Research progress of integrated stress response in pathogenesis of Alzheimer's disease
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Integrated stress response (ISR) is a cellular adaptive response induced by stress, which is strictly regulated by multiple phosphokinases, phosphatases and other proteins to maintain protein homeostasis.
SUN Hui +6 more
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Protein homeostasis and aging in neurodegeneration [PDF]
The Journal of Experimental Medicine, 2010 Genetic and environmental factors responsible for numerous neurodegenerative diseases vary between disorders, yet age remains a universal risk factor. Age-associated decline in protein homeostasis, or proteostasis, enables disease-linked proteins to adopt aberrant tertiary structures, accumulate as higher-ordered aggregates, and cause a myriad of ...
Douglas, Peter M., Dillin, Andrew
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Potential roles for mitochondria-to-HSF1 signaling in health and disease
Frontiers in Molecular Biosciences, 2023 The ability to respond rapidly and efficiently to protein misfolding is crucial for development, reproduction and long-term health. Cells respond to imbalances in cytosolic/nuclear protein homeostasis through the Heat Shock Response, a tightly regulated ...
Johnathan Labbadia
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Mitochondrial Impairment in Sarcopenia
Biology, 2021 Sarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis. During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered
Francesco Bellanti +2 more
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Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response. [PDF]
, 2019 The progressive failure of protein homeostasis is a hallmark of aging and a common feature in neurodegenerative disease. As the enzymes executing the final stages of autophagy, lysosomal proteases are key contributors to the maintenance of protein ...
Ashrafi, Kaveh +10 more
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Frontiers in Molecular Neuroscience, 2023 Spinocerebellar ataxia type 3 (SCA3), also known as Machado–Joseph disease, is the most common dominantly inherited ataxia. SCA3 is caused by a CAG repeat expansion in the ATXN3 gene that encodes an expanded tract of polyglutamine in the disease protein ...
Haiyang Luo +5 more
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Strategies targeting endoplasmic reticulum stress to improve Parkinson’s disease
Frontiers in Pharmacology, 2023 Parkinson’s disease (PD) is a common neurodegenerative disorder with motor symptoms, which is caused by the progressive death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc).
Danni Wang +6 more
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Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control [PDF]
, 2018 The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7, encoding DJ-1, are associated with early-onset familial Parkinson’s disease and lead to pathological ...
Abeti +66 more
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Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease
Frontiers in Cell and Developmental Biology, 2021 Ubiquitination is a posttranslational modification of proteins that significantly affects protein stability and function. The specificity of substrate recognition is determined by ubiquitin E3 ligase during ubiquitination.
Lidong Wang +3 more
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Selective vulnerability of neurons to acute toxicity after proteasome inhibitor treatment: Implications for oxidative stress and insolubility of newly synthesized proteins [PDF]
, 2010 Maintaining protein homeostasis is vital to cell viability, with numerous studies demonstrating a role for proteasome inhibition occurring during the aging of a variety of tissues and, presumably, contributing to the disruption of cellular homeostasis ...
Dasuri, Kalavathi +7 more
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