Results 61 to 70 of about 2,960,809 (306)

Endoplasmic Reticulum Stress in Metabolic Disorders [PDF]

Cells, 2018
Metabolic disorders have become among the most serious threats to human health, leading to severe chronic diseases such as obesity, type 2 diabetes, non-alcoholic fatty liver disease, as well as cardiovascular diseases. Interestingly, despite the fact that each of these maladies has different physiological and clinical symptoms, they appear to share ...
Rose Ghemrawi, Shyue-Fang Battaglia-Hsu, Carole Arnold   +2 more
openaire   +5 more sources

Protein kinase R-like endoplasmic reticulum kinase pathway and diabetic kidney disease

Linchuang shenzangbing zazhi, 2020
Endoplasmic reticulum stress is closely related to the occurrence and development of diabetic kidney disease.As an important signaling pathway induced by endoplasmic reticulum stress,protein kinase R-like endoplasmic reticulum kinase(PERK)pathway can ...
庞欣欣, 彭紫凝, 邢玉凤, 张雅歌, 石秀杰, 韩佳瑞   +5 more
doaj  

Alginate Oligosaccharide Prevents Acute Doxorubicin Cardiotoxicity by Suppressing Oxidative Stress and Endoplasmic Reticulum-Mediated Apoptosis

Marine Drugs, 2016
Doxorubicin (DOX) is a highly potent chemotherapeutic agent, but its usage is limited by dose-dependent cardiotoxicity. DOX-induced cardiotoxicity involves increased oxidative stress and activated endoplasmic reticulum-mediated apoptosis.
Jun-Jie Guo, Lei-Lei Ma, Hong-Tao Shi, Jian-Bing Zhu, Jian Wu, Zhi-Wen Ding, Yi An, Yun-Zeng Zou, Jun-Bo Ge   +8 more
doaj   +1 more source

Folding-competent and folding-defective forms of Ricin A chain have different fates following retrotranslocation from the endoplasmic reticulum [PDF]

, 2010
We report that a toxic polypeptide retaining the potential to refold upon dislocation from the endoplasmic reticulum (ER) to the cytosol (ricin A chain; RTA) and a misfolded version that cannot (termed RTAΔ), follow ER-associated degradation (ERAD ...
Ladds, Graham, Manfred J. Schmitt, Robert A. Spooner, Stuart C. H. Allen, Schmitt, Manfred J., Shuyu Li, Christopher P. Guise, Lord, J M, Allen, Stuart C. H., Li, Shuyu, Roberts, L. M. (Lynne M.), Allen, Stuart C H, Schnöder, Tina, Spooner, R A, Spooner, Robert A., Ladds, G, Roberts, R M, Tina Schnöder, Guise, C P, Schmitt, M J, Guise, Christopher P., Graham Ladds, Lord, Mike, Lynne M. Roberts, J. Michael Lord, Li, S, Schnoder, T   +26 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Endoplasmic reticulum stress in diseases

MedComm
AbstractThe endoplasmic reticulum (ER) is a key organelle in eukaryotic cells, responsible for a wide range of vital functions, including the modification, folding, and trafficking of proteins, as well as the biosynthesis of lipids and the maintenance of intracellular calcium homeostasis. A variety of factors can disrupt the function of the ER, leading
Yingying Liu, Chunling Xu, Renjun Gu, Ruiqin Han, Ziyun Li, Xianrong Xu   +5 more
openaire   +3 more sources

The clinical significance of endoplasmic reticulum stress related genes in non-small cell lung cancer and analysis of single nucleotide polymorphism for CAV1

Frontiers in Molecular Biosciences
In recent years, protein homeostasis imbalance caused by endoplasmic reticulum stress has become a major hallmark of cancer. Studies have shown that endoplasmic reticulum stress is closely related to the occurrence, development, and drug resistance of ...
Shuang Li, Junting Chen, Baosen Zhou
doaj   +1 more source

Cytosolic entry of Shiga-like toxin A chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p [PDF]

, 2012
Background Escherichia coli Shiga-like toxin 1 normally traffics to the endoplasmic reticulum (ER) in sensitive mammalian cells from where the catalytic A chain (SLTxA1) dislocates to the cytosol to inactivate ribosomes.
Lynne M. Roberts (150050), J Michael Lord, Roberts Lynne M., Spooner, Robert A., Hampton Randolph Y., Lord J. Michael, Robert A. Spooner (150027), Spooner Robert A., Lord, J. Michael, Shuyu Li (18735), Roberts, Lynne M., Randolph Y Hampton, Lynne M Roberts, Shuyu Li, Lord, Mike, J. Michael Lord (150042), Li, Shuyu, Roberts, L. M. (Lynne M.), Robert A Spooner, Randolph Y. Hampton (150034), Li Shuyu, Hampton, Randolph Y.   +21 more
core   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Unfolded protein response in endoplasmic reticulum stress associated with retinal degenerative diseases: A promising therapeutic target

Neural Regeneration Research
The unfolded protein response is a cellular pathway activated to maintain proteostasis and prevent cell death when the endoplasmic reticulum is overwhelmed by unfolded proteins.
Hongbing Zhang, Yalin Mu, Hongsong Li, Xiaogang Li   +3 more
doaj   +1 more source