Results 41 to 50 of about 59,057 (299)

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions.

PLoS ONE, 2014
BackgroundInsulin synthesis and cell proliferation are under tight regulation in pancreatic β-cells to maintain glucose homeostasis. Dysfunction in either aspect leads to development of diabetes.
Rong Wang, Elyse E Munoz, Siying Zhu, Barbara C McGrath, Douglas R Cavener   +4 more
doaj   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Inhibition of PERK pathway enhances sensitivity of human osteosarcoma HOS cells induced to pyropheophorbide-a methyl ester-mediated photodynamic therapy

Di-san junyi daxue xuebao, 2019
Objective To explore the role of RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) pathway in the crosstalk of apoptosis and autophagy in human osteosarcoma HOS cells induced by pyropheophorbide-a methyl ester-mediated photodynamic ...
ZHONG Shenxi, OU Yunsheng, CHEN Yanyang, YU Haoyang, ZUO Qiang   +4 more
doaj   +1 more source

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

Predictive value of PERK and ATF6 mRNA and protein expression for liver metastasis after laparoscopic radical resection of colorectal cancer

结直肠肛门外科
[Objectives] To investigate the value of PERK and ATF6 mRNA and protein expression in predicting liver metastasis after laparoscopic radical resection of colorectal cancer.
Wang Yi, Zhang Dan, You Xiao
doaj   +1 more source

PERK Pathway Dataset.

, 2013
PERK Pathway Dataset.
Min-Ho Jung (363898), Susan Bonner-Weir (217167), Lorella Marselli (179072), Gordon C. Weir (245807), Allison B. Goldfine (363899), Jeffrey Kennedy (363896), Dennis Sgroi (363902), Hitoshi Katsuta (363897), Ulysses J. Balis (363901)   +8 more
core   +1 more source

PERK up! Resveratrol-Induced Stress Granules Involve PERK Pathway Activation.

, 2022
Resveratrol (Rsv) is a polyphenol produced by plants in response to cell stress and causes the formation of stress granules (SGs) at high doses. The formation of SGs often but not always results in downstream activation of the integrated stress response (
Staples, Meghan, Milks, Julia, Wall, Alexandra, Kola, Megi   +3 more
core   +3 more sources

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Theranostic Potential of an NAD(P)H‐Activatable Fluorophore: Assessing Cancer Aggressiveness and Triggering Apoptosis

Angewandte Chemie, EarlyView.
DE‐CQ, an NAD(P)H‐activatable theranostic probe, enables the quantification of cancer aggressiveness via glucose‐stimulated fluorescence imaging and selectively induces apoptosis. Its multifaceted efficacy is demonstrated across 2D cells, 3D spheroids, and in vivo models.
Yujin Cha, Taehoon Oh, Hui Joo Kim, Minju Kang, Shin A Yoon, Yul Lee, Yeon‐Ju Lee, Sun Young Park, Dong‐Sik Shin, Sung‐Kyun Ko, Jiyou Han, Min Hee Lee   +11 more
wiley   +2 more sources