Results 61 to 70 of about 636,928 (251)

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

Neural Regeneration Research
The endoplasmic reticulum, a key cellular organelle, regulates a wide variety of cellular activities. Endoplasmic reticulum autophagy, one of the quality control systems of the endoplasmic reticulum, plays a pivotal role in maintaining endoplasmic ...
Xiu-Yun Zhao, De-En Xu, Ming-Lei Wu, Ji-Chuan Liu, Zi-Ling Shi, Quan-Hong Ma   +5 more
doaj   +1 more source

Gallic Acid Prevents the Oxidative and Endoplasmic Reticulum Stresses in the Hippocampus of Adult-Onset Hypothyroid Rats

Frontiers in Pharmacology, 2021
Thyroid hormone is essential for hippocampal redox environment and neuronal viability in adulthood, where its deficiency causes hypothyroidism related to oxidative and endoplasmic reticulum stresses in the hippocampus, resulting in neuronal death.
Vanessa Blas-Valdivia, Margarita Franco-Colín, Placido Rojas-Franco, Alberto Chao-Vazquez, Alberto Chao-Vazquez, Edgar Cano-Europa   +5 more
doaj   +1 more source

Dynamic insertion of membrane proteins at the endoplasmic reticulum [PDF]

, 2005
Most eukaryotic membrane proteins are cotranslationally integrated into the endoplasmic reticulum membrane by the Sec61 translocation complex. They are targeted to the translocon by hydrophobic signal sequences which induce the translocation of either ...
Higy, Marie
core   +1 more source

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]

, 2010
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Sue E Crawford, Mary K Estes, Mary K. Estes, Susana Guix, Kazuhiko Katayama, Sue E. Crawford, Tyler M Sharp, Tyler M. Sharp, Guix Arnau, Susana, Katayama, K., Guix Susana, Crawford, Sue E., Estes, M. K., Katayama Kazuhiko, Estes Mary K., Sharp, T. M., Sharp Tyler M., Crawford Sue E.   +17 more
core   +3 more sources

Mitochondria-associated endoplasmic reticulum membranes and calcium ion exchange: A novel direction for aging and neurodegenerative diseases

Neural Regeneration Research
Mitochondria-associated endoplasmic reticulum membranes serve as crucial signaling hubs mediating communication between the endoplasmic reticulum and mitochondria, and play a central role in calcium ion exchange.
Yuxuan Yang, Mengjie Chen, Lingling Ding, Jiaxi Liu, Jiansheng Luo, Ruyu Yan, Jiaqi Ning, Siyi Xie, Xiang Li, Zhihao Ren, Ruiling Zhou, Zhuoya Chen   +11 more
doaj   +1 more source

Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases

International Journal of Molecular Sciences, 2020
The endoplasmic reticulum (ER) is an important organelle involved in protein quality control and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress, followed by an adaptive response via the activation of the unfolded ...
Rose Ghemrawi, Mostafa Khair
semanticscholar   +1 more source

Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation [PDF]

, 2012
Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately ...
Amanda Denuc, Marfany Gemma, Denuc Isern, Amanda, Todi, S. V., Burr, A. A., Gemma Marfany, Blount Jessica R., Sokol V Todi, Todi Sokol V., Marfany i Nadal, Gemma, Jessica R Blount, Denuc Amanda, Blount, J. R., Aaron A Burr, Burr Aaron A.   +14 more
core   +2 more sources

Stress-induced neuroprotective effects of epiregulin and amphiregulin. [PDF]

PLoS ONE, 2015
Members of the epidermal growth factor family play important roles in the regulation of cell growth, proliferation, and survival. However, the specific roles of each epidermal growth factor family member with respect to brain injury are not well ...
Libin Zhan, Luping Zheng, Toru Hosoi, Yasunobu Okuma, Yasuyuki Nomura   +4 more
doaj   +1 more source

Endoplasmic Reticulum Stress Signaling in Cancer Cells.

American Journal of Pathology, 2020
To survive, cancers cells must resist numerous internal and environmental insults associated with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER).
Scott A. Oakes
semanticscholar   +1 more source

The mutualistic fungus Piriformospora indica colonizes Arabidopsis roots by inducing an endoplasmic reticulum stress-triggered caspase-dependent cell death [PDF]

, 2012
In Arabidopsis thaliana roots, the mutualistic fungus Piriformospora indica initially colonizes living cells, which die as the colonization proceeds. We aimed to clarify the molecular basis of this colonization-associated cell death.
Zechmann, B., Kogel, Karl-Heinz, Schäfer, Patrick, Qiang, X., Reitz, M. U.   +4 more
core   +1 more source