Results 1 to 10 of about 60,696 (203)

PERK activation mitigates tau pathology in vitro and in vivo

EMBO Molecular Medicine, 2017
The RNA‐like endoplasmic reticulum kinase (PERK) is genetically associated with the tauopathy progressive supranuclear palsy (PSP). To elucidate the functional mechanisms underlying this association, we explored PERK activity in brains of PSP patients ...
Günter U Höglinger, Peer-Hendrik Kuhn, Thomas Arzberger   +2 more
exaly   +4 more sources

Partial Deletion of Perk Improved High-Fat Diet-Induced Glucose Intolerance in Mice [PDF]

Endocrinology and Metabolism, 2023
Although pancreatic endoplasmic reticulum kinase (PERK) is indispensable to beta cells, low-dose PERK inhibitor improved glucose- stimulated insulin secretion (GSIS) and hyperglycemia in diabetic mice.
Jooyeop Lee, Min Joo Kim, Seoil Moon, Ji Yoon Lim, Kyong Soo Park, Hye Seung Jung   +5 more
doaj   +3 more sources

Inhibition of PERK signaling suppresses tumor progression and blocks GP73-GRP78-dependent stromal activation in hepatocellular carcinoma [PDF]

Neoplasia: An International Journal for Oncology Research
Endoplasmic reticulum (ER) stress contributes to hepatocellular carcinoma (HCC) progression and promotes the development of a pro-tumorigenic microenvironment.
Jaafar Khaled, Maria Kopsida, Tania Payo-Serafín, Sofi Sennefelt Nyman, Fredrik Rorsman, Charlotte Ebeling Barbier, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +8 more
doaj   +2 more sources

Electroacupuncture reduces chronic fibromyalgia pain through attenuation of transient receptor potential vanilloid 1 signaling pathway in mouse brains [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Fibromyalgia pain is a mysterious clinical pain syndrome, characterized by inflammation in the brain, whose molecular mechanisms are still unknown.
Chia-Ming Yen, Ching-Liang Hsieh, Yi-Wen Lin   +2 more
doaj   +1 more source

New Drosophila models to uncover the intrinsic and extrinsic factors that mediate the toxicity of the human prion protein

Disease Models & Mechanisms, 2022
Misfolding of the prion protein (PrP) is responsible for devastating neurological disorders in humans and other mammals. An unresolved problem in the field is unraveling the mechanisms governing PrP conformational dynamics, misfolding, and the cellular ...
Ryan R. Myers, Jonatan Sanchez-Garcia, Daniel C. Leving, Richard G. Melvin, Pedro Fernandez-Funez   +4 more
doaj   +1 more source

Classical swine fever virus employs the PERK- and IRE1-dependent autophagy for viral replication in cultured cells.

Virulence, 2021
Endoplasmic reticulum stress (ERS)-mediated autophagy is indispensable for modulation of replication and pathogenesis of numerous mammalian viruses. We have previously shown that classical swine fever virus (CSFV) infection induces ERS-mediated autophagy
Erpeng Zhu, Huawei Wu, Wenxian Chen, Yuwei Qin, Jiameng Liu, Shuangqi Fan, Shengming Ma, Keke Wu, Qian Mao, Chaowei Luo, Yixian Qin, Lin Yi, Hongxing Ding, Mingqiu Zhao, Jinding Chen   +14 more
doaj   +1 more source

Dietary Choline Mitigates High-Fat Diet-Impaired Chylomicrons Assembly via UPRer Modulated by perk DNA Methylation

Cells, 2022
High-fat diets (HFD) lead to impairment of chylomicrons (CMs) assembly and adversely influence intestinal lipid homeostasis. However, the mechanisms of HFD impairing CMs assembly have yet to be fully understood. Additionally, although choline, as a lipid-
Zhen-Yu Bai, Hua Zheng, Zhi Luo, Christer Hogstrand, Ling-Jiao Wang, Yu-Feng Song   +5 more
doaj   +1 more source

PERK-Mediated Unfolded Protein Response Signaling Restricts Replication of the Tick-Borne Flavivirus Langat Virus

Viruses, 2020
The unfolded protein response (UPR) maintains protein-folding homeostasis in the endoplasmic reticulum (ER) and has been implicated as both beneficial and detrimental to flavivirus infection. Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)
Tyler G. Lewy, Danielle K. Offerdahl, Jeffrey M. Grabowski, Eliza Kellman, Luwanika Mlera, Abhilash Chiramel, Marshall E. Bloom   +6 more
doaj   +1 more source

Neuroprotective effect of a dietary supplement against glutamate-induced excitotoxicity in retina [PDF]

International Journal of Ophthalmology, 2019
AIM: To evaluate the neuroprotective effect of a dietary supplement (ClearVision EX®; CV) against glutamate-induced excitotoxicity in retina. METHODS: We evaluated the protective effects CV on glutamate-induced cell toxicity of an immortalized mouse ...
Takahiro Kurose, Eriko Sugano, Akihisa Sugai, Raki Shiraiwa, Mariyo Kato, Yoko Mitsuguchi, Yoshihiro Takai, Kitako Tabata, Yoichi Honma, Hiroshi Tomita   +9 more
doaj   +1 more source

Türk Ordusu İçin 1927-1928 Yıllarında Hazırlanan Bir Süvari Biniş Takımı Kataloğu

Erdem, 2019
Haluk Perk Müzesi Arşivinde yer alan ve Ahmet Cevdet İstanbul Saraçlık Fabrikası tarafından 20 Mayıs 1928 tarihinde hazırlanan askerî biniş ve koşum takımları kataloğu 54 sayfadan oluşmaktadır.
Savaş Volkan Genç, Haluk Perk
doaj   +1 more source