Results 51 to 60 of about 2,960,809 (306)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Endoplasmic Reticulum Stress in Cancer

MedComm
ABSTRACTPersistent and intense endoplasmic reticulum (ER) stress is widely acknowledged as a hallmark of tumorigenesis. To restore ER homeostasis, cells activate the unfolded protein response (UPR), which is aberrantly regulated in cancer cells.
Ruixin Zhou, Wenlong Wang, Baizhao Li, Zhu Li, Juan Huang, Xinying Li   +5 more
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Stress, the Endoplasmic Reticulum, and Insulin Resistance

Annals of the New York Academy of Sciences, 2006
Abstract:  Stress, such as nutrient deprivation, viral infections, inflammation, heat shock, or lipid accumulation, imposes a serious threat to the body. These stimuli, acting both on the central control stations of the stress system and its final effectors, catecholamines and glucocorticoids, and on the peripheral target tissues, can modulate insulin
Tsiotra, Panayoula C., Tsigos, Constantine   +1 more
openaire   +3 more sources

Stress Management: How the Endoplasmic Reticulum Mitigates Protein Misfolding and Oxidative Stress by the Dual Role of Glutathione Peroxidase 8

Biomolecules
The endoplasmic reticulum mediates essential processes such as protein folding, transport, and post-translational modifications. Disruptions in endoplasmic reticulum function can lead to the accumulation of unfolded or misfolded proteins, initiating ...
Yong Yang, Hao Peng, Danni Meng, Zizhu Fa, Chen Yao, Xinyu Lin, Joel Schick, Xiang Jin   +7 more
doaj   +1 more source

Endoplasmic reticulum stress-induced apoptosis in the penumbra aggravates secondary damage in rats with traumatic brain injury

Neural Regeneration Research, 2016
Neuronal apoptosis is mediated by intrinsic and extrinsic signaling pathways such as the membrane-mediated, mitochondrial, and endoplasmic reticulum stress pathways.
Guo-zhu Sun, Fen-fei Gao, Zong-mao Zhao, Hai Sun, Wei Xu, Li-wei Wu, Yong-chang He   +6 more
doaj   +1 more source

EFP1 is an ER stress-induced glycoprotein which interacts with the pro-apoptotic protein Par-4 [PDF]

, 2009
We have isolated the rat ortholog of EFP1 (EF-hand binding protein 1) as a novel interaction partner of the pro-apoptotic protein Par-4 (prostate apoptosis response-4).
Maertens, Barbara, Koplin, Ansgar, Appel, Sarah, Preuss, Ute, Vetterkind, Susanne, Boosen, Meike   +5 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly. [PDF]

, 2001
Cargo selection and export from the endoplasmic reticulum is mediated by the COPII coat machinery that includes the small GTPase Sar1 and the Sec23/24 and Sec13/31 complexes.
Bannykh, Sergei, Balch, WE, William E. Balch, Aridor, M, Balch, William E, Fish, KN, Lippincott-Schwartz, J, Fish, Kenneth N, Lippincott-Schwartz, Jennifer, Meir Aridor, Weissman, Jacques, Sergei Bannykh, Jacques Weissman, Bannykh, S, Roberts, Theresa H, Weissman, J, Aridor, Meir, Jennifer Lippincott-Schwartz, Roberts, TH, Theresa H. Roberts, Kenneth N. Fish   +20 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source