Results 11 to 20 of about 90,832 (259)
The unfolded protein response [PDF]
Journal of Cell Science, 2003 The endoplasmic reticulum (ER) is a principal site for folding and maturation of transmembrane, secretory and ER-resident proteins. Perturbations that alter ER homeostasis can lead to accumulation of unfolded proteins (UPs), which is a threat to all living cells.
Chuan Yin, Liu, Randal J, Kaufman
openaire +2 more sources
The unfolded protein response protects from tau neurotoxicity in vivo. [PDF]
PLoS ONE, 2010 The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in modulating the effects of aggregation prone cytosolic proteins has received less attention.
Carin A Loewen, Mel B Feany
doaj +1 more source
Indonesian Journal of Biotechnology, 2021 Plants activate the unfolded protein response as part of cellular adaptation, thereby maintaining the endoplasmic reticulum homeostasis during external stresses exposure.
Galang Rizki Ramadhan +3 more
doaj +1 more source
Unfolded protein response [PDF]
Current Biology, 2012 SummaryIn eukaryotic cells, the endoplasmic reticulum (ER) is a membrane-enclosed interconnected organelle responsible for the synthesis, folding, modification, and quality control of numerous secretory and membrane proteins. The processes of protein folding and maturation are highly assisted and scrutinized but are also sensitive to changes in ER ...
Cao, Stewart Siyan, Kaufman, Randal J.
openaire +2 more sources
The unfolded protein response [PDF]
Current Biology, 2005 Where does the UPR function? Between the endoplasmic reticulum (ER) and the nucleus of eukaryotic cells. All secreted proteins and proteins that reside in secretory compartments translocate as nascent peptide chains into the ER, where they may undergo folding, modification and assembly before assuming their functional conformations.
Chawla, Aditi, Niwa, Maho
openaire +2 more sources
Cellular Response to Unfolded Proteins in Depression [PDF]
Life, 2021 Despite many scientific studies on depression, there is no clear conception explaining the causes and mechanisms of depression development. Research conducted in recent years has shown that there is a strong relationship between depression and the endoplasmic reticulum (ER) stress.
Mateusz Kowalczyk +5 more
openaire +3 more sources
The Unfolding Tale of the Unfolded Protein Response [PDF]
Cell, 2001 Surface and secreted proteins are synthesized in the endoplasmic reticulum where they must fold and assemble before being transported. Changes in the ER that interfere with their proper maturation initiate the unfolded protein response pathway. New studies have filled in a missing link between the yeast and mammalian pathways.
Ma, Yanjun, Hendershot, Linda M.
openaire +2 more sources
Unfolded protein response in colorectal cancer
Cell & Bioscience, 2021 Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or the rectum. A growing number of researches prove that the unfolded protein response (UPR) is closely related to the occurrence and progression of colorectal ...
Jingjing Huang +8 more
doaj +1 more source
Unfolded protein response in myelin disorders
Neural Regeneration Research, 2020 Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions.
Wensheng Lin, Sarrabeth Stone
doaj +1 more source
Unpacking the Unfolded Protein Response [PDF]
Cell, 2014 This year, the Albert Lasker Basic Medical Research Award will be shared by Peter Walter and Kazutoshi Mori for discoveries revealing the molecular mechanism of the unfolded protein response, an intracellular quality control system that detects harmful misfolded proteins in the endoplasmic reticulum and then signals the nucleus to carry out corrective ...
Worby, Carolyn A., Dixon, Jack E.
openaire +2 more sources