Results 11 to 20 of about 5,395,698 (297)
Actin dynamics in protein homeostasis [PDF]
Bioscience Reports, 2022 Cell homeostasis is maintained in all organisms by the constant adjustment of cell constituents and organisation to account for environmental context. Fine-tuning of the optimal balance of proteins for the conditions, or protein homeostasis, is critical ...
Rousseau, Adrien; id_orcid +3 more
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Sorting Nexins in Protein Homeostasis [PDF]
Cells, 2020 Protein homeostasis is maintained by removing misfolded, damaged, or excess proteins and damaged organelles from the cell by three major pathways; the ubiquitin-proteasome system, the autophagy-lysosomal pathway, and the endo-lysosomal pathway.
Katrina F. Cooper, Sara E. Hanley
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Protein homeostasis and synaptic plasticity [PDF]
The EMBO Journal, 2010 It is clear that de novo protein synthesis has an important function in synaptic transmission and plasticity. A substantial amount of work has shown that mRNA translation in the hippocampus is spatially controlled and that dendritic protein synthesis is ...
Iván J Cajigas +5 more
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Organismal Protein Homeostasis Mechanisms [PDF]
Genetics, 2020 Abstract Sustaining a healthy proteome is a lifelong challenge for each individual cell of an organism. However, protein homeostasis or proteostasis is constantly jeopardized since damaged proteins accumulate under proteotoxic stress that originates from ever-changing metabolic, environmental, and pathological conditions. Proteostasis is
Hoppe, Thorsten, Cohen, Ehud
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Mitochondrial protein homeostasis [PDF]
IUBMB Life, 2013 AbstractMitochondria use 800–1,500 proteins to perform their biological functions in the eukaryotic cells. Distinct transport and sorting mechanisms are responsible for the delivery of proteins to the correct location within mitochondria. Mitochondrial proteins undergo processing events and form functional assemblies.
Aksana, Varabyova +2 more
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Protein homeostasis and aging in neurodegeneration [PDF]
The Journal of Experimental Medicine, 2010 Genetic and environmental factors responsible for numerous neurodegenerative diseases vary between disorders, yet age remains a universal risk factor. Age-associated decline in protein homeostasis, or proteostasis, enables disease-linked proteins to adopt aberrant tertiary structures, accumulate as higher-ordered aggregates, and cause a myriad of ...
Douglas, Peter M., Dillin, Andrew
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Mitochondrial Protein Homeostasis and Cardiomyopathy
International Journal of Molecular Sciences, 2022 Human mitochondrial disorders impact tissues with high energetic demands and can be associated with cardiac muscle disease (cardiomyopathy) and early mortality. However, the mechanistic link between mitochondrial disease and the development of cardiomyopathy is frequently unclear.
Emily Wachoski-Dark +4 more
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Protein homeostasis in aging and cancer
Frontiers in Cell and Developmental Biology, 2023 Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can improve health and quality of life for older individuals ...
Xiao-Qiong Chen +5 more
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Potential roles for mitochondria-to-HSF1 signaling in health and disease
Frontiers in Molecular Biosciences, 2023 The ability to respond rapidly and efficiently to protein misfolding is crucial for development, reproduction and long-term health. Cells respond to imbalances in cytosolic/nuclear protein homeostasis through the Heat Shock Response, a tightly regulated ...
Johnathan Labbadia
doaj +1 more source
CRYPTOCHROMES promote daily protein homeostasis [PDF]
The EMBO Journal, 2021 The daily organisation of most mammalian cellular functions is attributed to circadian regulation of clock-controlled protein expression, driven by daily cycles of CRYPTOCHROME-dependent transcriptional feedback repression. To test this, we used quantitative mass spectrometry to compare wild-type and CRY-deficient fibroblasts under constant conditions.
Wong, David CS +12 more
openaire +5 more sources