Results 81 to 90 of about 1,143,124 (339)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
IRE1-independent gain control of the unfolded protein response. [PDF]
PLoS Biology, 2004 Nonconventional splicing of the gene encoding the Hac1p transcription activator regulates the unfolded protein response (UPR) in Saccharomyces cerevisiae. This simple on/off switch contrasts with a more complex circuitry in higher eukaryotes.
Jess H Leber +2 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Therapy: Methods & Clinical Development, 2016 Factor VIII (FVIII) is a large glycoprotein that is challenging to express both in vitro and in vivo. Several studies suggest that high levels of FVIII expression can lead to cellular stress.
Amy M Lange +3 more
doaj +1 more source
Unfolded protein response, treatment and CMT1B [PDF]
Rare Diseases, 2013 CMT1B is the second most frequent autosomal dominant inherited neuropathy and is caused by assorted mutations of the myelin protein zero (MPZ) gene. MPZ mutations cause neuropathy gain of function mechanisms that are largely independent MPZs normal role of mediating myelin compaction.
Bai, Yunhong +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
eLife, 2016 Two mechanisms ensure that the mRNA encoding Hac1 protein, a transcription factor involved in the unfolded protein response, is only translated when it is needed.
David J Young, Nicholas R Guydosh
doaj +1 more source
ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response
iScience, 2020 Summary The unfolded protein response (UPR) pathway senses unfolded proteins and regulates proteostasis and cell fate through activity of the transcription factors ATF4, ATF6, and XBP1 within a complex network of three main branches.
Huan Yang +3 more
semanticscholar +1 more source
Avaliação da transcrição de grp78/bip em células de indivíduos HIV positivos sob diferentes esquemas terapêuticos [PDF]
, 2014 TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.retículo endoplasmático é responsável pela síntese, dobramento e algumas modificações de proteínas que serão secretadas ou proteínas de membrana.
Dahmer, Mariane
core
ROS and Endoplasmic Reticulum Stress in Pulmonary Disease
Frontiers in Pharmacology, 2022 Pulmonary diseases are main causes of morbidity and mortality worldwide. Current studies show that though specific pulmonary diseases and correlative lung-metabolic deviance own unique pathophysiology and clinical manifestations, they always tend to ...
Xiangning Cui +3 more
doaj +1 more source