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The Unfolded Protein Response: An Overview [PDF]
Biology, 2021 The unfolded protein response is the mechanism by which cells control endoplasmic reticulum (ER) protein homeostasis. Under normal conditions, the UPR is not activated; however, under certain stresses, such as hypoxia or altered glycosylation, the UPR ...
Adam Read, Martin Schröder
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Melanoma and the Unfolded Protein Response [PDF]
Cancers, 2016 The UPR (unfolded protein response) has been identified as a key factor in the progression and metastasis of cancers, notably melanoma. Several mediators of the UPR are upregulated in cancers, e.g., high levels of GRP78 (glucose-regulator protein 78 kDa) correlate with progression and poor outcome in melanoma patients.
Erin Sykes, Richard I Christopherson
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The Unfolded Protein Response and Diabetic Retinopathy [PDF]
Journal of Diabetes Research, 2014 Diabetic retinopathy, a common complication of diabetes, is the leading cause of blindness in adults. Diabetes chronically damages retinal blood vessels and neurons likely through multiple pathogenic pathways such as oxidative stress, inflammation, and endoplasmic reticulum (ER) stress.
Jacey Hongjie Ma +2 more
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New twists in the unfolded protein response
eLife, 2012 The response of S. pombe, also known as fission yeast, to misfolded proteins involves mechanisms that have not been observed in other species.
Benedict C S Cross, David Ron
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The endoplasmic reticulum and the unfolded protein response [PDF]
Seminars in Cell and Developmental Biology, 2007 The endoplasmic reticulum (ER) is the site where proteins enter the secretory pathway. Proteins are translocated into the ER lumen in an unfolded state and require protein chaperones and catalysts of protein folding to attain their final appropriate conformation.
Randal Kaufman
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Cell ReportsSummary: Despite the consensus that accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen, i.e. ER stress, activates the unfolded protein response (UPR), studies under physiological and pathophysiological conditions suggest that ER ...
Fenfen Xu, Likun Wang
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Frontiers in Molecular Neuroscience, 2022 Aging and age-related neurodegeneration are both associated with the accumulation of unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis (termed proteostasis) in maintaining organismal health.
Andrew P. K. Wodrich +7 more
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