Results 31 to 40 of about 118,726 (215)

Gallic Acid Prevents the Oxidative and Endoplasmic Reticulum Stresses in the Hippocampus of Adult-Onset Hypothyroid Rats

Frontiers in Pharmacology, 2021
Thyroid hormone is essential for hippocampal redox environment and neuronal viability in adulthood, where its deficiency causes hypothyroidism related to oxidative and endoplasmic reticulum stresses in the hippocampus, resulting in neuronal death.
Vanessa Blas-Valdivia, Margarita Franco-Colín, Placido Rojas-Franco, Alberto Chao-Vazquez, Alberto Chao-Vazquez, Edgar Cano-Europa   +5 more
doaj   +1 more source

The association of shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect [PDF]

, 2006
Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx).
Platt, Frances M., Smith, Daniel C., Jarvis, Rosemary M., Lord, J. Michael, Roberts, Lynne M., Jarvis, R. M., Sillence, Daniel J., Johannes, Ludger, Falguires, T., Falguières, Thomas, Lord, Mike, Roberts, L. M. (Lynne M.), Smith, D. C., Roberts, Lynne, M, Jarvis, Rosemary, M, Sillence, Daniel, J, Smith, Daniel, C, Platt, Frances, M   +17 more
core   +1 more source

Mitochondria-associated endoplasmic reticulum membranes and calcium ion exchange: A novel direction for aging and neurodegenerative diseases

Neural Regeneration Research
Mitochondria-associated endoplasmic reticulum membranes serve as crucial signaling hubs mediating communication between the endoplasmic reticulum and mitochondria, and play a central role in calcium ion exchange.
Yuxuan Yang, Mengjie Chen, Lingling Ding, Jiaxi Liu, Jiansheng Luo, Ruyu Yan, Jiaqi Ning, Siyi Xie, Xiang Li, Zhihao Ren, Ruiling Zhou, Zhuoya Chen   +11 more
doaj   +1 more source

Transcriptional analysis implicates endoplasmic reticulum stress in bovine spongiform encephalopathy. [PDF]

, 2010
Bovine spongiform encephalopathy (BSE) is a fatal, transmissible, neurodegenerative disease of cattle. To date, the disease process is still poorly understood.
Xiang, Wei, Hans A. Kretzschmar, Hans A Kretzschmar, Kretzschmar, Hans A., Yue Tang, Otto Windl, Terry, Linda, Windl, Otto, Tang, Yue, Linda Terry, Wei Xiang   +10 more
core   +2 more sources

Stress-induced neuroprotective effects of epiregulin and amphiregulin. [PDF]

PLoS ONE, 2015
Members of the epidermal growth factor family play important roles in the regulation of cell growth, proliferation, and survival. However, the specific roles of each epidermal growth factor family member with respect to brain injury are not well ...
Libin Zhan, Luping Zheng, Toru Hosoi, Yasunobu Okuma, Yasuyuki Nomura   +4 more
doaj   +1 more source

The mutualistic fungus Piriformospora indica colonizes Arabidopsis roots by inducing an endoplasmic reticulum stress-triggered caspase-dependent cell death [PDF]

, 2012
In Arabidopsis thaliana roots, the mutualistic fungus Piriformospora indica initially colonizes living cells, which die as the colonization proceeds. We aimed to clarify the molecular basis of this colonization-associated cell death.
Zechmann, B., Kogel, Karl-Heinz, Schäfer, Patrick, Qiang, X., Reitz, M. U.   +4 more
core   +1 more source

Targeting the calcium ATPase to the endoplasmic reticulum

, 2009
The sarco/endoplasmic reticulum calcium ATPase (SERCA) pumps calcium from thecytoplasm into the lumen of the endoplasmic or sarcoplasmic reticulum (ER/SR), removingexcess Ca2+ from the cytoplasm and replenishing ER/SR Ca2+ stores. SERCA is located inboth
Watson, Helen Rachel
core   +2 more sources

Folding-competent and folding-defective forms of Ricin A chain have different fates following retrotranslocation from the endoplasmic reticulum [PDF]

, 2010
We report that a toxic polypeptide retaining the potential to refold upon dislocation from the endoplasmic reticulum (ER) to the cytosol (ricin A chain; RTA) and a misfolded version that cannot (termed RTAΔ), follow ER-associated degradation (ERAD ...
Ladds, Graham, Manfred J. Schmitt, Robert A. Spooner, Stuart C. H. Allen, Schmitt, Manfred J., Shuyu Li, Christopher P. Guise, Lord, J M, Allen, Stuart C. H., Li, Shuyu, Roberts, L. M. (Lynne M.), Allen, Stuart C H, Schnöder, Tina, Spooner, R A, Spooner, Robert A., Ladds, G, Roberts, R M, Tina Schnöder, Guise, C P, Schmitt, M J, Guise, Christopher P., Graham Ladds, Lord, Mike, Lynne M. Roberts, J. Michael Lord, Li, S, Schnoder, T   +26 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Transport of cholesterol from the endoplasmic reticulum to the plasma membrane is constitutive in CaCo-2 cells and differs from the transport of plasma membrane cholesterol to the endoplasmic reticulum

Journal of Lipid Research, 1998
The transport of newly synthesized cholesterol from its site of synthesis, the endoplasmic reticulum, to the plasma membrane was studied in CaCo-2 cells. The appearance of newly synthesized cholesterol on the cell surface was rapid. By 30 min, 50% of the
F. Jeffrey Field, Ella Born, Shubha Murthy, Satya N. Mathur   +3 more
doaj   +1 more source