Results 11 to 20 of about 2,960,809 (306)

Endoplasmic reticulum stress and diabetic retinopathy

Vascular Health and Risk Management, 2008
Toshiyuki Oshitari1,2, Natsuyo Hata1, Shuichi Yamamoto11Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba City, Chiba, Japan; 2Department of Ophthalmology, Kimitsu Central Hospital, Kisarazu City, Chiba ...
Natsuyo Hata, Toshiyuki Oshitari, Shuichi Yamamoto   +2 more
core   +5 more sources

Endoplasmic reticulum stress in lung cancer

Frontiers in Oncology
Endoplasmic reticulum is the primary site of eukaryotic cells involved in biosynthesis, lipid metabolism, glucose metabolism, protein folding and secretion.
Donghuan Zhang, Lanlan Lin, Hui Jin, Huajun Mao, Luying Wang, Wenwen Ma, Zhenghong Lao   +6 more
doaj   +4 more sources

Endoplasmic reticulum stress in lung disease [PDF]

European Respiratory Review, 2017
Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional ...
Stefan J. Marciniak
doaj   +3 more sources

Endoplasmic Reticulum Stress and Inflammation [PDF]

Digestive Diseases, 2012
Endoplasmic reticulum (ER) stress due to the presence of misfolded or unfolded proteins in the ER invokes a fundamental biological response, termed the unfolded protein response (UPR). The UPR is orchestrated by three main proximal effectors, of which the IRE1/XBP1 pathway represents the evolutionarily most conserved one.
Adolph TE, Niederreiter L, Blumberg RS, Kaser A   +3 more
openaire   +2 more sources

Endoplasmic reticulum stress and angiogenesis [PDF]

Fiziolohichnyĭ zhurnal, 2013
The endoplasmic reticulum is a dynamic intracellular organelle with exquisite sensitivity to alterations in homeostasis, and provides stringent quality control systems to ensure that the only correctly folded proteins transit to the Golgi and unfolded or misfolded proteins are retained and ultimately degraded.
D O, Minchenko, K I, Kubaĭchuk, O V, Hubenia, I V, Kryvdiuk, Ie V, Khomenko, R M, Herasymenko, R V, Sulik, N K, Murashko, O H, Minchenko   +8 more
openaire   +2 more sources

ENDOPLASMIC RETICULUM STRESS IN SEPSIS [PDF]

Shock, 2015
Sepsis is an enormous public health issue and the leading cause of death in critically ill patients in intensive care units. Overwhelming inflammation, characterized by cytokine storm, oxidative threats, and neutrophil sequestration, is an underlying component of sepsis-associated organ failure.
Mohammad Moshahid, Khan, Weng-Lang, Yang, Ping, Wang   +2 more
openaire   +2 more sources

Endoplasmic reticulum stress and apoptosis [PDF]

Cellular and Molecular Biology Letters, 2006
AbstractCell death is an essential event in normal life and development, as well as in the pathophysiological processes that lead to disease. It has become clear that each of the main cellular organelles can participate in cell death signalling pathways, and recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death
Faitova, Jitka, Krekac, Daniel, Hrstka, Roman, Vojtesek, Borivoj   +3 more
openaire   +2 more sources

Endoplasmic Reticulum Stress and Cancer [PDF]

Journal of Cancer Prevention, 2014
The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular functions including protein folding and maturation and the maintenance of cellular homeostasis. ER stress is activated by a variety of factors and triggers the unfolded protein response (UPR), which restores homeostasis or activates cell death.
Yadav, Raj Kumar, Chae, Soo-Wan, Kim, Hyung-Ryong, Chae, Han Jung   +3 more
openaire   +2 more sources

Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes : salicylate alleviates this stress [PDF]

, 2010
Recent findings indicate that endoplasmic reticulum (ER) stress is significantly increased in adipose tissue of obese human subjects and is critical to the initiation and integration of pathways of inflammation and insulin action.
Saif Alhusaini, Harte, A., McGee, K., Gyanendra Tripathi, Kumar, Sudhesh, Tripathi, Gyanendra, Sudhesh Kumar, Alhusaini, S., McTernan, P. G., Harte, A. L., McTernan, P., Bruno Schisano, Philip McTernan, Schisano, B., McGee, K. C., Kumar, S., Alison Harte, Tripathi, G., Kirsty McGee   +18 more
core   +1 more source

Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]

, 2013
We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Subedi, Kalpana, Jennifer C. Condon, Chandrashekara Kyathanahalli, Kalpana Subedi, Lydon, John P., Arvind Suresh, Kyathanahalli, Chandrashekara, Condon, Jennifer C., Jeyasuria, Pancharatnam, Pancharatnam Jeyasuria, Rashekara Kyathanahalli, Jennifer C Condon, Suresh, Arvind   +12 more
core   +2 more sources