformatius de la UABIn most cases, protein aggregation stems from the establishment of non-native intermolecular contacts.
Navarro, Susanna, Ventura, Salvador
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Aggregation of polyQ proteins is increased upon yeast aging and affected by Sir2 and Hsf1: novel quantitative biochemical and microscopic assays. [PDF]
PLoS ONE, 2012 Aging-related neurodegenerative disorders, such as Parkinson's, Alzheimer's and Huntington's diseases, are characterized by accumulation of protein aggregates in distinct neuronal cells that eventually die. In Huntington's disease, the protein huntingtin
Aviv Cohen +3 more
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Mechanistic insights of protein aggregation at interfaces
, 2021 Roberts, Christopher J.Furst, Eric M.Monoclonal antibodies (MAbs) continue to be the largest selling class of therapeutic biologics. The success of MAb therapeutics is attributed to their potency, specificity, and ability to be engineered for different ...
Wood, Caitlin V.
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Aggregation is a Context-Dependent Constraint on Protein Evolution
Frontiers in Molecular Biosciences, 2021 Solubility is a requirement for many cellular processes. Loss of solubility and aggregation can lead to the partial or complete abrogation of protein function. Thus, understanding the relationship between protein evolution and aggregation is an important
Michele Monti +9 more
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Mutational probing of protein aggregates to design aggregation‐resistant proteins [PDF]
FEBS Open Bio, 2016 Characterization of amorphous protein aggregates may offer insights into the process of aggregation. Eleven single amino acid mutants of lipase (LipA of Bacillus subtilis) were subjected to temperature‐induced aggregation, and the resultant aggregates were characterized for recovery of activity in the presence of guanidinium chloride (GdmCl).
Mohamad Zahid Kamal +4 more
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Lipid oxidation in foods and its implications on proteins
Frontiers in Nutrition, 2023 Lipids in foods are sensitive to various environmental conditions. Under light or high temperatures, free radicals could be formed due to lipid oxidation, leading to the formation of unstable food system.
Lianxin Geng +3 more
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Protein aggregates in Huntington's disease [PDF]
Experimental Neurology, 2012 Huntington's disease (HD) is an incurable neurodegenerative disease characterized by abnormal motor movements, personality changes, and early death. HD is caused by a mutation in the IT-15 gene that expands abnormally the number of CAG nucleotide repeats.
Arrasate, Montserrat, Finkbeiner, Steven
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Tracking protein aggregate interactions [PDF]
Prion, 2011 Amyloid fibrils share a structural motif consisting of highly ordered β-sheets aligned perpendicular to the fibril axis ( 1, 2) . At each fibril end, β-sheets provide a template for recruiting and converting monomers ( 3) . Various amyloid fibrils often occur in the same individual, yet whether distinct protein aggregates aid or inhibit the assembly of
Nilsson, K. Peter R. +2 more
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