Results 11 to 20 of about 5,116,336 (302)
On the Role of the Immunoproteasome in Protein Homeostasis [PDF]
Cells, 2021 Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation.
Michael Basler, Marcus Groettrup
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Actin dynamics in protein homeostasis [PDF]
Bioscience Reports, 2022 Cell homeostasis is maintained in all organisms by the constant adjustment of cell constituents and organisation to account for environmental context. Fine-tuning of the optimal balance of proteins for the conditions, or protein homeostasis, is critical ...
Rousseau, Adrien; id_orcid +3 more
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pSTAT3 transactivates EGFR in maintaining EGFR protein homeostasis and EGFR-TKI resistance [PDF]
Acta Biochimica et Biophysica SinicaEGFR protein trafficking is critical for regulating multiple biological processes, including cell growth and survival. However, how EGFR protein homeostasis is maintained remains unclear.
Ao Juan +10 more
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Organismal Protein Homeostasis Mechanisms [PDF]
Genetics, 2020 Abstract Sustaining a healthy proteome is a lifelong challenge for each individual cell of an organism. However, protein homeostasis or proteostasis is constantly jeopardized since damaged proteins accumulate under proteotoxic stress that originates from ever-changing metabolic, environmental, and pathological conditions. Proteostasis is
Hoppe, Thorsten, Cohen, Ehud
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Sorting Nexins in Protein Homeostasis [PDF]
Cells, 2020 Sorting nexins (SNXs) are a highly conserved membrane-associated protein family that plays a role in regulating protein homeostasis. This family of proteins is unified by their characteristic phox (PX) phosphoinositides binding domain. Along with binding to membranes, this family of SNXs also comprises a diverse array of protein-protein interaction ...
Sarah E Hanley, Katrina F Cooper
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Mechanisms of Endoplasmic Reticulum Protein Homeostasis in Plants [PDF]
International Journal of Molecular Sciences, 2023 Linchuan Liu +2 more
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Mitochondrial protein homeostasis [PDF]
IUBMB Life, 2013 AbstractMitochondria use 800–1,500 proteins to perform their biological functions in the eukaryotic cells. Distinct transport and sorting mechanisms are responsible for the delivery of proteins to the correct location within mitochondria. Mitochondrial proteins undergo processing events and form functional assemblies.
Aksana, Varabyova +2 more
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Cells, 2022 Ribosomes within a cell are commonly viewed as biochemically homogenous RNA–protein super-complexes performing identical functions of protein synthesis.
Wenzhu Li +6 more
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Targeting of client proteins to the VCP/p97/Cdc48 unfolding machine
Frontiers in Molecular Biosciences, 2023 The AAA+ ATPase p97 (also called VCP or Cdc48) is a major protein unfolding machine with hundreds of clients in diverse cellular pathways that are critical for cell homeostasis, proliferation and signaling. In this review, we summarize recent advances in
Hemmo Meyer, Johannes van den Boom
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Structure of the human marker of self 5-transmembrane receptor CD47
Nature Communications, 2021 CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the ...
Gustavo Fenalti +15 more
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