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On the Role of the Immunoproteasome in Protein Homeostasis [PDF]
Cells, 2021 Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation.
Michael Basler, Marcus Groettrup
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Actin dynamics in protein homeostasis [PDF]
Bioscience Reports, 2022 Abstract Cell homeostasis is maintained in all organisms by the constant adjustment of cell constituents and organisation to account for environmental context. Fine-tuning of the optimal balance of proteins for the conditions, or protein homeostasis, is critical to maintaining cell homeostasis.
Thomas D. Williams, Adrien Rousseau
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Sorting Nexins in Protein Homeostasis [PDF]
Cells, 2020 Sorting nexins (SNXs) are a highly conserved membrane-associated protein family that plays a role in regulating protein homeostasis. This family of proteins is unified by their characteristic phox (PX) phosphoinositides binding domain. Along with binding to membranes, this family of SNXs also comprises a diverse array of protein-protein interaction ...
Sarah E Hanley, Katrina F Cooper
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Protein degradation and iron homeostasis
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 Regulation of both systemic and cellular iron homeostasis requires the capacity to sense iron levels and appropriately modify the expression of iron metabolism genes. These responses are coordinated through the efforts of several key regulatory factors including F-box and Leucine-rich Repeat Protein 5 (FBXL5), Iron Regulatory Proteins (IRPs), Hypoxia ...
Thompson, Joel W., Bruick, Richard K.
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Protein homeostasis and synaptic plasticity [PDF]
The EMBO Journal, 2010 It is clear that de novo protein synthesis has an important function in synaptic transmission and plasticity. A substantial amount of work has shown that mRNA translation in the hippocampus is spatially controlled and that dendritic protein synthesis is required for different forms of long-term synaptic plasticity.
Cajigas, I., Will, T., Schuman, E.
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Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?
Open Biology, 2021 Genome instability and loss of protein homeostasis are hallmark events of age-related diseases that include neurodegeneration. Several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic ...
Anna Ainslie +3 more
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pSTAT3 transactivates EGFR in maintaining EGFR protein homeostasis and EGFR-TKI resistance [PDF]
Acta Biochimica et Biophysica SinicaEGFR protein trafficking is critical for regulating multiple biological processes, including cell growth and survival. However, how EGFR protein homeostasis is maintained remains unclear.
Ao Juan +10 more
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Single-cell expression predicts neuron-specific protein homeostasis networks [PDF]
Open BiologyThe protein homeostasis network keeps proteins in their correct shapes and avoids unwanted aggregation. In turn, the accumulation of aberrantly misfolded proteins has been directly associated with the onset of ageing-associated neurodegenerative diseases
Sebastian Pechmann
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Mechanisms of Endoplasmic Reticulum Protein Homeostasis in Plants [PDF]
International Journal of Molecular Sciences, 2023 Linchuan Liu +2 more
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Organismal Protein Homeostasis Mechanisms [PDF]
Genetics, 2020 Abstract Sustaining a healthy proteome is a lifelong challenge for each individual cell of an organism. However, protein homeostasis or proteostasis is constantly jeopardized since damaged proteins accumulate under proteotoxic stress that originates from ever-changing metabolic, environmental, and pathological conditions. Proteostasis is
Hoppe, Thorsten, Cohen, Ehud
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