Ferroptosis and endoplasmic reticulum stress in ischemic stroke
Neural Regeneration Research, 2023 Ferroptosis is a form of non-apoptotic programmed cell death, and its mechanisms mainly involve the accumulation of lipid peroxides, imbalance in the amino acid antioxidant system, and disordered iron metabolism.
Yina Li +6 more
doaj +2 more sources
Endoplasmic reticulum stress in lung cancer [PDF]
Frontiers in OncologyEndoplasmic reticulum is the primary site of eukaryotic cells involved in biosynthesis, lipid metabolism, glucose metabolism, protein folding and secretion.
Donghuan Zhang +6 more
doaj +2 more sources
Research progress on the role of endoplasmic reticulum stress in osteoarthritis [PDF]
Jichu yixue yu linchuang, 2023 Osteoarthritis is a common degenerative disease in which endoplasmic reticulum stress(ER stress) plays an important role in the pathogenesis of chondrocyte apoptosis.
JIN Tao, YANG Qingshan, WU Shujin, ZHU Xiaoyan, SHI Yucong, NIU Jianxiong, LIU Lin
doaj +1 more source
Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]
, 2013 We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Condon, Jennifer C. +5 more
core +13 more sources
Protein quality control and aggregation in the endoplasmic reticulum: From basic to bedside
Frontiers in Cell and Developmental Biology, 2023 Endoplasmic reticulum (ER) is the largest membrane-bound compartment in all cells and functions as a key regulator in protein biosynthesis, lipid metabolism, and calcium balance.
Guofang Chen +5 more
doaj +1 more source
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 The endoplasmic reticulum (ER) functions as a quality-control organelle for protein homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated degradation, protein chaperons, and autophagy.
Xingyi Chen +4 more
semanticscholar +1 more source
Reshaping endoplasmic reticulum quality control through the unfolded protein response.
Molecules and Cells, 2022 Endoplasmic reticulum quality control (ERQC) pathways comprising chaperones, folding enzymes, and degradation factors ensure the fidelity of ER protein folding and trafficking to downstream secretory environments.
R. Wiseman +2 more
semanticscholar +1 more source
Endoplasmic Reticulum Stress in Liver Diseases.
Hepatology, 2022 The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding of linear polypeptides and proteins, a process tightly governed by the ER-resident enzymes and chaperones.
Amir Ajoolabady +6 more
semanticscholar +1 more source
Prediction of endoplasmic reticulum resident proteins using fragmented amino acid composition and support vector machine [PDF]
PeerJ, 2017 Background The endoplasmic reticulum plays an important role in many cellular processes, which includes protein synthesis, folding and post-translational processing of newly synthesized proteins.
Ravindra Kumar +2 more
doaj +2 more sources
Antioxidants, 2023 The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if this activation is prolonged ...
Alexis Martinez +16 more
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