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Signal integration in the endoplasmic reticulum unfolded protein response
Nature reviews. Molecular cell biology, 2007D. Ron, P. Walter
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Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Science, 2004U. Özcan +9 more
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1992
Publisher Summary This chapter presents the current understanding of the structural elements that make up endoplasmic reticulum (ER). The primary structural elements of the ER are the molecular components such as the proteins, lipids, and ions. The secondary elements are the local organizational motifs formed by the individual components. In the case
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Publisher Summary This chapter presents the current understanding of the structural elements that make up endoplasmic reticulum (ER). The primary structural elements of the ER are the molecular components such as the proteins, lipids, and ions. The secondary elements are the local organizational motifs formed by the individual components. In the case
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Compartmentation of the rough endoplasmic reticulum
Molecular and Cellular Biochemistry, 1986It has become evident during recent years that a wide variety of proteins are synthesized on membrane-bound polysomes, very many of which are not ultimately secreted from the cell. The majority of proteins appear to go through some form of post-translational modification before the final appearance of an 'active' product, and in some cases the ...
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1989
The endoplasmic reticulum (ER) may form up to half of the cell’s total membrane (table 1.1). This proportion is strikingly high in those cells specialised for the export of lipids (such as hepatocytes and cells of the gonads) or of proteins (such as pancreatic cells or certain classes of B lymphocytes).
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The endoplasmic reticulum (ER) may form up to half of the cell’s total membrane (table 1.1). This proportion is strikingly high in those cells specialised for the export of lipids (such as hepatocytes and cells of the gonads) or of proteins (such as pancreatic cells or certain classes of B lymphocytes).
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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
Nature, 1999H. Harding, Yuhong Zhang, D. Ron
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Endoplasmic Reticulum Stress and Obesity
2017In recent years, the world has seen an alarming increase in obesity and is closely associated with insulin resistance, which is a state of low-grade inflammation, the latter characterized by elevated levels of proinflammatory cytokines in blood and tissues.
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Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum
Nature, 2023Volker Dotsch +2 more
exaly