Results 41 to 50 of about 5,395,698 (297)
Regulation of protein homeostasis in acute and chronic stress [PDF]
, 2019 The balance between protein production, folding, transport, assembly and the timely degradation of proteins is defined as protein homeostasis. This process is controlled by a network of protein quality control (PQC) that includes molecular chaperone and ...
Wu, Di
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Smurfs in Protein Homeostasis, Signaling, and Cancer [PDF]
Frontiers in Oncology, 2018 Protein ubiquitination is an evolutionary conserved highly-orchestrated enzymatic cascade essential for normal cellular functions and homeostasis maintenance. This pathway relies on a defined set of cellular enzymes, among them, substrate-specific E3 ubiquitin ligases (E3s). These ligases are the most critical players, as they define the spatiotemporal
Praveen Koganti +2 more
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Bio-ProtocolAccurate measurement of protein translation rates is crucial for understanding cellular processes and disease mechanisms. However, existing methods for quantifying translation rates in yeast cells are limited.
Mainak Jha, Koyeli Mapa
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Prions, protein homeostasis, and phenotypic diversity [PDF]
Trends in Cell Biology, 2010 Prions are fascinating but often misunderstood protein aggregation phenomena. The traditional association of the mammalian prion protein with disease has overshadowed a potentially more interesting attribute of prions: their ability to create protein-based molecular memories.
Lindquist, Susan +2 more
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Protein folding, protein homeostasis, and cancer [PDF]
Chinese Journal of Cancer, 2011 Proteins fold into their functional 3-dimensional structures from a linear amino acid sequence. In vitro this process is spontaneous; while in vivo it is orchestrated by a specialized set of proteins, called chaperones. Protein folding is an ongoing cellular process, as cellular proteins constantly undergo synthesis and degradation. Here emerging links
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Mutational analysis of the AtNUDT7 Nudix hydrolase from Arabidopsis thaliana reveals residues required for protein quaternary structure formation and activity. [PDF]
, 2009 Arabidopsis thaliana AtNUDT7, a homodimeric Nudix hydrolase active on ADP-ribose and NADH, exerts negative control on the major signaling complex involved in plant defense activation and programmed cell death.
Goch, Grażyna +6 more
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Aneuploidy: implications for protein homeostasis and disease [PDF]
Disease Models & Mechanisms, 2014 It has long been appreciated that aneuploidy – in which cells possess a karyotype that is not a multiple of the haploid complement – has a substantial impact on human health, but its effects at the subcellular level have only recently become a focus of investigation.
Oromendia, Ana Belen, Amon, Angelika B
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Journal of Cardiovascular Development and Disease, 2023 Dilated cardiomyopathy (DCM) is a common heart muscle disorder that frequently leads to heart failure, arrhythmias, and death. While DCM is often heritable, disease-causing mutations are identified in only ~30% of cases.
Inken G. Huttner +11 more
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ANKZF1 helps to eliminate stress-damaged mitochondria by LC3-mediated mitophagy
Cell Death DiscoveryMitochondria, the double membrane-bound organelles of endosymbiotic origin, are crucial centers for cellular energy production and several essential metabolic pathways.
Mudassar Ali, Anjali, Koyeli Mapa
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Actin dynamics regulate proteasome homeostasis [PDF]
, 2022 Cells require thousands of unique proteins to be in the right place, at the right time, in the right amounts and with the right modifications. They do this through several processes collectively known as protein homeostasis.
Rousseau, Adrien; id_orcid +3 more
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