Results 1 to 10 of about 46,487 (267)
PERK activation mitigates tau pathology in vitro and in vivo
EMBO Molecular Medicine, 2017 The RNA‐like endoplasmic reticulum kinase (PERK) is genetically associated with the tauopathy progressive supranuclear palsy (PSP). To elucidate the functional mechanisms underlying this association, we explored PERK activity in brains of PSP patients ...
Thomas W Rösler +2 more
exaly +2 more sources
Partial Deletion of Perk Improved High-Fat Diet-Induced Glucose Intolerance in Mice [PDF]
Endocrinology and Metabolism, 2023 Although pancreatic endoplasmic reticulum kinase (PERK) is indispensable to beta cells, low-dose PERK inhibitor improved glucose- stimulated insulin secretion (GSIS) and hyperglycemia in diabetic mice.
Jooyeop Lee +5 more
doaj +1 more source
Electroacupuncture reduces chronic fibromyalgia pain through attenuation of transient receptor potential vanilloid 1 signaling pathway in mouse brains [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Fibromyalgia pain is a mysterious clinical pain syndrome, characterized by inflammation in the brain, whose molecular mechanisms are still unknown.
Chia-Ming Yen +2 more
doaj +1 more source
Disease Models & Mechanisms, 2022 Misfolding of the prion protein (PrP) is responsible for devastating neurological disorders in humans and other mammals. An unresolved problem in the field is unraveling the mechanisms governing PrP conformational dynamics, misfolding, and the cellular ...
Ryan R. Myers +4 more
doaj +1 more source
Virulence, 2021 Endoplasmic reticulum stress (ERS)-mediated autophagy is indispensable for modulation of replication and pathogenesis of numerous mammalian viruses. We have previously shown that classical swine fever virus (CSFV) infection induces ERS-mediated autophagy
Erpeng Zhu +14 more
doaj +1 more source
Cells, 2022 High-fat diets (HFD) lead to impairment of chylomicrons (CMs) assembly and adversely influence intestinal lipid homeostasis. However, the mechanisms of HFD impairing CMs assembly have yet to be fully understood. Additionally, although choline, as a lipid-
Zhen-Yu Bai +5 more
doaj +1 more source
Viruses, 2020 The unfolded protein response (UPR) maintains protein-folding homeostasis in the endoplasmic reticulum (ER) and has been implicated as both beneficial and detrimental to flavivirus infection. Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)
Tyler G. Lewy +6 more
doaj +1 more source
Neuroprotective effect of a dietary supplement against glutamate-induced excitotoxicity in retina [PDF]
International Journal of Ophthalmology, 2019 AIM: To evaluate the neuroprotective effect of a dietary supplement (ClearVision EX®; CV) against glutamate-induced excitotoxicity in retina. METHODS: We evaluated the protective effects CV on glutamate-induced cell toxicity of an immortalized mouse ...
Takahiro Kurose +9 more
doaj +1 more source
CLINICAL AND DEMOGRAPHIC EVALUATION OF PATIENTS ADMITTED TO THE PEDIATRIC INTENSIVE CARE UNIT
Journal of Contemporary Medicine, 2022 Purpose: This study aimed to evaluate the patients who received health services in the pediatric intensive care unit (PICU) of Ankara City Hospital’s Pediatrics Department in a 2-year period and the outcomes of these cases by examining their clinical and
Oktay Perk
doaj +1 more source
Severe Wolcott-Rallison syndrome due to a nonsense mutation in the first exon EIF2AK3
Сахарный диабет, 2018 Wolcott-Rallison syndrome is a rare autosomal recessive disease characterized by neonatal diabetes mellitus in combination with osteodysplasia and liver failure.
Diliara N. Gubaeva +3 more
doaj +1 more source