PERK activation mitigates tau pathology in vitro and in vivo
EMBO Molecular Medicine, 2017 The RNA‐like endoplasmic reticulum kinase (PERK) is genetically associated with the tauopathy progressive supranuclear palsy (PSP). To elucidate the functional mechanisms underlying this association, we explored PERK activity in brains of PSP patients ...
Gunter Höglinger +2 more
exaly +4 more sources
PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma. [PDF]
PLoS Genetics, 2016 The unfolded protein response (UPR) regulates cell fate following exposure of cells to endoplasmic reticulum stresses. PERK, a UPR protein kinase, regulates protein synthesis and while linked with cell survival, exhibits activities associated with both ...
Dariusz Pytel +14 more
doaj +3 more sources
Inhibition of PERK signaling suppresses tumor progression and blocks GP73-GRP78-dependent stromal activation in hepatocellular carcinoma [PDF]
Neoplasia: An International Journal for Oncology ResearchEndoplasmic reticulum (ER) stress contributes to hepatocellular carcinoma (HCC) progression and promotes the development of a pro-tumorigenic microenvironment.
Jaafar Khaled +8 more
doaj +2 more sources
PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility.
PLoS ONE, 2016 PERK (EIF2AK3) is an ER-resident eIF2α kinase required for memory flexibility and metabotropic glutamate receptor-dependent long-term depression, processes known to be dependent on new protein synthesis. Here we investigated PERK's role in working memory,
Siying Zhu +3 more
doaj +2 more sources
Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling [PDF]
FEBS Open BioThe unfolded protein response (UPR) plays an important role in tumor progression and cellular stress adaptation. In hepatocellular carcinoma (HCC), pharmacological inhibition of the protein kinase R‐like endoplasmic reticulum kinase (PERK) is a potential
Ada Lerma‐Clavero +5 more
doaj +2 more sources
Partial Deletion of Perk Improved High-Fat Diet-Induced Glucose Intolerance in Mice [PDF]
Endocrinology and Metabolism, 2023 Although pancreatic endoplasmic reticulum kinase (PERK) is indispensable to beta cells, low-dose PERK inhibitor improved glucose- stimulated insulin secretion (GSIS) and hyperglycemia in diabetic mice.
Jooyeop Lee +5 more
doaj +1 more source
Electroacupuncture reduces chronic fibromyalgia pain through attenuation of transient receptor potential vanilloid 1 signaling pathway in mouse brains [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Fibromyalgia pain is a mysterious clinical pain syndrome, characterized by inflammation in the brain, whose molecular mechanisms are still unknown.
Chia-Ming Yen +2 more
doaj +1 more source
Disease Models & Mechanisms, 2022 Misfolding of the prion protein (PrP) is responsible for devastating neurological disorders in humans and other mammals. An unresolved problem in the field is unraveling the mechanisms governing PrP conformational dynamics, misfolding, and the cellular ...
Ryan R. Myers +4 more
doaj +1 more source
Virulence, 2021 Endoplasmic reticulum stress (ERS)-mediated autophagy is indispensable for modulation of replication and pathogenesis of numerous mammalian viruses. We have previously shown that classical swine fever virus (CSFV) infection induces ERS-mediated autophagy
Erpeng Zhu +14 more
doaj +1 more source
Cells, 2022 High-fat diets (HFD) lead to impairment of chylomicrons (CMs) assembly and adversely influence intestinal lipid homeostasis. However, the mechanisms of HFD impairing CMs assembly have yet to be fully understood. Additionally, although choline, as a lipid-
Zhen-Yu Bai +5 more
doaj +1 more source