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Endoplasmic Reticulum Stress and Inflammation [PDF]
Digestive Diseases, 2012 Endoplasmic reticulum (ER) stress due to the presence of misfolded or unfolded proteins in the ER invokes a fundamental biological response, termed the unfolded protein response (UPR). The UPR is orchestrated by three main proximal effectors, of which the IRE1/XBP1 pathway represents the evolutionarily most conserved one.
Adolph TE +3 more
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Endoplasmic reticulum stress and apoptosis [PDF]
Cellular and Molecular Biology Letters, 2006 AbstractCell death is an essential event in normal life and development, as well as in the pathophysiological processes that lead to disease. It has become clear that each of the main cellular organelles can participate in cell death signalling pathways, and recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death
Faitova, Jitka +3 more
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Endoplasmic Reticulum Stress and Cancer [PDF]
Journal of Cancer Prevention, 2014 The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular functions including protein folding and maturation and the maintenance of cellular homeostasis. ER stress is activated by a variety of factors and triggers the unfolded protein response (UPR), which restores homeostasis or activates cell death.
Yadav, Raj Kumar +3 more
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ENDOPLASMIC RETICULUM STRESS IN SEPSIS [PDF]
Shock, 2015 Sepsis is an enormous public health issue and the leading cause of death in critically ill patients in intensive care units. Overwhelming inflammation, characterized by cytokine storm, oxidative threats, and neutrophil sequestration, is an underlying component of sepsis-associated organ failure.
Mohammad Moshahid, Khan +2 more
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Endoplasmic reticulum stress and angiogenesis [PDF]
Fiziolohichnyĭ zhurnal, 2013 The endoplasmic reticulum is a dynamic intracellular organelle with exquisite sensitivity to alterations in homeostasis, and provides stringent quality control systems to ensure that the only correctly folded proteins transit to the Golgi and unfolded or misfolded proteins are retained and ultimately degraded.
D O, Minchenko +8 more
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Endoplasmic Reticulum Stress in Malignancy [PDF]
Cancer Cell, 2014 The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival.
Clarke, Hanna J +3 more
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Obesity and endoplasmic reticulum (ER) stresses [PDF]
Frontiers in Immunology, 2012 In obesity, the adipose cells behave as inflammatory source and result to low grade inflammation. This systemic inflammation along with oxidative stress is a silent killer and damages other vital organs also. High metabolic process, induced due to high nutritional intake, results to endoplasmic reticulum (ER) stress and mitochondrial stress.
Tripathi, Yamini B., Pandey, Vivek
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Endoplasmic Reticulum Stress in Bone Metastases [PDF]
Frontiers in Oncology, 2020 Metastases-the spreading of cancer cells from primary tumors to distant organs, including bone-is often incurable and is the major cause of morbidity in cancer patients. Understanding how cancer cells acquire the ability to colonize to bone and become overt metastases is critical to identify new therapeutic targets and develop new therapies against ...
Longyong Xu +11 more
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Endoplasmic reticulum stress and atherosclerosis [PDF]
Nature Medicine, 2010 Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention and treatment, these conditions still account for one third of all deaths annually. Often presented together with obesity, insulin resistance and type 2 diabetes, these chronic diseases are ...
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Endoplasmic reticulum stress in airway hyperresponsiveness
Biomedicine & Pharmacotherapy, 2022 Airway hyperresponsiveness(AHR) is a major clinical phenomenon in lung diseases (asthma, COPD and pulmonary fibrosis) and not only a high-risk factor for perioperative airway spasm leading to hypoxaemia, haemodynamic instability and even "silent lung", but also a potential risk for increased mortality from underlying diseases (e.g.
Qirui, Duan, Ying, Zhou, Dong, Yang
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