Results 11 to 20 of about 1,938,673 (304)

METTL3 regulates WTAP protein homeostasis [PDF]

Cell Death & Disease, 2018
The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Capuano, Ernestina, Cruciani, Sonia, Fatica, Alessandro, Fazi, Francesco, Ginistrelli, Lavinia Ceci, Ianniello, Zaira, Larivera, Simone, Marchioni, Marcella, Sorci, Melissa   +8 more
core   +6 more sources

Sorting Nexins in Protein Homeostasis [PDF]

Cells, 2020
Sorting nexins (SNXs) are a highly conserved membrane-associated protein family that plays a role in regulating protein homeostasis. This family of proteins is unified by their characteristic phox (PX) phosphoinositides binding domain. Along with binding to membranes, this family of SNXs also comprises a diverse array of protein-protein interaction ...
Cooper, Katrina F., Hanley, Sarah E.
openaire   +3 more sources

Protein homeostasis in aging and cancer. [PDF]

Front Cell Dev Biol, 2023
Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can improve health and quality of life for older individuals ...
Chen XQ, Shen T, Fang SJ, Sun XM, Li GY, Li YF.   +5 more
europepmc   +4 more sources

Organismal Protein Homeostasis Mechanisms [PDF]

Genetics, 2020
Abstract Sustaining a healthy proteome is a lifelong challenge for each individual cell of an organism. However, protein homeostasis or proteostasis is constantly jeopardized since damaged proteins accumulate under proteotoxic stress that originates from ever-changing metabolic, environmental, and pathological conditions. Proteostasis is
Hoppe, Thorsten, Cohen, Ehud
openaire   +2 more sources

Mitochondrial protein homeostasis [PDF]

IUBMB Life, 2013
AbstractMitochondria use 800–1,500 proteins to perform their biological functions in the eukaryotic cells. Distinct transport and sorting mechanisms are responsible for the delivery of proteins to the correct location within mitochondria. Mitochondrial proteins undergo processing events and form functional assemblies.
Aksana, Varabyova, Diana, Stojanovski, Agnieszka, Chacinska   +2 more
openaire   +2 more sources

Yeast Bromodomain Factor 1 and Its Human Homolog TAF1 Play Conserved Roles in Promoting Homologous Recombination

Advanced Science, 2021
Histone acetylation is a key histone post‐translational modification that shapes chromatin structure, dynamics, and function. Bromodomain (BRD) proteins, the readers of acetyl‐lysines, are located in the center of the histone acetylation‐signaling ...
Haoyang Peng, Simin Zhang, Yihan Peng, Shuangyi Zhu, Xin Zhao, Xiaocong Zhao, Shuangshuang Yang, Guangxue Liu, Yang Dong, Xiaoli Gan, Qing Li, Xinghua Zhang, Huadong Pei, Xuefeng Chen   +13 more
doaj   +1 more source

Bacterial Protein Homeostasis Disruption as a Therapeutic Intervention

Frontiers in Molecular Biosciences, 2021
Cells have evolved a complex molecular network, collectively called the protein homeostasis (proteostasis) network, to produce and maintain proteins in the appropriate conformation, concentration and subcellular localization.
Laleh Khodaparast, Laleh Khodaparast, Guiqin Wu, Guiqin Wu, Ladan Khodaparast, Ladan Khodaparast, Béla Z. Schmidt, Béla Z. Schmidt, Frederic Rousseau, Frederic Rousseau, Joost Schymkowitz, Joost Schymkowitz   +11 more
doaj   +1 more source

Protein homeostasis and synaptic plasticity [PDF]

The EMBO Journal, 2010
It is clear that de novo protein synthesis has an important function in synaptic transmission and plasticity. A substantial amount of work has shown that mRNA translation in the hippocampus is spatially controlled and that dendritic protein synthesis is required for different forms of long-term synaptic plasticity.
Cajigas, I., Will, T., Schuman, E.
openaire   +3 more sources

Actin dynamics in protein homeostasis

Bioscience Reports, 2022
Abstract Cell homeostasis is maintained in all organisms by the constant adjustment of cell constituents and organisation to account for environmental context. Fine-tuning of the optimal balance of proteins for the conditions, or protein homeostasis, is critical to maintaining cell homeostasis.
Thomas D. Williams, Adrien Rousseau
openaire   +3 more sources

Autophagy Impairment in App Knock-in Alzheimer’s Model Mice

Frontiers in Aging Neuroscience, 2022
Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-β peptide (Aβ) amyloidosis. Amyloid precursor protein (APP) knock-in mice exhibit robust Aβ pathology, providing possibilities to determine its effect on protein
Richeng Jiang, Richeng Jiang, Makoto Shimozawa, Johanna Mayer, Simone Tambaro, Rakesh Kumar, Axel Abelein, Bengt Winblad, Bengt Winblad, Nenad Bogdanovic, Per Nilsson   +10 more
doaj   +1 more source