Results 31 to 40 of about 5,395,698 (297)

Protein degradation and iron homeostasis

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012
Regulation of both systemic and cellular iron homeostasis requires the capacity to sense iron levels and appropriately modify the expression of iron metabolism genes. These responses are coordinated through the efforts of several key regulatory factors including F-box and Leucine-rich Repeat Protein 5 (FBXL5), Iron Regulatory Proteins (IRPs), Hypoxia ...
Thompson, Joel W., Bruick, Richard K.
openaire   +2 more sources

Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]

, 2007
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Hisadome, Kazunari, Michael L. J. Ashford, Smith, Mark A., Helen Heffron, Mark A. Smith, Al-Qassab, Hind, Kazunari Hisadome, Withers, Dominic J., Hind Al‐Qassab, Dominic J. Withers, Ashford, Michael L. J.; id_orcid, Heffron, Helen   +11 more
core   +1 more source

Cellular maintenance of nuclear protein homeostasis [PDF]

Cellular and Molecular Life Sciences, 2013
The accumulation and aggregation of misfolded proteins is the primary hallmark for more than 45 human degenerative diseases. These devastating disorders include Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis. Over 15 degenerative diseases are associated with the aggregation of misfolded proteins specifically in the nucleus of
Pamela S. Gallagher, Michelle L. Oeser, Ayelet-chen Abraham, Daniel Kaganovich, Richard G. Gardner   +4 more
openaire   +2 more sources

Protein homeostasis imprinting across evolution [PDF]

NAR Genomics and Bioinformatics, 2020
Abstract Protein homeostasis (a.k.a. proteostasis) is associated with the primary functions of life, and therefore with evolution. However, it is unclear how cellular proteostasis machines have evolved to adjust protein biogenesis needs to environmental constraints. Herein, we describe a novel computational approach, based on semantic
Koutsandreas, Thodoris, Felden, Brice, Chevet, Eric, Chatziioannou, Aristotelis   +3 more
openaire   +2 more sources

Protein Homeostasis at the Plasma Membrane

Physiology, 2014
The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving
Pirjo M, Apaja, Gergely L, Lukacs
openaire   +3 more sources

Protein homeostasis networks in physiology and disease [PDF]

Current Opinion in Cell Biology, 2011
Although most text books of biochemistry describe the process of protein folding to a three dimensional native state as an intrinsic property of the primary sequence, it is becoming increasingly clear that this process can go wrong in an almost infinite number of ways.
Hetz Flores, Claudio, Glimcher, Laurie H.   +1 more
openaire   +5 more sources

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System

Cell Reports, 2016
Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration.
John D. Murdoch, Christine M. Rostosky, Sindhuja Gowrisankaran, Amandeep S. Arora, Sandra-Fausia Soukup, Ramon Vidal, Vincenzo Capece, Siona Freytag, Andre Fischer, Patrik Verstreken, Stefan Bonn, Nuno Raimundo, Ira Milosevic   +12 more
doaj   +1 more source

Hepatocyte-specific deletion of peroxisomal protein PEX13 results in disrupted iron homeostasis

, 2020
Peroxisomes are organelles, abundant in the liver, involved in a variety of cellular functions, including fatty acid metabolism, plasmalogen synthesis and metabolism of reactive oxygen species.
Secondes, Eriza S., Subramaniam, V. Nathan, Melino, Michelle, Crane, Denis, Subramaniam, V Nathan, Secondes, Eriza S, Bhatia, Maneet, Rishi, Gautam   +7 more
core   +1 more source

Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease

Cell Reports, 2016
The balance between protein synthesis and protein breakdown is a major determinant of protein homeostasis, and loss of protein homeostasis is one of the hallmarks of aging.
Marieke Visscher, Sasha De Henau, Mattheus H.E. Wildschut, Robert M. van Es, Ineke Dhondt, Helen Michels, Patrick Kemmeren, Ellen A. Nollen, Bart P. Braeckman, Boudewijn M.T. Burgering, Harmjan R. Vos, Tobias B. Dansen   +11 more
doaj   +1 more source

Extracellular matrix fragmentation in young, healthy cartilaginous tissues [PDF]

European Cells & Materials, 2018
Although the composition and structure of cartilaginous tissues is complex, collagen II fibrils and aggrecan are the most abundant assemblies in both articular cartilage (AC) and the nucleus pulposus (NP) of the intervertebral disc (IVD).
RJ Craddock, NW Hodson, M Ozols, T Shearer, JA Hoyland, MJ Sherratt   +5 more
doaj   +1 more source