Results 21 to 30 of about 5,395,698 (297)

Mitochondrial Impairment in Sarcopenia

Biology, 2021
Sarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis. During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered
Francesco Bellanti, Aurelio Lo Buglio, Gianluigi Vendemiale   +2 more
doaj   +1 more source

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons [PDF]

, 2007
Hypothalamic AMP-activated protein kinase (AMPK) has been suggested to act as a key sensing mechanism, responding to hormones and nutrients in the regulation of energy homeostasis.
Carling, D., Choudhury, Agharul I., Smith, Mark A., Fryer, L.G.D., Speakman, J.R., Ashford, MLJ, Carling, D, Withers, DJ, Selman, Colin, Xu, Allison W., Al-Qassab, H, Fryer, Lee G.D., Vaulont, Sophie, Choudhury, AI, Fryer, LGD, Vaulont, S., Claret, Marc, Heffron, H, Speakman, John R., Heffron, H., Barsh, Gregory S., Clements, M, Choudhury, A.I., Vaulont, S, Heffron, Helen, Xu, A.W., Withers, D.J., Viollet, B, Smith, MA, Barsh, G.S., Clements, Melanie, Withers, Dominic J., Viollet, B., Ashford, Michael L. J.; id_orcid, Batterham, RL, Selman, C, Claret, M., Barsh, GS, Claret, M, Selman, C., Al-Qassab, H., Xu, AW, Al-Qassab, Hind, Viollet, Benoit, Smith, M.A., Ashford, M.L.J., Batterham, R.L., Batterham, Rachel L., Carling, David, Speakman, JR, Clements, M.   +50 more
core   +1 more source

Disruption of embryonic blood-CSF barrier in chick embryos reveals the actual importance of this barrier to control E-CSF composition and homeostasis in early brain development [PDF]

, 2013
In vertebrates, early brain development takes place at the expanded anterior end of the neural tube. After closure of the anterior neuropore, the brain wall forms a physiologically sealed cavity that encloses embryonic cerebrospinal fluid (E-CSF), a ...
Bueno i Torrens, David, 1965-, Parvas, Maryam   +1 more
core   +4 more sources

Mining genomes of marine cyanobacteria for elements of zinc homeostasis [PDF]

, 2012
Zinc is a recognized essential element for the majority of organisms, and is indispensable for the correct function of hundreds of enzymes and thousands of regulatory proteins.
Schmid, Ralf, A. Millard (3584540), Ksibe, Amira Z., Andrew eMillard, James P. Barnett, Amira Z. Ksibe, D. J. Scanlan (7640840), A. Z. Ksibe (7640837), David J. Scanlan, Amira eKsibe, J. P. Barnett (7640834), Barnett, James P., Ralf eSchmid, Scanlan, David J., James P. Barnett, Millard, Andrew D., Blindauer, Claudia A., James P Barnett, R. Schmid (7606553), C. A. Blindauer (7640843), Claudia Andrea Blindauer, Andrew Millard, David J Scanlan, Ralf Schmid   +23 more
core   +1 more source

Update on the Protein Homeostasis Network in Bacillus subtilis

, 2022
Protein homeostasis is fundamental to cell function and survival. It relies on an interconnected network of processes involving protein synthesis, folding, post-translational modification and degradation as well as regulators of these processes.
von Wachenfeldt, Claes, Matavacas, Judith, von Wachenfeldt, Claes,, Judith Matavacas, Matavacas, Judith,, Claes von Wachenfeldt, Lund University.   +6 more
core   +2 more sources

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner [PDF]

, 2014
The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis.
Anja Bremm, Moniz, Sonia, David Komander, Bremm, Anja, Komander, David, Sonia Rocha, Mader, Julia, Rocha, Sonia, Sonia Moniz, Julia Mader   +9 more
core   +1 more source

Drosophila TRPM channel is essential for the control of extracellular magnesium levels [PDF]

, 2010
The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the Drosophila TRPM subfamily is
Vladimir Chubanov, Craig Montell, Chen, Xiaodi, Xiaodi Chen, Anna S Dietz, Dietz, Anna S., Anna S. Dietz, Chubanov, Vladimir, Thomas Hofmann, Thomas Gudermann, Chen Xiaodi, Hofmann Thomas, Chubanov Vladimir, Dietz Anna S., Montell Craig, Gudermann, Thomas, Gudermann Thomas, Montell, Craig, Hofmann, Thomas   +18 more
core   +2 more sources

Lipin proteins and metabolic homeostasis

Journal of Lipid Research, 2009
The lipin protein family, consisting of three members, was first identified early this century. In the last few years, the lipin proteins have been shown to have important roles in glycerolipid biosynthesis and gene regulation, and mutations in the corresponding genes cause lipodystrophy, myoglobinuria, and inflammatory disorders.
Karen Reue, Jennifer R. Dwyer
openaire   +3 more sources

α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast

Cells, 2021
Parkinson’s disease (PD) is the most prevalent movement disorder characterized with loss of dopaminergic neurons in the brain. One of the pathological hallmarks of the disease is accumulation of aggregated α-synuclein (αSyn) in cytoplasmic Lewy body ...
Blagovesta Popova, Dajana Galka, Nicola Häffner, Dan Wang, Kerstin Schmitt, Oliver Valerius, Michael Knop, Gerhard H. Braus   +7 more
doaj   +1 more source

Correction to: Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life [PDF]

, 2021
Correction to: "Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in ...
Jiménez, Jessica A., Tuttle, Alex H., Moy, Sheryl S., Zylka, Mark J., Schmid, Ralf S., Ptacek, Travis S., Simon, Jeremy M.   +6 more
core   +1 more source