Results 61 to 70 of about 1,143,124 (339)

The mutualistic fungus Piriformospora indica colonizes Arabidopsis roots by inducing an endoplasmic reticulum stress-triggered caspase-dependent cell death [PDF]

, 2012
In Arabidopsis thaliana roots, the mutualistic fungus Piriformospora indica initially colonizes living cells, which die as the colonization proceeds. We aimed to clarify the molecular basis of this colonization-associated cell death.
Zechmann, B., Kogel, Karl-Heinz, Schäfer, Patrick, Qiang, X., Reitz, M. U.   +4 more
core   +1 more source

Stress Management: How the Endoplasmic Reticulum Mitigates Protein Misfolding and Oxidative Stress by the Dual Role of Glutathione Peroxidase 8

Biomolecules
The endoplasmic reticulum mediates essential processes such as protein folding, transport, and post-translational modifications. Disruptions in endoplasmic reticulum function can lead to the accumulation of unfolded or misfolded proteins, initiating ...
Yong Yang, Hao Peng, Danni Meng, Zizhu Fa, Chen Yao, Xinyu Lin, Joel Schick, Xiang Jin   +7 more
doaj   +1 more source

Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08)

Haematologica, 2016
Downregulation of the unfolded protein response mediates proteasome inhibitor resistance in multiple myeloma. The Human Immunodeficieny Virus protease inhibitor nelfinavir activates the unfolded protein response in vitro.
Christoph Driessen, Marianne Kraus, Markus Joerger, Hilde Rosing, Jürgen Bader, Felicitas Hitz, Catherine Berset, Alexandros Xyrafas, Hanne Hawle, Gregoire Berthod, Hermann S. Overkleeft, Christiana Sessa, Alwin Huitema, Thomas Pabst, Roger von Moos, Dagmar Hess, Ulrich J.M. Mey   +16 more
doaj   +1 more source

Unfolded Protein Response in Lung Health and Disease

Frontiers in Medicine, 2020
The unfolded protein response (UPR) is a complex element, destined to protect the cells against a diverse variety of extracellular and intracellular challenges. UPR activation devises highly efficient responses to counteract cellular threats.
Nektarios Barabutis
doaj   +1 more source

The role of the unfolded protein response pathway in bone homeostasis and potential therapeutic target in cancer-associated bone disease

Bone Research
The unfolded protein response pathway is an evolutionarily conserved cytoprotective signaling cascade, essential for cell function and survival. Unfolded protein response signaling is tightly integrated with bone cell differentiation and function, and ...
Molly E. Muehlebach, Sarah A. Holstein
doaj   +1 more source

Identification of a novel signature based on unfolded protein response-related gene for predicting prognosis in bladder cancer

Human Genomics, 2021
Highlights 1. We first comprehensive investigated the expression, protein–protein interaction, and prognostic value of unfolded protein response-related gene in bladder cancer. 2.
Ke Zhu, Liu Xiaoqiang, Wen Deng, Gongxian Wang, Bin Fu   +4 more
doaj   +1 more source

Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1

Frontiers in Molecular Biosciences, 2019
The endoplasmic reticulum (ER) is an important site for protein folding and maturation in eukaryotes. The cellular requirement to synthesize proteins within the ER is matched by its folding capacity.
Christopher J. Adams, M. Kopp, Natacha Larburu, Piotr R. Nowak, Maruf M. U. Ali   +4 more
semanticscholar   +1 more source

Avaliação da ativação da via UPR (Unfolded Protein Response) em células de indivíduos HIV positivos sob diferentes esquemas terapêuticos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em BiotecnologiaA via UPR (do inglês Unfolded Protein Response) é uma resposta celular ao acúmulo de proteínas desenoveladas no ...
Borsa, Mariana
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration

Neuron, 2020
Summary Recent interest in astrocyte activation states has raised the fundamental question of how these cells, normally essential for synapse and neuronal maintenance, become pathogenic. Here, we show that activation of the unfolded protein response (UPR)
Heather L. Smith, O. Freeman, Adrian J. Butcher, S. Holmqvist, I. Humoud, Tobias Schätzl, Daniel T. Hughes, Nicholas C. Verity, Dean Swinden, Joseph Hayes, Lis de Weerd, D. Rowitch, R. Franklin, G. Mallucci   +13 more
semanticscholar   +1 more source