Results 51 to 60 of about 636,928 (251)

Transmembrane domain length is responsible for the ability of a plant reticulon to shape endoplasmic reticulum tubules in vivo [PDF]

, 2010
Reticulons are integral endoplasmic reticulum (ER) membrane proteins that have the ability to shape the ER into tubules. It has been hypothesized that their unusually long conserved hydrophobic regions cause reticulons to assume a wedge-like topology ...
Eastmond, Peter J., Hawes, Chris, Craddock, Christian P., Peter J. Eastmond, Eastmond, Peter J, Tolley, Nicholas, Hawes, C. R., Frigerio, Lorenzo, John Runions, Craddock, Christian P, Lorenzo Frigerio, Nicholas Tolley, Christian P. Craddock, Chris Hawes, Runions, John, Imogen Sparkes, Sparkes, Imogen   +16 more
core   +1 more source

Surveying the floodgates: Estimating protein flux into the endoplasmic reticulum lumen in Saccharomyces cerevisiae

Frontiers in Physiology, 2014
Endoplasmic reticulum resident proteins, along with all proteins traveling through the secretory pathway must enter endoplasmic reticulum lumen through membrane-embedded translocons.
Michael eVincent, Mark eWhidden, Santiago eSchnell, Santiago eSchnell, Santiago eSchnell   +4 more
doaj   +1 more source

Septin-dependent compartmentalization of the endoplasmic reticulum during yeast polarized growth [PDF]

, 2005
Polarized cells frequently use diffusion barriers to separate plasma membrane domains. It is unknown whether diffusion barriers also compartmentalize intracellular organelles.
Cosima Luedeke, Ivo Sbalzarini, Frei, S. B., Sbalzarini, I., Anne Spang, Barral, Y., Spang, A. ; https://orcid.org/, Yves Barral, Luedeke, C., Schwarz, H., Heinz Schwarz, Stéphanie Buvelot Frei, Spang, A., Buvelot Frei, S.   +13 more
core   +1 more source

The overexpression of nuclear envelope protein Lap2β induces endoplasmic reticulum reorganisation via membrane stacking

Biology Open, 2012
Summary Some nuclear envelope proteins are localised to both the nuclear envelope and the endoplasmic reticulum; therefore, it seems plausible that even small amounts of these proteins can influence the organisation of the endoplasmic reticulum. A simple
Ekaterina G. Volkova, Sergey S. Abramchuk, Eugene V. Sheval   +2 more
doaj   +1 more source

Destroy and exploit: catalyzed removal of hydroperoxides from the endoplasmic reticulum [PDF]

, 2013
Peroxidases are enzymes that reduce hydroperoxide substrates. In many cases, hydroperoxide reduction is coupled to the formation of a disulfide bond, which is transferred onto specific acceptor molecules, the so-called reducing substrates.
Thomas Ramming, Ramming, Thomas, Appenzeller-Herzog, Christian, Christian Appenzeller-Herzog   +3 more
core   +1 more source

Neuroprotective effects of atorvastatin against cerebral ischemia/reperfusion injury through the inhibition of endoplasmic reticulum stress

Neural Regeneration Research, 2015
Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear.
Jian-wen Yang, Zhi-ping Hu
doaj   +1 more source

Transcriptional analysis implicates endoplasmic reticulum stress in bovine spongiform encephalopathy. [PDF]

, 2010
Bovine spongiform encephalopathy (BSE) is a fatal, transmissible, neurodegenerative disease of cattle. To date, the disease process is still poorly understood.
Xiang, Wei, Hans A. Kretzschmar, Hans A Kretzschmar, Kretzschmar, Hans A., Yue Tang, Otto Windl, Terry, Linda, Windl, Otto, Tang, Yue, Linda Terry, Wei Xiang   +10 more
core   +2 more sources

Membrane-associated RING ubiquitin ligase RNF-121 and advancement of cancer [PDF]

Cellular, Molecular and Biomedical Reports
Exploration of E3 ubiquitin ligases as potential therapeutic targets has been ongoing for two to three decades. Various chemicals and drugs have been developed to either upregulate or inhibit the activity of E3 ligases, aiming to mitigate several ...
Somesh Roy
doaj   +1 more source

Endoplasmic reticulum stress—a key guardian in cancer

Cell Death Discovery
Endoplasmic reticulum stress (ERS) is a cellular stress response characterized by excessive contraction of the endoplasmic reticulum (ER). It is a pathological hallmark of many diseases, such as diabetes, obesity, and neurodegenerative diseases.
Wenlong Zhang, Yidan Shi, L. Oyang, Shiwen Cui, Shizhen Li, Jinyun Li, Lin Liu, Yun Li, Mingjing Peng, Shiming Tan, Longzheng Xia, Jinguan Lin, Xuemeng Xu, Nayiyuan Wu, Qiu Peng, Yan-Yan Tang, Xia Luo, Q. Liao, Xianjie Jiang, Yu-Juan Zhou   +19 more
semanticscholar   +1 more source

The association of shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect [PDF]

, 2006
Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx).
Falguières, T, Platt, Frances M., Platt, Frances, Roberts, LM, Sillence, DJ, Smith, Daniel C., Jarvis, Rosemary M., Lord, JM, Smith, DC, Lord, J. Michael, Roberts, Lynne M., Jarvis, R. M., Sillence, Daniel J., Johannes, Ludger, Falguires, T., Falguières, Thomas, Lord, Mike, Johannes, L, Roberts, L. M. (Lynne M.), Jarvis, RM, Smith, D. C.   +20 more
core   +1 more source