Results 51 to 60 of about 404,308 (207)

Dynamic insertion of membrane proteins at the endoplasmic reticulum [PDF]

, 2005
Most eukaryotic membrane proteins are cotranslationally integrated into the endoplasmic reticulum membrane by the Sec61 translocation complex. They are targeted to the translocon by hydrophobic signal sequences which induce the translocation of either ...
Higy, Marie
core   +1 more source

The physiological functions of mammalian endoplasmic oxidoreductin 1: on disulfides and more [PDF]

, 2012
Significance: The oxidative process of disulfide-bond formation is essential for the folding of most secretory and membrane proteins in the endoplasmic reticulum (ER).
Ramming, Thomas, Appenzeller-Herzog, Christian   +1 more
core   +1 more source

Transport of cholesterol from the endoplasmic reticulum to the plasma membrane is constitutive in CaCo-2 cells and differs from the transport of plasma membrane cholesterol to the endoplasmic reticulum

Journal of Lipid Research, 1998
The transport of newly synthesized cholesterol from its site of synthesis, the endoplasmic reticulum, to the plasma membrane was studied in CaCo-2 cells. The appearance of newly synthesized cholesterol on the cell surface was rapid. By 30 min, 50% of the
F. Jeffrey Field, Ella Born, Shubha Murthy, Satya N. Mathur   +3 more
doaj   +1 more source

Endoplasmic reticulum H₂O₂ : Ero1-driven generation and GPx-mediated detoxification [PDF]

, 2014
Endoplasmic reticulum (ER) oxidoreductin 1 alpha (Ero1alpha) is an ER-resident oxidase, which utilizes molecular oxygen (O2) as terminal electron acceptor to produce disulfide bonds and hydrogen peroxide (H2O2).
Ramming, Thomas
core   +1 more source

Cigarette smoke toxin hydroquinone and misfolding pancreatic lipase variant cooperatively promote endoplasmic reticulum stress and cell death.

PLoS ONE, 2022
Mutation-induced protein misfolding of pancreatic secretory enzymes and consequent endoplasmic reticulum stress can cause chronic pancreatitis. A recent study revealed that cigarette smoke also increases the risk of the disease through endoplasmic ...
Norbert Kassay, Vanda Toldi, József Tőzsér, András Szabó   +3 more
doaj   +2 more sources

Ferroptosis and endoplasmic reticulum stress in ischemic stroke

Neural Regeneration Research
Ferroptosis is a form of non-apoptotic programmed cell death, and its mechanisms mainly involve the accumulation of lipid peroxides, imbalance in the amino acid antioxidant system, and disordered iron metabolism.
Yina Li, Mingyang Li, Shi Feng, Qingxue Xu, Xu Zhang, Xiaoxing Xiong, Lijuan Gu   +6 more
doaj   +1 more source

Calcium bridges built by mitochondria-associated endoplasmic reticulum membranes: potential targets for neural repair in neurological diseases

Neural Regeneration Research
The exchange of information and materials between organelles plays a crucial role in regulating cellular physiological functions and metabolic levels. Mitochondria-associated endoplasmic reticulum membranes serve as physical contact channels between the ...
Yichen Peng, Li Zhou, Yaju Jin, Danli Wu, Na Chen, Chengcai Zhang, Hongpeng Liu, Chunlan Li, Rong Ning, Xichen Yang, Qiuyue Mao, Jiaxin Liu, Pengyue Zhang   +12 more
doaj   +1 more source

Effect of hypoxia, glutamine and glucose deprivation on the expression of mRNA of the retinoblastoma binding proteins in glioma cells

Біологічні студії, 2011
Hypoxia and ischemia, as well as endoplasmic reticulum stress, are principal factors which are necessary for tumor neovascularization and growth. We have studied the effect of blocking the endoplasmic reticulum – nuclei-1, the main signaling enzyme of ...
D. O. Minchenko, L. L. Karbovskyi, S. V. Danylovsky, M. Moenner, O. H. Minchenko   +4 more
doaj   +1 more source

Endoplasmic reticulum–mitochondria interplay in chronic pain: The calcium connection

Molecular Pain, 2020
Chronic pain is a debilitating condition that affects roughly a third to a half of the world’s population. Despite its substantial effect on society, treatment for chronic pain is modest, at best, notwithstanding its side effects.
Muhammad Saad Yousuf, Aislinn D Maguire, Thomas Simmen, Bradley J Kerr   +3 more
doaj   +1 more source

RBM10 Regulates Embryonic Trophoblast Injury via Endoplasmic Reticulum Stress

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: Previous studies shown that RNA binding motif proteins (RBM) participate in regulating various physiological processes such as cell autophagy, proliferation, and apoptosis, and are abnormally highly expressed in placental trophoblast cells ...
Xiao Chen, Juan Du, Liyu Chen, Lanlan Wang, Gang Xin   +4 more
doaj   +1 more source