Results 41 to 50 of about 5,116,336 (302)

Cellular maintenance of nuclear protein homeostasis [PDF]

Cellular and Molecular Life Sciences, 2013
The accumulation and aggregation of misfolded proteins is the primary hallmark for more than 45 human degenerative diseases. These devastating disorders include Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis. Over 15 degenerative diseases are associated with the aggregation of misfolded proteins specifically in the nucleus of
Pamela S. Gallagher, Michelle L. Oeser, Ayelet-chen Abraham, Daniel Kaganovich, Richard G. Gardner   +4 more
openaire   +2 more sources

A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation. [PDF]

, 2010
E-cadherin is a major component of adherens junctions. Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed intestinal homeostasis and barrier function.
Trülzsch, Konrad, Eckhard Wolf, Sylvia Steininger, Hirschi Benjamin, Müller-Höcker Josef, Frank T Kolligs, Allgäuer, Michael, Marlon R. Schneider, Schneider Marlon R., Dahlhoff, Maik, Gerhard Markus, Schneider, Marlon R., Konrad Trülzsch, Vogelmann, Roger, Maik Dahlhoff, Müller-Höcker, Josef, Michael Allgäuer, Allgäuer Michael, Horst David, Roger Vogelmann, Markus Gerhard, Horst, David, Frank T. Kolligs, Wolf Eckhard, Dahlhoff Maik, Benjamin Hirschi, Kolligs, Frank T., David Horst, Trülzsch Konrad, Wolf, Eckhard, Josef Müller-Höcker, Kolligs Frank T., Marlon R Schneider, Hirschi, Benjamin, Steininger Sylvia, Gerhard, Markus, Steininger, Sylvia, Vogelmann Roger   +37 more
core   +1 more source

Protein Homeostasis at the Plasma Membrane

Physiology, 2014
The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving
Pirjo M, Apaja, Gergely L, Lukacs
openaire   +3 more sources

Protein homeostasis networks in physiology and disease [PDF]

Current Opinion in Cell Biology, 2011
Although most text books of biochemistry describe the process of protein folding to a three dimensional native state as an intrinsic property of the primary sequence, it is becoming increasingly clear that this process can go wrong in an almost infinite number of ways.
Hetz Flores, Claudio, Glimcher, Laurie H.   +1 more
openaire   +5 more sources

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System

Cell Reports, 2016
Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration.
John D. Murdoch, Christine M. Rostosky, Sindhuja Gowrisankaran, Amandeep S. Arora, Sandra-Fausia Soukup, Ramon Vidal, Vincenzo Capece, Siona Freytag, Andre Fischer, Patrik Verstreken, Stefan Bonn, Nuno Raimundo, Ira Milosevic   +12 more
doaj   +1 more source

Low-carbohydrate diets affect energy balance and fuel homeostasis differentially in lean and obese rats [PDF]

, 2006
In parallel with increased prevalence of overweight people in affluent societies are individuals trying to lose weight, often using low-carbohydrate diets.
van Dijk, G., Dijk, G. van,, Morens, C., Morens, C.,, Scheurink, A.J.W.,, G. van Dijk, C. Morens, Sirot, V.,, Scheurink, A. J. W., V. Sirot, A. J. W. Scheurink, van Dijk, G.; id_orcid, Sirot, V.   +12 more
core   +2 more sources

Aneuploidy: implications for protein homeostasis and disease [PDF]

Disease Models & Mechanisms, 2014
It has long been appreciated that aneuploidy – in which cells possess a karyotype that is not a multiple of the haploid complement – has a substantial impact on human health, but its effects at the subcellular level have only recently become a focus of investigation.
Oromendia, Ana Belen, Amon, Angelika B
openaire   +5 more sources

Extracellular matrix fragmentation in young, healthy cartilaginous tissues [PDF]

European Cells & Materials, 2018
Although the composition and structure of cartilaginous tissues is complex, collagen II fibrils and aggrecan are the most abundant assemblies in both articular cartilage (AC) and the nucleus pulposus (NP) of the intervertebral disc (IVD).
RJ Craddock, NW Hodson, M Ozols, T Shearer, JA Hoyland, MJ Sherratt   +5 more
doaj   +1 more source

Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease

Cell Reports, 2016
The balance between protein synthesis and protein breakdown is a major determinant of protein homeostasis, and loss of protein homeostasis is one of the hallmarks of aging.
Marieke Visscher, Sasha De Henau, Mattheus H.E. Wildschut, Robert M. van Es, Ineke Dhondt, Helen Michels, Patrick Kemmeren, Ellen A. Nollen, Bart P. Braeckman, Boudewijn M.T. Burgering, Harmjan R. Vos, Tobias B. Dansen   +11 more
doaj   +1 more source

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis [PDF]

, 2012
Peer ...
Welch, A, Robert Judson (279511), Mirela Delibegović, Louise Grant (181930), Grant Louise, Emma K Lees, Judson, R, Andy Welch (181948), Göransson, Olga, Goransson, O, Barbara B Kahn, George D. Mcilroy (181939), Carl Owen (181917), Mcilroy George D., Kendra K. Bence (149032), Olga Göransson, Mody Nimesh, Benjamin G. Neel (162598), Lees, Emma K, Kahn Barbara B., Louise Grant, Nimesh Mody (181963), Bence, Kendra K., Neel Benjamin G., Bence, KK, Grant, L, Owen, C, Mody, Nimesh, Mcilroy, George D, Neel, BG, Owen, Carl, Welch Andy, Olga Göransson (181943), Agouni, Abdelali, Neel, Benjamin G, Abdelali Agouni, Czopek Alicja, Kahn, Barbara B, Neel, Benjamin G., Bence Kendra K., Agouni, A, Lees, Emma K., McIlroy, George, Bence, Kendra K, Abdelali Agouni (181926), Nimesh Mody, Göransson Olga, Lund University., Judson, Robert, Czopek, Alicja, Mody, N, Czopek, A, Kendra K Bence, Mirela Delibegović (181968), Andy Welch, George D Mcilroy, Alicja Czopek (181921), Grant, Louise, Lees, EK, Benjamin G. Neel, Barbara B. Kahn, Delibegovic, Mirela, Barbara B. Kahn (181955), Agouni Abdelali, Kahn, Barbara B., Judson Robert, Göransson, Olga,, Mcilroy, GD, Welch, Andy, Emma K. Lees (181936), Lees Emma K., Robert Judson, Benjamin G Neel, Delibegovic, M, Kendra K. Bence, Delibegović Mirela, Carl Owen, Owen Carl, Mcilroy, George D., Emma K. Lees, Alicja Czopek, Kahn, BB, George D. Mcilroy, Mcilory, GD   +83 more
core   +2 more sources