Results 31 to 40 of about 207,246 (261)
Endoplasmic reticulum stress in airway hyperresponsiveness
Biomedicine & Pharmacotherapy, 2022 Airway hyperresponsiveness(AHR) is a major clinical phenomenon in lung diseases (asthma, COPD and pulmonary fibrosis) and not only a high-risk factor for perioperative airway spasm leading to hypoxaemia, haemodynamic instability and even "silent lung", but also a potential risk for increased mortality from underlying diseases (e.g.
Qirui, Duan, Ying, Zhou, Dong, Yang
openaire +2 more sources
Frontiers in Physiology, 2023 Introduction: Bronchopulmonary dysplasia (BPD) is a life-threatening lung illness that affects premature infants and has a high incidence and mortality.
Ziyu Tao +9 more
doaj +1 more source
Endoplasmic Reticulum Stress Triggers Autophagy [PDF]
Journal of Biological Chemistry, 2006 Eukaryotic cells have evolved strategies to respond to stress conditions. For example, autophagy in yeast is primarily a response to the stress of nutrient limitation. Autophagy is a catabolic process for the degradation and recycling of cytosolic, long lived, or aggregated proteins and excess or defective organelles.
Tomohiro, Yorimitsu +3 more
openaire +2 more sources
Endoplasmic Reticulum Stress and Ethanol Neurotoxicity [PDF]
Biomolecules, 2015 Ethanol abuse affects virtually all organ systems and the central nervous system (CNS) is particularly vulnerable to excessive ethanol exposure. Ethanol exposure causes profound damages to both the adult and developing brain. Prenatal ethanol exposure induces fetal alcohol spectrum disorders (FASD) which is associated with mental retardation and other ...
Fanmuyi Yang, Jia Luo
openaire +3 more sources
Neural Regeneration Research, 2015 Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear.
Jian-wen Yang, Zhi-ping Hu
doaj +1 more source
BMC Musculoskeletal Disorders, 2023 Background We aimed to establish an osteosarcoma prognosis prediction model based on a signature of endoplasmic reticulum stress-related genes. Methods Differentially expressed genes (DEGs) between osteosarcoma with and without metastasis from The Cancer
Yong Zhao +5 more
doaj +1 more source
Ferroptosis and endoplasmic reticulum stress in ischemic stroke
Neural Regeneration ResearchFerroptosis is a form of non-apoptotic programmed cell death, and its mechanisms mainly involve the accumulation of lipid peroxides, imbalance in the amino acid antioxidant system, and disordered iron metabolism.
Yina Li +6 more
doaj +1 more source
Endoplasmic reticulum stress in diseases
MedCommAbstractThe endoplasmic reticulum (ER) is a key organelle in eukaryotic cells, responsible for a wide range of vital functions, including the modification, folding, and trafficking of proteins, as well as the biosynthesis of lipids and the maintenance of intracellular calcium homeostasis. A variety of factors can disrupt the function of the ER, leading
Yingying Liu +5 more
openaire +3 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Stress, the Endoplasmic Reticulum, and Insulin Resistance
Annals of the New York Academy of Sciences, 2006 Abstract: Stress, such as nutrient deprivation, viral infections, inflammation, heat shock, or lipid accumulation, imposes a serious threat to the body. These stimuli, acting both on the central control stations of the stress system and its final effectors, catecholamines and glucocorticoids, and on the peripheral target tissues, can modulate insulin
Tsiotra, Panayoula C. +1 more
openaire +3 more sources