Results 21 to 30 of about 5,116,336 (302)
Frontiers in Microbiology, 2023 The protein homeostasis network ensures a proper balance between synthesis, folding, and degradation of all cellular proteins. DnaK and trigger factor (TF) are ubiquitous bacterial molecular chaperones that assist in protein folding, as well as ...
Judith Matavacas +2 more
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Protein homeostasis and aging in neurodegeneration [PDF]
The Journal of Experimental Medicine, 2010 Genetic and environmental factors responsible for numerous neurodegenerative diseases vary between disorders, yet age remains a universal risk factor. Age-associated decline in protein homeostasis, or proteostasis, enables disease-linked proteins to adopt aberrant tertiary structures, accumulate as higher-ordered aggregates, and cause a myriad of ...
Douglas, Peter M., Dillin, Andrew
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Advanced Science, 2021 Histone acetylation is a key histone post‐translational modification that shapes chromatin structure, dynamics, and function. Bromodomain (BRD) proteins, the readers of acetyl‐lysines, are located in the center of the histone acetylation‐signaling ...
Haoyang Peng +13 more
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Bacterial Protein Homeostasis Disruption as a Therapeutic Intervention
Frontiers in Molecular Biosciences, 2021 Cells have evolved a complex molecular network, collectively called the protein homeostasis (proteostasis) network, to produce and maintain proteins in the appropriate conformation, concentration and subcellular localization.
Laleh Khodaparast +11 more
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Protein homeostasis and synaptic plasticity [PDF]
The EMBO Journal, 2010 It is clear that de novo protein synthesis has an important function in synaptic transmission and plasticity. A substantial amount of work has shown that mRNA translation in the hippocampus is spatially controlled and that dendritic protein synthesis is required for different forms of long-term synaptic plasticity.
Cajigas, I., Will, T., Schuman, E.
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CRYPTOCHROMES promote daily protein homeostasis [PDF]
The EMBO Journal, 2021 The daily organisation of most mammalian cellular functions is attributed to circadian regulation of clock-controlled protein expression, driven by daily cycles of CRYPTOCHROME-dependent transcriptional feedback repression. To test this, we used quantitative mass spectrometry to compare wild-type and CRY-deficient fibroblasts under constant conditions.
Wong, David CS +12 more
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Autophagy Impairment in App Knock-in Alzheimer’s Model Mice
Frontiers in Aging Neuroscience, 2022 Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-β peptide (Aβ) amyloidosis. Amyloid precursor protein (APP) knock-in mice exhibit robust Aβ pathology, providing possibilities to determine its effect on protein
Richeng Jiang +10 more
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Research progress of integrated stress response in pathogenesis of Alzheimer's disease
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Integrated stress response (ISR) is a cellular adaptive response induced by stress, which is strictly regulated by multiple phosphokinases, phosphatases and other proteins to maintain protein homeostasis.
SUN Hui +6 more
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Potential roles for mitochondria-to-HSF1 signaling in health and disease
Frontiers in Molecular Biosciences, 2023 The ability to respond rapidly and efficiently to protein misfolding is crucial for development, reproduction and long-term health. Cells respond to imbalances in cytosolic/nuclear protein homeostasis through the Heat Shock Response, a tightly regulated ...
Johnathan Labbadia
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Mitochondrial Impairment in Sarcopenia
Biology, 2021 Sarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis. During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered
Francesco Bellanti +2 more
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