Results 11 to 20 of about 162,922 (305)
The Unfolding Tale of the Unfolded Protein Response [PDF]
Cell, 2001 Surface and secreted proteins are synthesized in the endoplasmic reticulum where they must fold and assemble before being transported. Changes in the ER that interfere with their proper maturation initiate the unfolded protein response pathway. New studies have filled in a missing link between the yeast and mammalian pathways.
Ma, Yanjun, Hendershot, Linda M.
openaire +4 more sources
The unfolded protein response in immunity and inflammation. [PDF]
Nature Reviews Immunology, 2016 The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands associated with environmental forces.
a Bertolotti +189 more
core +3 more sources
IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress [PDF]
, 2020 IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress.
Acosta-Alvear +54 more
core +1 more source
Unfolded protein response in the COVID-19 context
Aging and Health Research, 2021 The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggests that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability.
Nektarios Barabutis
doaj +1 more source
Unfolded Protein Corona Surrounding Nanotubes Influence the Innate and Adaptive Immune System
Advanced Science, 2021 The plasma proteins around nanoparticles (NPs) form an outer protein corona, significantly influencing the subsequent immune response. However, it was uncertain whether the protein corona around NPs influences immune response.
Jun‐Young Park +6 more
doaj +1 more source
An unfolded protein-induced conformational switch activates mammalian IRE1. [PDF]
, 2017 The unfolded protein response (UPR) adjusts the cell's protein folding capacity in the endoplasmic reticulum (ER) according to need. IRE1 is the most conserved UPR sensor in eukaryotic cells.
Acosta-Alvear, Diego +5 more
core +3 more sources
The unfolded protein response has a protective role in yeast models of classic galactosemia
Disease Models & Mechanisms, 2014 Classic galactosemia is a human autosomal recessive disorder caused by mutations in the GALT gene (GAL7 in yeast), which encodes the enzyme galactose-1-phosphate uridyltransferase.
Evandro A. De-Souza +6 more
doaj +1 more source
Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors
Life Science Alliance, 2021 This work highlights the importance of the mitochondrial unfolded protein response in allowing organisms to survive external stressors through up-regulation of other stress response pathways.
Sonja K Soo +4 more
doaj +1 more source
UPR Signal Activation by Luminal Sensor Domains [PDF]
, 2013 The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis.
Ali, Maruf +2 more
core +1 more source
Untangling the unfolded protein response [PDF]
Cell Cycle, 2008 Resistance to current cancer therapies has forced scientists to investigate new avenues of therapy distinct from those aimed at single targets, to strategies based on targeting families of proteins, on which cancers rely for their ability to survive stress.
Emma L, Davenport +2 more
openaire +2 more sources