Results 21 to 30 of about 636,928 (251)
Endoplasmic Reticulum Stress in Liver Diseases
Hepatology, 2022 The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding of linear polypeptides and proteins, a process tightly governed by the ER-resident enzymes and chaperones.
Amir Ajoolabady +6 more
semanticscholar +1 more source
Prediction of endoplasmic reticulum resident proteins using fragmented amino acid composition and support vector machine [PDF]
PeerJ, 2017 Background The endoplasmic reticulum plays an important role in many cellular processes, which includes protein synthesis, folding and post-translational processing of newly synthesized proteins.
Ravindra Kumar +2 more
doaj +2 more sources
Antioxidants, 2023 The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if this activation is prolonged ...
Alexis Martinez +16 more
doaj +1 more source
Trends in Cell Biology, 2022 Calcium ion (Ca2+) is a ubiquitous and versatile signaling molecule controlling a wide variety of cellular processes, such as proliferation, cell death, migration, and immune response, all fundamental processes essential for the establishment of cancer ...
Shanliang Zheng +4 more
semanticscholar +1 more source
Endoplasmic reticulum stress-mediated cell death in liver injury
Cell Death and Disease, 2022 The endoplasmic reticulum is an important intracellular organelle that plays an important role in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) are induced when the body is exposed to adverse ...
Jian Zhang +5 more
semanticscholar +1 more source
Endoplasmic reticulum stress and lipids in health and diseases.
Progress in lipid research, 2022 The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many cellular pathways, including protein synthesis, protein quality control and lipid synthesis. When one or multiple ER roles are dysregulated and saturated, the ER enters
Cenk Celik +3 more
semanticscholar +1 more source
The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling
Experimental and Molecular Medicine, 2021 The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main functions include protein synthesis, proper protein folding, protein modification, and the transportation of synthesized proteins.
K. R. Bhattarai +3 more
semanticscholar +1 more source
Mitochondrial-Endoplasmic Reticulum Communication-Mediated Oxidative Stress and Autophagy
BioMed Research International, 2022 Oxidative stress is an imbalance between free radicals and the antioxidant system causing overgeneration of free radicals (oxygen‐containing molecules) ultimately leading to oxidative damage in terms of lipid peroxidation, protein denaturation, and DNA ...
Xiao-qing Liu +5 more
semanticscholar +1 more source
Endoplasmic Reticulum-Associated Protein Degradation.
Cold Spring Harbor Perspectives in Biology, 2022 Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated degradation (ERAD).
L. Krshnan +2 more
semanticscholar +1 more source
Protein Folding in the Endoplasmic Reticulum [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 In this article, we will cover the folding of proteins in the lumen of the endoplasmic reticulum (ER), including the role of three types of covalent modifications: signal peptide removal, N-linked glycosylation, and disulfide bond formation, as well as the function and importance of resident ER folding factors.
Braakman, I., Hebert, D.N.
openaire +3 more sources