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On the Role of the Immunoproteasome in Protein Homeostasis [PDF]

Cells, 2021
Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation.
Michael Basler, Marcus Groettrup
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Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?

Open Biology, 2021
Genome instability and loss of protein homeostasis are hallmark events of age-related diseases that include neurodegeneration. Several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic ...
Anna Ainslie, Wouter Huiting, Lara Barazzuol, Steven Bergink   +3 more
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Differential Paralog-Specific Expression of Multiple Small Subunit Proteins Cause Variations in Rpl42/eL42 Incorporation in Ribosome in Fission Yeast

Cells, 2022
Ribosomes within a cell are commonly viewed as biochemically homogenous RNA–protein super-complexes performing identical functions of protein synthesis.
Wenzhu Li, Jing Zhang, Wenpeng Cheng, Yuze Li, Jinwen Feng, Jun Qin, Xiangwei He   +6 more
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Targeting of client proteins to the VCP/p97/Cdc48 unfolding machine

Frontiers in Molecular Biosciences, 2023
The AAA+ ATPase p97 (also called VCP or Cdc48) is a major protein unfolding machine with hundreds of clients in diverse cellular pathways that are critical for cell homeostasis, proliferation and signaling. In this review, we summarize recent advances in
Hemmo Meyer, Johannes van den Boom
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Structure of the human marker of self 5-transmembrane receptor CD47

Nature Communications, 2021
CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the ...
Gustavo Fenalti, Nicolas Villanueva, Mark Griffith, Barbra Pagarigan, Sirish Kaushik Lakkaraju, Richard Y.-C. Huang, Nadia Ladygina, Alok Sharma, David Mikolon, Mahan Abbasian, Jeffrey Johnson, Haralambos Hadjivassiliou, Dan Zhu, Philip P. Chamberlain, Ho Cho, Kandasamy Hariharan   +15 more
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Bacillus subtilis forms twisted cells with cell wall integrity defects upon removal of the molecular chaperones DnaK and trigger factor

Frontiers in Microbiology, 2023
The protein homeostasis network ensures a proper balance between synthesis, folding, and degradation of all cellular proteins. DnaK and trigger factor (TF) are ubiquitous bacterial molecular chaperones that assist in protein folding, as well as ...
Judith Matavacas, Joel Hallgren, Claes von Wachenfeldt   +2 more
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Yeast Bromodomain Factor 1 and Its Human Homolog TAF1 Play Conserved Roles in Promoting Homologous Recombination

Advanced Science, 2021
Histone acetylation is a key histone post‐translational modification that shapes chromatin structure, dynamics, and function. Bromodomain (BRD) proteins, the readers of acetyl‐lysines, are located in the center of the histone acetylation‐signaling ...
Haoyang Peng, Simin Zhang, Yihan Peng, Shuangyi Zhu, Xin Zhao, Xiaocong Zhao, Shuangshuang Yang, Guangxue Liu, Yang Dong, Xiaoli Gan, Qing Li, Xinghua Zhang, Huadong Pei, Xuefeng Chen   +13 more
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Bacterial Protein Homeostasis Disruption as a Therapeutic Intervention

Frontiers in Molecular Biosciences, 2021
Cells have evolved a complex molecular network, collectively called the protein homeostasis (proteostasis) network, to produce and maintain proteins in the appropriate conformation, concentration and subcellular localization.
Laleh Khodaparast, Laleh Khodaparast, Guiqin Wu, Guiqin Wu, Ladan Khodaparast, Ladan Khodaparast, Béla Z. Schmidt, Béla Z. Schmidt, Frederic Rousseau, Frederic Rousseau, Joost Schymkowitz, Joost Schymkowitz   +11 more
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Autophagy Impairment in App Knock-in Alzheimer’s Model Mice

Frontiers in Aging Neuroscience, 2022
Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-β peptide (Aβ) amyloidosis. Amyloid precursor protein (APP) knock-in mice exhibit robust Aβ pathology, providing possibilities to determine its effect on protein
Richeng Jiang, Richeng Jiang, Makoto Shimozawa, Johanna Mayer, Simone Tambaro, Rakesh Kumar, Axel Abelein, Bengt Winblad, Bengt Winblad, Nenad Bogdanovic, Per Nilsson   +10 more
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Research progress of integrated stress response in pathogenesis of Alzheimer's disease

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Integrated stress response (ISR) is a cellular adaptive response induced by stress, which is strictly regulated by multiple phosphokinases, phosphatases and other proteins to maintain protein homeostasis.
SUN Hui, JIN Hongfu, GUO Shenrui, FENG Yiyuan, YIN Yafu, WANG Hui, CHENG Weiwei   +6 more
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