Results 11 to 20 of about 755,597 (345)

Pharmacological targeting of endoplasmic reticulum stress in disease

Nature Reviews Drug Discovery, 2021
S. Marciniak, Joseph E. Chambers, D. Ron
semanticscholar   +3 more sources

Endoplasmic reticulum stress signals in the tumour and its microenvironment

Nature Reviews Cancer, 2020
Xi Chen, J. Cubillos-Ruiz
semanticscholar   +3 more sources

Endoplasmic reticulum stress-mediated cell death in liver injury

Cell Death and Disease, 2022
The endoplasmic reticulum is an important intracellular organelle that plays an important role in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) are induced when the body is exposed to adverse ...
Jian Zhang, Jiafu Guo, Nannan Yang, Yan Huang, Tingting Hu, Chaolong Rao   +5 more
semanticscholar   +1 more source

Endoplasmic reticulum stress and lipids in health and diseases.

Progress in lipid research, 2022
The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many cellular pathways, including protein synthesis, protein quality control and lipid synthesis. When one or multiple ER roles are dysregulated and saturated, the ER enters
Cenk Celik, Stella Yue Ting Lee, W. S. Yap, Guillaume Thibault   +3 more
semanticscholar   +1 more source

Mitochondrial-Endoplasmic Reticulum Communication-Mediated Oxidative Stress and Autophagy

BioMed Research International, 2022
Oxidative stress is an imbalance between free radicals and the antioxidant system causing overgeneration of free radicals (oxygen-containing molecules) ultimately leading to oxidative damage in terms of lipid peroxidation, protein denaturation, and DNA ...
Xiao-qing Liu, Riaz Hussain, Khalid Mehmood, Zhaoxin Tang, Hui Zhang, Ying Li   +5 more
semanticscholar   +1 more source

Endoplasmic Reticulum-Associated Protein Degradation.

Cold Spring Harbor Perspectives in Biology, 2022
Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated degradation (ERAD).
L. Krshnan, M. L. van de Weijer, Pedro Carvalho   +2 more
semanticscholar   +1 more source

A guide to understanding endoplasmic reticulum stress in metabolic disorders

Molecular Metabolism, 2021
Background The global rise of metabolic disorders, such as obesity, type 2 diabetes, and cardiovascular disease, demands a thorough molecular understanding of the cellular mechanisms that govern health or disease.
Imke L. Lemmer, N. Willemsen, N. Hilal, A. Bartelt   +3 more
semanticscholar   +1 more source

Endoplasmic reticulum stress and pulmonary hypertension

Pulmonary Circulation, 2020
Pulmonary hypertension is a fatal disease of which pulmonary vasculopathy is the main pathological feature resulting in the mean pulmonary arterial pressure higher than 25 mmHg.
Yanan Hu, Wenhao Yang, Liang Xie, Tao Liu, Hanmin Liu, Bin Liu   +5 more
doaj   +1 more source

Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway

Journal of Inflammation, 2023
Background Soluble Epoxide Hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids and critically affects airway inflammation in chronic obstructive pulmonary disease (COPD).
Yue Yu, Ailin Yang, Xin He, Bo Wu, Yanjun Wu, Yunxiao Li, Shan Nie, Bo Xu, Haoyan Wang, Ganggang Yu   +9 more
doaj   +1 more source

Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes [PDF]

, 2018
Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Allard, Camille, Alvarez-Mercado, Ana I, Arvan, Peter, Coons, Laurel A, Floyd, Z. Elizabeth, Fuselier, Taylor, Hewitt, Sylvia C, Kim, Jun Ho, Korach, Kenneth S, Levin, Ellis R, Mauvais-Jarvis, Franck, Urano, Fumihiko, Xu, Beibei   +12 more
core   +2 more sources