Results 41 to 50 of about 1,575,616 (301)

Role of Myotonic Dystrophy Protein Kinase [DMPK] in Glucose Homeostasis and Muscle Insulin Action [PDF]

, 2007
Myotonic dystrophy 1 (DM1) is caused by a CTG expansion in the 3′-unstranslated region of the DMPK gene, which encodes a serine/threonine protein kinase. One of the common clinical features of DM1 patients is insulin resistance, which has been associated
Liesa Marc, Ciaraldi, Theodore P, Martí, Luc, Ciaraldi, Theodore P., Palacin, Manuel, Catalucci, Daniele, Wolfgang H Dillmann, Esther Llagostera, Perla Kaliman, Catalucci Daniele, Camps, Marta, Reddy, Sita, Gomis, Ramon, 1946-, Luc Marti, Llagostera Martín, Esther, Antonio Zorzano, Ciaraldi Theodore P., Dillmann, Wolfgang H, Llagostera Esther, Gomis Ramon, Reddy Sita, Camps Marta, Dillmann, Wolfgang H., Kaliman Perla, Sita Reddy, Kaliman, Perla, Ruiz-Lozano Pilar, Llagostera, Esther, Richard Kondo, Ruiz-Lozano, Pilar, Zorzano Olarte, Antonio, Manuel Palacin, Zorzano Antonio, Kondo, Richard, Palacín Prieto, Manuel, Ramon Gomis, Daniele Catalucci, Liesa Torre-Marín, Montserrat, Dillmann Wolfgang H., Marti Luc, Camps Camprubí, Marta, Zorzano, Antonio, Marta Camps, Pilar Ruiz-Lozano, Liesa, Marc, Kondo Richard, Gomis, Ramon, Marc Liesa, Theodore P Ciaraldi, Palacin Manuel   +49 more
core   +1 more source

Loss of Sec-1 Family Domain-Containing 1 (scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish

Journal of Cardiovascular Development and Disease, 2023
Dilated cardiomyopathy (DCM) is a common heart muscle disorder that frequently leads to heart failure, arrhythmias, and death. While DCM is often heritable, disease-causing mutations are identified in only ~30% of cases.
Inken G. Huttner, Celine F. Santiago, Arie Jacoby, Delfine Cheng, Gunjan Trivedi, Stephen Cull, Jasmina Cvetkovska, Renee Chand, Joachim Berger, Peter D. Currie, Kelly A. Smith, Diane Fatkin   +11 more
doaj   +1 more source

Protein homeostasis networks in physiology and disease [PDF]

Current Opinion in Cell Biology, 2011
Although most text books of biochemistry describe the process of protein folding to a three dimensional native state as an intrinsic property of the primary sequence, it is becoming increasingly clear that this process can go wrong in an almost infinite number of ways.
Hetz Flores, Claudio, Glimcher, Laurie H.   +1 more
openaire   +5 more sources

Protein Homeostasis at the Plasma Membrane

Physiology, 2014
The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving
Pirjo M, Apaja, Gergely L, Lukacs
openaire   +3 more sources

Protein Homeostasis, Aging and Alzheimer’s Disease [PDF]

Molecular Neurobiology, 2012
Alzheimer's disease (AD) is one key medical challenge of the aging society and despite a great amount of effort and a huge collection of acquired data on molecular mechanisms that are associated with the onset and progression of this devastating disorder, no causal therapy is in sight.
Morawe, Tobias, Hiebel, Christof, Kern, Andreas, Behl, Christian   +3 more
openaire   +2 more sources

Evaluation of Translation Rate Through L-azidohomoalanine (AHA) Incorporation and Subsequent Alkyne Fluorophore–Mediated Click Chemistry in Yeast

Bio-Protocol
Accurate measurement of protein translation rates is crucial for understanding cellular processes and disease mechanisms. However, existing methods for quantifying translation rates in yeast cells are limited.
Mainak Jha, Koyeli Mapa
doaj   +1 more source

Hepatocyte-specific deletion of peroxisomal protein PEX13 results in disrupted iron homeostasis

, 2020
Peroxisomes are organelles, abundant in the liver, involved in a variety of cellular functions, including fatty acid metabolism, plasmalogen synthesis and metabolism of reactive oxygen species.
Secondes, Eriza S., Subramaniam, V. Nathan, Melino, Michelle, Crane, Denis, Subramaniam, V Nathan, Secondes, Eriza S, Bhatia, Maneet, Rishi, Gautam   +7 more
core   +1 more source

Regulation of Age-Related Protein Toxicity

Frontiers in Cell and Developmental Biology, 2021
Proteome damage plays a major role in aging and age-related neurodegenerative diseases. Under healthy conditions, molecular quality control mechanisms prevent toxic protein misfolding and aggregation.
Anita Pras, Ellen A. A. Nollen
doaj   +1 more source

Protein folding, protein homeostasis, and cancer [PDF]

Chinese Journal of Cancer, 2011
Proteins fold into their functional 3-dimensional structures from a linear amino acid sequence. In vitro this process is spontaneous; while in vivo it is orchestrated by a specialized set of proteins, called chaperones. Protein folding is an ongoing cellular process, as cellular proteins constantly undergo synthesis and degradation. Here emerging links
openaire   +2 more sources

Aneuploidy: implications for protein homeostasis and disease [PDF]

Disease Models & Mechanisms, 2014
It has long been appreciated that aneuploidy – in which cells possess a karyotype that is not a multiple of the haploid complement – has a substantial impact on human health, but its effects at the subcellular level have only recently become a focus of investigation.
Oromendia, Ana Belen, Amon, Angelika B
openaire   +5 more sources