Results 41 to 50 of about 1,143,124 (339)
Applied Microbiology and Biotechnology, 2021 Folding and processing of proteins in the endoplasmic reticulum (ER) are major impediments in the production and secretion of proteins from Pichia pastoris (Komagataella sp.).
Hana Raschmanová +4 more
semanticscholar +1 more source
Tidy up - The unfolded protein response in sepsis
Frontiers in Immunology, 2022 Pathogens, their toxic byproducts, and the subsequent immune reaction exert different forms of stress and damage to the tissue of the infected host. This stress can trigger specific transcriptional and post-transcriptional programs that have evolved to ...
Wolfgang Vivas +5 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2022 Ischemic stroke is an acute cerebrovascular disease characterized by sudden interruption of blood flow in a certain part of the brain, leading to serious disability and death.
Lei Wang +8 more
semanticscholar +1 more source
eLife, 2015 Eukaryotic cells possess a variety of signaling pathways that prevent accumulation of unfolded and misfolded proteins. Chief among these is the heat shock response (HSR), which is assumed to respond to unfolded proteins in the cytosol and nucleus alike ...
Yusuke Miyazaki +4 more
doaj +1 more source
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling [PDF]
, 2012 Many cellular processes including apoptosis, autophagy, translation, energy metabolism, and inflammation are controlled by the mammalian target of rapamycin (mTOR) kinase and the endoplasmic reticulum (ER) stress pathway, also known as the unfolded ...
Appenzeller-Herzog, Christian +1 more
core +1 more source
StresSeed: The Unfolded Protein Response During Seed Development
Frontiers in Plant Science, 2022 During seed development, the endoplasmic reticulum (ER) takes care of the synthesis and structural maturation of very high amounts of storage proteins in a relatively short time.
Alessandro Vitale, Emanuela Pedrazzini
doaj +1 more source
Genetics, 2022 We review the findings that establish that perturbations of various aspects of mitochondrial function, including oxidative phosphorylation, can promote lifespan extension, with different types of perturbations acting sometimes independently and ...
Cole M. Haynes, S. Hekimi
semanticscholar +1 more source
Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]
, 2013 We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Subedi, Kalpana +12 more
core +1 more source
Unfolded Protein Response in Arabidopsis [PDF]
, 2017 The unfolded protein response (UPR) is a highly regulated signaling pathway that is largely conserved across eukaryotes. It is essential for cell homeostasis under environmental and physiological conditions that perturb the protein folding in the endoplasmic reticulum (ER).
Cristina, Ruberti, Federica, Brandizzi
openaire +3 more sources
Haematologica, 2012 Background Multiple myeloma, a malignancy of the antibody-secreting plasma cells, remains incurable by current therapy. However, the proteasome inhibitor bortezomib and other new drugs are revolutionizing its treatment.
Silvia C. W. Ling +11 more
doaj +1 more source