The unfolded protein response in multiple sclerosis
Frontiers in Neuroscience, 2015 The unfolded protein response (UPR) occurs in response to endoplasmic reticulum (ER) stress caused by the accumulation of unfolded or misfolded proteins in the ER.
Wensheng eLin, Sarrabeth eStone
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Dicarbonyl stress, protein glycation and the unfolded protein response
Glycoconjugate Journal, 2021 The reactive dicarbonyl metabolite, methylglyoxal (MG), is increased in obesity and diabetes and is implicated in the development of insulin resistance, type 2 diabetes mellitus and vascular complications of diabetes.
N. Rabbani, M. Xue, Paul J Thornalley
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The endoplasmic reticulum in plant immunity and cell death [PDF]
, 2012 The endoplasmic reticulum (ER) is a highly dynamic organelle in eukaryotic cells and a major production site of proteins destined for vacuoles, the plasma membrane, or apoplast in plants.
Ruth eEichmann +5 more
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Fibrillary Glomerulonephritis, DNAJB9, and the Unfolded Protein Response
Glomerular Diseases, 2022 Background: Fibrillary glomerulonephritis (FGN) is found in approximately 1% of native kidney biopsies and was traditionally defined by glomerular deposition of fibrils larger than amyloid (12–24 nm diameter) composed of polyclonal IgG.
Nicole K. Andeen +5 more
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Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases
International Journal of Molecular Sciences, 2020 The endoplasmic reticulum (ER) is an important organelle involved in protein quality control and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress, followed by an adaptive response via the activation of the unfolded ...
Rose Ghemrawi, Mostafa Khair
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Visualization of protein-protein interactions in the secretory pathway of mammalian cells [PDF]
, 2006 An increasing number of human disorders are being linked to mutations in components of the secretory pathway. One example is combined blood coagulation factor V and VIII deficiency, an autosomal recessive disorder leading to hemophilia due to markedly ...
Nyfeler, Beat
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The Unfolded Protein Response and its potential role in Huntington's disease
, 2012 Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown.
Ravi K. R. Kalathur +2 more
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Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise [PDF]
, 2013 Pathological endoplasmic reticulum (ER) stress is tightly linked to the accumulation of reactive oxidants, which can be both upstream and downstream of ER stress.
Julia Birk +11 more
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The Unfolded Protein Response at the Tumor-Immune Interface
Frontiers in Immunology, 2022 The tumor-immune interface has surged to primary relevance in an effort to understand the hurdles facing immune surveillance and cancer immunotherapy.
Maurizio Zanetti +3 more
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Unfolded Protein Response and Macroautophagy in Alzheimer’s, Parkinson’s and Prion Diseases
Molecules, 2015 Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis susceptible to age-related changes and neurodegeneration. Two key
Irina Milisav +2 more
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