Ferroptosis and endoplasmic reticulum stress in ischemic stroke
Neural Regeneration Research, 2023 Ferroptosis is a form of non-apoptotic programmed cell death, and its mechanisms mainly involve the accumulation of lipid peroxides, imbalance in the amino acid antioxidant system, and disordered iron metabolism.
Yina Li +6 more
doaj +2 more sources
Pharmacological targeting of endoplasmic reticulum stress in disease
Nature Reviews Drug Discovery, 2021 Stefan Marciniak +2 more
exaly +2 more sources
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
Nature Cell Biology, 2011 The ability to respond to perturbations in endoplasmic reticulum (ER) function is a fundamentally important property of all cells, but ER stress can also lead to apoptosis.
David Ron, Ira Tabas
exaly +2 more sources
NAA10 and BTRC drive CREBRF degradation in endoplasmic reticulum stress and renal tubular injury [PDF]
Journal of Diabetes InvestigationBackground Diabetic kidney disease (DKD) is a frequent complication associated with diabetes. CREBRF was reported to be closely associated with endoplasmic reticulum stress. However, the upstream regulatory mechanism by which CREBRF modulates endoplasmic
Sitian Fang +3 more
doaj +2 more sources
Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis
Breast Cancer: Basic and Clinical Research, 2011 Endoplasmic reticulum calcium homeostasis is involved in several essential cell functions including cell proliferation, protein synthesis, stress responses or secretion.
Béla Papp, Jean-Philippe Brouland
doaj +2 more sources
Research progress on the role of endoplasmic reticulum stress in osteoarthritis [PDF]
Jichu yixue yu linchuang, 2023 Osteoarthritis is a common degenerative disease in which endoplasmic reticulum stress(ER stress) plays an important role in the pathogenesis of chondrocyte apoptosis.
JIN Tao, YANG Qingshan, WU Shujin, ZHU Xiaoyan, SHI Yucong, NIU Jianxiong, LIU Lin
doaj +1 more source
Updates on “Endoplasmic Reticulum Redox” [PDF]
Antioxidants & Redox Signaling, 2012 Appenzeller-Herzog, Christian +1 more
openaire +6 more sources
Protein quality control and aggregation in the endoplasmic reticulum: From basic to bedside
Frontiers in Cell and Developmental Biology, 2023 Endoplasmic reticulum (ER) is the largest membrane-bound compartment in all cells and functions as a key regulator in protein biosynthesis, lipid metabolism, and calcium balance.
Guofang Chen +5 more
doaj +1 more source
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 The endoplasmic reticulum (ER) functions as a quality-control organelle for protein homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated degradation, protein chaperons, and autophagy.
Xingyi Chen +4 more
semanticscholar +1 more source
Reshaping Endoplasmic Reticulum Quality Control Through the Unfolded Protein Response
Molecules and Cells, 2022 SUMMARY Endoplasmic reticulum quality control (ERQC) pathways comprised of chaperones, folding enzymes, and degradation factors ensure the fidelity of ER protein folding and trafficking to downstream secretory environments.
R. Wiseman +2 more
semanticscholar +1 more source