Obesity and endoplasmic reticulum (ER) stresses [PDF]
Frontiers in Immunology, 2012 In obesity, the adipose cells behave as inflammatory source and result to low grade inflammation. This systemic inflammation along with oxidative stress is a silent killer and damages other vital organs also. High metabolic process, induced due to high nutritional intake, results to endoplasmic reticulum (ER) stress and mitochondrial stress.
Tripathi, Yamini B., Pandey, Vivek
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Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution [PDF]
, 2014 Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR ...
DeMayo, Fransesco J. +26 more
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Travelling to Rome : inflammation, endoplasmic reticulum stress and angiogenesis during atherosclerotic plaque development [PDF]
, 2010 Cardiovascular diseases are the leading cause of death worldwide followed by cancer. Atherosclerosis, the major underlying cause of cardiovascular diseases, is a syndrome affecting medium-sized and large arteries.
Kyriakakis, Emmanouil
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Membrane-associated RING ubiquitin ligase RNF-121 and advancement of cancer [PDF]
Cellular, Molecular and Biomedical ReportsExploration of E3 ubiquitin ligases as potential therapeutic targets has been ongoing for two to three decades. Various chemicals and drugs have been developed to either upregulate or inhibit the activity of E3 ligases, aiming to mitigate several ...
Somesh Roy
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Research progress of endoplasmic reticulum stress of hypoxic pulmonary hypertension [PDF]
Jichu yixue yu linchuang, 2023 Hypoxic pulmonary hypertension (HPH) is a serious complication caused by long-term hypoxia,which is characterized by persistent vasoconstriction and irreversible vascular remodeling.
LIU Xingxing, WANG Weiwei, YUAN Haoxin
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Endoplasmic Reticulum Stress in the Heart [PDF]
Circulation Research, 2007 Over the last decade, it has become clear that the accumulation of misfolded proteins contributes to a number of neurodegenerative, immune, and endocrine pathologies, as well as other age-related illnesses. Recent interest has focused on the possibility that the accumulation of misfolded proteins can also contribute to vascular and cardiac diseases. In
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Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]
, 2011 Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
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IP3R1/GRP75/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling [PDF]
, 2022 Rationale Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are important mechanisms of atrial remodeling, predisposing to the development of atrial fibrillation (AF) in type 2 diabetes mellitus (T2DM).
Tse, G.
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Endoplasmic reticulum stress and atherosclerosis [PDF]
Nature Medicine, 2010 Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention and treatment, these conditions still account for one third of all deaths annually. Often presented together with obesity, insulin resistance and type 2 diabetes, these chronic diseases are ...
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Frontiers in Physiology, 2023 Introduction: Bronchopulmonary dysplasia (BPD) is a life-threatening lung illness that affects premature infants and has a high incidence and mortality.
Ziyu Tao +9 more
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