Results 1 to 10 of about 1,131,301 (162)

The Unfolded Protein Response: An Overview

Biology, 2021
The unfolded protein response is the mechanism by which cells control endoplasmic reticulum (ER) protein homeostasis. Under normal conditions, the UPR is not activated; however, under certain stresses, such as hypoxia or altered glycosylation, the UPR ...
Adam Read, Martin Schröder
doaj   +2 more sources

Unfolded protein response in colorectal cancer

Cell & Bioscience, 2021
Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or the rectum. A growing number of researches prove that the unfolded protein response (UPR) is closely related to the occurrence and progression of colorectal ...
Jingjing Huang, Huayang Pan, Jinge Wang, Tong Wang, Xiaoyan Huo, Yong Ma, Zhaoyang Lu, Bei Sun, Hongchi Jiang   +8 more
doaj   +2 more sources

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

Cell, 2016
SUMMARY Functional genomics efforts face tradeoffs between number of perturbations examined and complexity of phenotypes measured. We bridge this gap with Perturb-seq, which combines droplet-based single-cell RNA-seq with a strategy for barcoding CRISPR ...
Britt Adamson, Thomas M Norman, Marco Jost   +2 more
exaly   +2 more sources

Mechanisms, regulation and functions of the unfolded protein response

Nature Reviews Molecular Cell Biology, 2020
Claudio Hetz, Kezhong Zhang, Randal J Kaufman   +2 more
exaly   +2 more sources

Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER

Cell Reports
Summary: Despite the consensus that accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen, i.e. ER stress, activates the unfolded protein response (UPR), studies under physiological and pathophysiological conditions suggest that ER ...
Fenfen Xu, Likun Wang
doaj   +3 more sources

The Unfolded Protein Responses in Health, Aging, and Neurodegeneration: Recent Advances and Future Considerations

Frontiers in Molecular Neuroscience, 2022
Aging and age-related neurodegeneration are both associated with the accumulation of unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis (termed proteostasis) in maintaining organismal health.
Andrew P. K. Wodrich, Andrew P. K. Wodrich, Andrew P. K. Wodrich, Andrew W. Scott, Arvind Kumar Shukla, Brent T. Harris, Brent T. Harris, Edward Giniger   +7 more
doaj   +1 more source

The unfolded protein response protects from tau neurotoxicity in vivo. [PDF]

PLoS ONE, 2010
The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in modulating the effects of aggregation prone cytosolic proteins has received less attention.
Carin A Loewen, Mel B Feany
doaj   +1 more source

Unfolded protein response in rice (Oryza sativa L.) varieties with different level of salt stress tolerance

Indonesian Journal of Biotechnology, 2021
Plants activate the unfolded protein response as part of cellular adaptation, thereby maintaining the endoplasmic reticulum homeostasis during external stresses exposure.
Galang Rizki Ramadhan, Sholeh Avivi, Bambang Sugiharto, Wahyu Indra Duwi Fanata   +3 more
doaj   +1 more source

Reshaping Endoplasmic Reticulum Quality Control Through the Unfolded Protein Response

Molecules and Cells, 2022
SUMMARY Endoplasmic reticulum quality control (ERQC) pathways comprised of chaperones, folding enzymes, and degradation factors ensure the fidelity of ER protein folding and trafficking to downstream secretory environments.
R. Wiseman, Jaleh S. Mesgarzadeh, L. Hendershot   +2 more
semanticscholar   +1 more source

Unfolded protein response in myelin disorders

Neural Regeneration Research, 2020
Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions.
Wensheng Lin, Sarrabeth Stone
doaj   +1 more source