Results 1 to 10 of about 1,938,524 (161)
On the Role of the Immunoproteasome in Protein Homeostasis
Cells, 2021 Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation.
Michael Basler, Marcus Groettrup
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Lipid Homeostasis and Its Links With Protein Misfolding Diseases
Frontiers in Molecular Neuroscience, 2022 The maintenance of lipid homeostasis is essential for the normal functioning of living organisms. Alterations of the lipid homeostasis system remodel the composition of the lipidome, potentially leading to the formation of toxic lipid species.
Michele Vendruscolo
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Circadian Reprogramming of Protein Homeostasis and Glycolipid Metabolism in Diabetic Nephropathy [PDF]
FASEB BioAdvancesDysfunction of the circadian clock has been implicated in the pathogenesis of various diseases, including metabolic disorders, inflammatory conditions, and cancer.
Xiao‐Qian Li +8 more
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Single-cell expression predicts neuron-specific protein homeostasis networks [PDF]
Open BiologyThe protein homeostasis network keeps proteins in their correct shapes and avoids unwanted aggregation. In turn, the accumulation of aberrantly misfolded proteins has been directly associated with the onset of ageing-associated neurodegenerative diseases
Sebastian Pechmann
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pSTAT3 transactivates EGFR in maintaining EGFR protein homeostasis and EGFR-TKI resistance [PDF]
Acta Biochimica et Biophysica SinicaEGFR protein trafficking is critical for regulating multiple biological processes, including cell growth and survival. However, how EGFR protein homeostasis is maintained remains unclear.
Ao Juan +10 more
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Mechanisms of Endoplasmic Reticulum Protein Homeostasis in Plants [PDF]
International Journal of Molecular Sciences, 2023 Linchuan Liu +2 more
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Cells, 2022 Ribosomes within a cell are commonly viewed as biochemically homogenous RNA–protein super-complexes performing identical functions of protein synthesis.
Wenzhu Li +6 more
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Targeting of client proteins to the VCP/p97/Cdc48 unfolding machine
Frontiers in Molecular Biosciences, 2023 The AAA+ ATPase p97 (also called VCP or Cdc48) is a major protein unfolding machine with hundreds of clients in diverse cellular pathways that are critical for cell homeostasis, proliferation and signaling. In this review, we summarize recent advances in
Hemmo Meyer, Johannes van den Boom
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Structure of the human marker of self 5-transmembrane receptor CD47
Nature Communications, 2021 CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the ...
Gustavo Fenalti +15 more
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Frontiers in Microbiology, 2023 The protein homeostasis network ensures a proper balance between synthesis, folding, and degradation of all cellular proteins. DnaK and trigger factor (TF) are ubiquitous bacterial molecular chaperones that assist in protein folding, as well as ...
Judith Matavacas +2 more
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