Results 21 to 30 of about 1,575,616 (301)

Protein homeostasis and aging in neurodegeneration [PDF]

The Journal of Experimental Medicine, 2010
Genetic and environmental factors responsible for numerous neurodegenerative diseases vary between disorders, yet age remains a universal risk factor. Age-associated decline in protein homeostasis, or proteostasis, enables disease-linked proteins to adopt aberrant tertiary structures, accumulate as higher-ordered aggregates, and cause a myriad of ...
Douglas, Peter M., Dillin, Andrew
openaire   +2 more sources

Potential roles for mitochondria-to-HSF1 signaling in health and disease

Frontiers in Molecular Biosciences, 2023
The ability to respond rapidly and efficiently to protein misfolding is crucial for development, reproduction and long-term health. Cells respond to imbalances in cytosolic/nuclear protein homeostasis through the Heat Shock Response, a tightly regulated ...
Johnathan Labbadia
doaj   +1 more source

Mitochondrial Impairment in Sarcopenia

Biology, 2021
Sarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis. During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered
Francesco Bellanti, Aurelio Lo Buglio, Gianluigi Vendemiale   +2 more
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CRYPTOCHROMES promote daily protein homeostasis [PDF]

The EMBO Journal, 2021
The daily organisation of most mammalian cellular functions is attributed to circadian regulation of clock-controlled protein expression, driven by daily cycles of CRYPTOCHROME-dependent transcriptional feedback repression. To test this, we used quantitative mass spectrometry to compare wild-type and CRY-deficient fibroblasts under constant conditions.
Wong, David CS, Seinkmane, Estere, Zeng, Aiwei, Stangherlin, Alessandra, Rzechorzek, Nina M, Beale, Andrew D, Day, Jason, Reed, Martin, Peak-Chew, Sew Y, Styles, Christine T, Edgar, Rachel S, Putker, Marrit, O'Neill, John S   +12 more
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AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons [PDF]

, 2007
Hypothalamic AMP-activated protein kinase (AMPK) has been suggested to act as a key sensing mechanism, responding to hormones and nutrients in the regulation of energy homeostasis.
Carling, D., Choudhury, Agharul I., Smith, Mark A., Fryer, L.G.D., Speakman, J.R., Ashford, MLJ, Carling, D, Withers, DJ, Selman, Colin, Xu, Allison W., Al-Qassab, H, Fryer, Lee G.D., Vaulont, Sophie, Choudhury, AI, Fryer, LGD, Vaulont, S., Claret, Marc, Heffron, H, Speakman, John R., Heffron, H., Barsh, Gregory S., Clements, M, Choudhury, A.I., Vaulont, S, Heffron, Helen, Xu, A.W., Withers, D.J., Viollet, B, Smith, MA, Barsh, G.S., Clements, Melanie, Withers, Dominic J., Viollet, B., Ashford, Michael L. J.; id_orcid, Batterham, RL, Selman, C, Claret, M., Barsh, GS, Claret, M, Selman, C., Al-Qassab, H., Xu, AW, Al-Qassab, Hind, Viollet, Benoit, Smith, M.A., Ashford, M.L.J., Batterham, R.L., Batterham, Rachel L., Carling, David, Speakman, JR, Clements, M.   +50 more
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Mining genomes of marine cyanobacteria for elements of zinc homeostasis [PDF]

, 2012
Zinc is a recognized essential element for the majority of organisms, and is indispensable for the correct function of hundreds of enzymes and thousands of regulatory proteins.
Schmid, Ralf, A. Millard (3584540), Ksibe, Amira Z., Andrew eMillard, James P. Barnett, Amira Z. Ksibe, D. J. Scanlan (7640840), A. Z. Ksibe (7640837), David J. Scanlan, Amira eKsibe, J. P. Barnett (7640834), Barnett, James P., Ralf eSchmid, Scanlan, David J., James P. Barnett, Millard, Andrew D., Blindauer, Claudia A., James P Barnett, R. Schmid (7606553), C. A. Blindauer (7640843), Claudia Andrea Blindauer, Andrew Millard, David J Scanlan, Ralf Schmid   +23 more
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Impact of moderate dietary protein restriction on glucose homeostasis in a model of oestrogen deficiency. [PDF]

, 2022
The need to consume adequate dietary protein to preserve physical function during ageing is well recognized. However, the effect of protein intakes on glucose metabolism is still intensively debated. During age-related oestrogen withdrawal at the time of
Sacco, Sandra M., Horcajada, Marie-Noelle, Ammann, Patrick, Bouzakri, Karim, Karagounis, Leonidas G, Decaens, Thomas, Offord, Elizabeth A, Fournier, Carole, Karagounis, Leonidas G., Sacco, Sandra M   +9 more
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Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner [PDF]

, 2014
The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis.
Anja Bremm, Moniz, Sonia, David Komander, Bremm, Anja, Komander, David, Sonia Rocha, Mader, Julia, Rocha, Sonia, Sonia Moniz, Julia Mader   +9 more
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α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast

Cells, 2021
Parkinson’s disease (PD) is the most prevalent movement disorder characterized with loss of dopaminergic neurons in the brain. One of the pathological hallmarks of the disease is accumulation of aggregated α-synuclein (αSyn) in cytoplasmic Lewy body ...
Blagovesta Popova, Dajana Galka, Nicola Häffner, Dan Wang, Kerstin Schmitt, Oliver Valerius, Michael Knop, Gerhard H. Braus   +7 more
doaj   +1 more source

Drosophila TRPM channel is essential for the control of extracellular magnesium levels [PDF]

, 2010
The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the Drosophila TRPM subfamily is
Vladimir Chubanov, Craig Montell, Chen, Xiaodi, Xiaodi Chen, Anna S Dietz, Dietz, Anna S., Anna S. Dietz, Chubanov, Vladimir, Thomas Hofmann, Thomas Gudermann, Chen Xiaodi, Hofmann Thomas, Chubanov Vladimir, Dietz Anna S., Montell Craig, Gudermann, Thomas, Gudermann Thomas, Montell, Craig, Hofmann, Thomas   +18 more
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