Results 21 to 30 of about 118,726 (215)

Transmembrane domain length is responsible for the ability of a plant reticulon to shape endoplasmic reticulum tubules in vivo [PDF]

, 2010
Reticulons are integral endoplasmic reticulum (ER) membrane proteins that have the ability to shape the ER into tubules. It has been hypothesized that their unusually long conserved hydrophobic regions cause reticulons to assume a wedge-like topology ...
Eastmond, Peter J., Hawes, Chris, Craddock, Christian P., Peter J. Eastmond, Eastmond, Peter J, Tolley, Nicholas, Hawes, C. R., Frigerio, Lorenzo, John Runions, Craddock, Christian P, Lorenzo Frigerio, Nicholas Tolley, Christian P. Craddock, Chris Hawes, Runions, John, Imogen Sparkes, Sparkes, Imogen   +16 more
core   +1 more source

Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation [PDF]

, 2012
Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately ...
Amanda Denuc, Marfany Gemma, Denuc Isern, Amanda, Burr, A. A., Gemma Marfany, Blount Jessica R., Sokol V Todi, Todi Sokol V., Marfany i Nadal, Gemma, Jessica R Blount, Denuc Amanda, Blount, J. R., Aaron A Burr, Burr Aaron A., Todi, Sokol V.   +14 more
core   +2 more sources

Surveying the floodgates: Estimating protein flux into the endoplasmic reticulum lumen in Saccharomyces cerevisiae

Frontiers in Physiology, 2014
Endoplasmic reticulum resident proteins, along with all proteins traveling through the secretory pathway must enter endoplasmic reticulum lumen through membrane-embedded translocons.
Michael eVincent, Mark eWhidden, Santiago eSchnell, Santiago eSchnell, Santiago eSchnell   +4 more
doaj   +1 more source

Septin-dependent compartmentalization of the endoplasmic reticulum during yeast polarized growth [PDF]

, 2005
Polarized cells frequently use diffusion barriers to separate plasma membrane domains. It is unknown whether diffusion barriers also compartmentalize intracellular organelles.
Cosima Luedeke, Ivo Sbalzarini, Frei, S. B., Sbalzarini, I., Anne Spang, Barral, Y., Spang, A. ; https://orcid.org/, Yves Barral, Luedeke, C., Schwarz, H., Heinz Schwarz, Stéphanie Buvelot Frei, Spang, A., Buvelot Frei, S., Frei SB, Barral Y, Luedeke C, Spang A, Sbalzarini I, Schwarz H   +19 more
core   +1 more source

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]

, 2013
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Estes, M. K., Guix Arnau, Susana, Katayama, K., Crawford, Sue E., Sharp, T. M.   +4 more
core   +3 more sources

The overexpression of nuclear envelope protein Lap2β induces endoplasmic reticulum reorganisation via membrane stacking

Biology Open, 2012
Summary Some nuclear envelope proteins are localised to both the nuclear envelope and the endoplasmic reticulum; therefore, it seems plausible that even small amounts of these proteins can influence the organisation of the endoplasmic reticulum. A simple
Ekaterina G. Volkova, Sergey S. Abramchuk, Eugene V. Sheval   +2 more
doaj   +1 more source

Destroy and exploit: catalyzed removal of hydroperoxides from the endoplasmic reticulum [PDF]

, 2013
Peroxidases are enzymes that reduce hydroperoxide substrates. In many cases, hydroperoxide reduction is coupled to the formation of a disulfide bond, which is transferred onto specific acceptor molecules, the so-called reducing substrates.
Thomas Ramming, Ramming, Thomas, Appenzeller-Herzog, Christian, Christian Appenzeller-Herzog, Ramming T, Appenzeller-Herzog C   +5 more
core   +1 more source

Neuroprotective effects of atorvastatin against cerebral ischemia/reperfusion injury through the inhibition of endoplasmic reticulum stress

Neural Regeneration Research, 2015
Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear.
Jian-wen Yang, Zhi-ping Hu
doaj   +1 more source

Membrane-associated RING ubiquitin ligase RNF-121 and advancement of cancer [PDF]

Cellular, Molecular and Biomedical Reports
Exploration of E3 ubiquitin ligases as potential therapeutic targets has been ongoing for two to three decades. Various chemicals and drugs have been developed to either upregulate or inhibit the activity of E3 ligases, aiming to mitigate several ...
Somesh Roy
doaj   +1 more source

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

Neural Regeneration Research
The endoplasmic reticulum, a key cellular organelle, regulates a wide variety of cellular activities. Endoplasmic reticulum autophagy, one of the quality control systems of the endoplasmic reticulum, plays a pivotal role in maintaining endoplasmic ...
Xiu-Yun Zhao, De-En Xu, Ming-Lei Wu, Ji-Chuan Liu, Zi-Ling Shi, Quan-Hong Ma   +5 more
doaj   +1 more source