Results 31 to 40 of about 1,575,616 (301)

Calcium as a crucial cofactor for low density lipoprotein receptor folding in the endoplasmic reticulum [PDF]

, 2010
The family of low density lipoprotein (LDL) receptors mediate uptake of a plethora of ligands from the circulation and couple this to signaling, thereby performing a crucial role in physiological processes including embryonic development, cancer ...
Sub Cellular Protein Chemistry, Pena, F., van Zadelhoff, G., Braakman, L.J., Cellular Protein Chemistry, Dep Scheikunde, Jansens, A.   +6 more
core   +1 more source

A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation. [PDF]

, 2010
E-cadherin is a major component of adherens junctions. Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed intestinal homeostasis and barrier function.
Trülzsch, Konrad, Eckhard Wolf, Sylvia Steininger, Hirschi Benjamin, Müller-Höcker Josef, Frank T Kolligs, Allgäuer, Michael, Marlon R. Schneider, Schneider Marlon R., Dahlhoff, Maik, Gerhard Markus, Schneider, Marlon R., Konrad Trülzsch, Vogelmann, Roger, Maik Dahlhoff, Müller-Höcker, Josef, Michael Allgäuer, Allgäuer Michael, Horst David, Roger Vogelmann, Markus Gerhard, Horst, David, Frank T. Kolligs, Wolf Eckhard, Dahlhoff Maik, Benjamin Hirschi, Kolligs, Frank T., David Horst, Trülzsch Konrad, Wolf, Eckhard, Josef Müller-Höcker, Kolligs Frank T., Marlon R Schneider, Hirschi, Benjamin, Steininger Sylvia, Gerhard, Markus, Steininger, Sylvia, Vogelmann Roger   +37 more
core   +1 more source

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis [PDF]

, 2012
Peer ...
Welch, A, Robert Judson (279511), Mirela Delibegović, Louise Grant (181930), Grant Louise, Emma K Lees, Judson, R, Andy Welch (181948), Göransson, Olga, Goransson, O, Barbara B Kahn, George D. Mcilroy (181939), Carl Owen (181917), Mcilroy George D., Kendra K. Bence (149032), Olga Göransson, Mody Nimesh, Benjamin G. Neel (162598), Lees, Emma K, Kahn Barbara B., Louise Grant, Nimesh Mody (181963), Bence, Kendra K., Neel Benjamin G., Bence, KK, Grant, L, Owen, C, Mody, Nimesh, Mcilroy, George D, Neel, BG, Owen, Carl, Welch Andy, Olga Göransson (181943), Agouni, Abdelali, Neel, Benjamin G, Abdelali Agouni, Czopek Alicja, Kahn, Barbara B, Neel, Benjamin G., Bence Kendra K., Agouni, A, Lees, Emma K., McIlroy, George, Bence, Kendra K, Abdelali Agouni (181926), Nimesh Mody, Göransson Olga, Lund University., Judson, Robert, Czopek, Alicja, Mody, N, Czopek, A, Kendra K Bence, Mirela Delibegović (181968), Andy Welch, George D Mcilroy, Alicja Czopek (181921), Grant, Louise, Lees, EK, Benjamin G. Neel, Barbara B. Kahn, Delibegovic, Mirela, Barbara B. Kahn (181955), Agouni Abdelali, Kahn, Barbara B., Judson Robert, Göransson, Olga,, Mcilroy, GD, Welch, Andy, Emma K. Lees (181936), Lees Emma K., Robert Judson, Benjamin G Neel, Delibegovic, M, Kendra K. Bence, Delibegović Mirela, Carl Owen, Owen Carl, Mcilroy, George D., Emma K. Lees, Alicja Czopek, Kahn, BB, George D. Mcilroy   +82 more
core   +1 more source

Low-carbohydrate diets affect energy balance and fuel homeostasis differentially in lean and obese rats [PDF]

, 2006
In parallel with increased prevalence of overweight people in affluent societies are individuals trying to lose weight, often using low-carbohydrate diets.
van Dijk, G., Dijk, G. van,, Morens, C., Morens, C.,, Scheurink, A.J.W.,, G. van Dijk, C. Morens, Sirot, V.,, Scheurink, A. J. W., V. Sirot, A. J. W. Scheurink, van Dijk, G.; id_orcid, Sirot, V.   +12 more
core   +1 more source

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System

Cell Reports, 2016
Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration.
John D. Murdoch, Christine M. Rostosky, Sindhuja Gowrisankaran, Amandeep S. Arora, Sandra-Fausia Soukup, Ramon Vidal, Vincenzo Capece, Siona Freytag, Andre Fischer, Patrik Verstreken, Stefan Bonn, Nuno Raimundo, Ira Milosevic   +12 more
doaj   +1 more source

Extracellular matrix fragmentation in young, healthy cartilaginous tissues [PDF]

European Cells & Materials, 2018
Although the composition and structure of cartilaginous tissues is complex, collagen II fibrils and aggrecan are the most abundant assemblies in both articular cartilage (AC) and the nucleus pulposus (NP) of the intervertebral disc (IVD).
RJ Craddock, NW Hodson, M Ozols, T Shearer, JA Hoyland, MJ Sherratt   +5 more
doaj   +1 more source

Lipin proteins and metabolic homeostasis

Journal of Lipid Research, 2009
The lipin protein family, consisting of three members, was first identified early this century. In the last few years, the lipin proteins have been shown to have important roles in glycerolipid biosynthesis and gene regulation, and mutations in the corresponding genes cause lipodystrophy, myoglobinuria, and inflammatory disorders.
Karen Reue, Jennifer R. Dwyer
openaire   +3 more sources

Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]

, 2007
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Hisadome, Kazunari, Michael L. J. Ashford, Smith, Mark A., Helen Heffron, Mark A. Smith, Al-Qassab, Hind, Kazunari Hisadome, Withers, Dominic J., Hind Al‐Qassab, Dominic J. Withers, Ashford, Michael L. J.; id_orcid, Heffron, Helen   +11 more
core   +1 more source

Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease

Cell Reports, 2016
The balance between protein synthesis and protein breakdown is a major determinant of protein homeostasis, and loss of protein homeostasis is one of the hallmarks of aging.
Marieke Visscher, Sasha De Henau, Mattheus H.E. Wildschut, Robert M. van Es, Ineke Dhondt, Helen Michels, Patrick Kemmeren, Ellen A. Nollen, Bart P. Braeckman, Boudewijn M.T. Burgering, Harmjan R. Vos, Tobias B. Dansen   +11 more
doaj   +1 more source

Cellular maintenance of nuclear protein homeostasis [PDF]

Cellular and Molecular Life Sciences, 2013
The accumulation and aggregation of misfolded proteins is the primary hallmark for more than 45 human degenerative diseases. These devastating disorders include Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis. Over 15 degenerative diseases are associated with the aggregation of misfolded proteins specifically in the nucleus of
Pamela S. Gallagher, Michelle L. Oeser, Ayelet-chen Abraham, Daniel Kaganovich, Richard G. Gardner   +4 more
openaire   +2 more sources