Results 11 to 20 of about 1,143,124 (339)
Unfolded protein response [PDF]
Current Biology, 2012 SummaryIn eukaryotic cells, the endoplasmic reticulum (ER) is a membrane-enclosed interconnected organelle responsible for the synthesis, folding, modification, and quality control of numerous secretory and membrane proteins.
Kaufman, Randal J., Cao, Stewart Siyan
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Unpacking the Unfolded Protein Response [PDF]
Cell, 2014 This year, the Albert Lasker Basic Medical Research Award will be shared by Peter Walter and Kazutoshi Mori for discoveries revealing the molecular mechanism of the unfolded protein response, an intracellular quality control system that detects harmful ...
Worby, Carolyn A., Dixon, Jack E.
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Molecular Biotechnology, 2006 The unfolded protein response (UPR) is a signal transduction network activated by inhibition of protein folding in the endoplasmic reticulum (ER).
Schröder, M.
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The unfolded protein response has a protective role in yeast models of classic galactosemia [PDF]
Disease Models & Mechanisms, 2014 Classic galactosemia is a human autosomal recessive disorder caused by mutations in the GALT gene (GAL7 in yeast), which encodes the enzyme galactose-1-phosphate uridyltransferase.
Evandro A. De-Souza +6 more
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New twists in the unfolded protein response
eLife, 2012 The response of S. pombe, also known as fission yeast, to misfolded proteins involves mechanisms that have not been observed in other species.
Benedict C S Cross, David Ron
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Evolution of the Unfolded Protein Response in Plants. [PDF]
Plant, Cell & Environment, 2021 The Unfolded Protein Response (UPR) in plants is elicited by endoplasmic reticulum stress which can be brought about by adverse environmental conditions.
S. Howell
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Putting the brakes on the unfolded protein response [PDF]
Journal of Cell Biology, 2011 The unfolded protein response is an ancient cellular pathway for rapidly responding to endoplasmic reticulum stress. Two studies in this issue (Rubio et al. 2011. J. Cell. Biol. doi:10.1083/jcb.201007077 and Chawla et al. 2011. J. Cell. Biol. doi:10.1083/
Robert H. Silverman, Frank Sicheri
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Signaling the mitochondrial unfolded protein response
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013 Mitochondria are compartmentalized organelles essential for numerous cellular functions including ATP generation, iron-sulfur cluster biogenesis, nucleotide and amino acid metabolism as well as apoptosis.
Nargund, Amrita M. +2 more
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, 2007 Protein folding is the rate-limiting step for secretion of recombinant proteins in nearly all expression systems. Overexpression of recombinant proteins easily exhausts the cellular protein folding machinery in the endoplasmic reticulum (ER).
Strudwick, N., Schröder, M.
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The unfolded protein response [PDF]
Journal of Cell Science, 2003 The endoplasmic reticulum (ER) is a principal site for folding and maturation of transmembrane, secretory and ER-resident proteins. Perturbations that alter ER homeostasis can lead to accumulation of unfolded proteins (UPs), which is a threat to all living cells.
Chuan Yin, Liu, Randal J, Kaufman
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