Results 41 to 50 of about 60,696 (203)

Predictive value of PERK and ATF6 mRNA and protein expression for liver metastasis after laparoscopic radical resection of colorectal cancer

结直肠肛门外科
[Objectives] To investigate the value of PERK and ATF6 mRNA and protein expression in predicting liver metastasis after laparoscopic radical resection of colorectal cancer.
Wang Yi, Zhang Dan, You Xiao
doaj   +1 more source

TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress. [PDF]

PLoS ONE, 2014
Under ER stress, PKR-like ER-resident kinase (PERK) phosphorylates translation initiation factor eIF2α, resulting in repression of global protein synthesis and concomitant upregulation of the translation of specific mRNAs such as activating transcription
Yoshinori Tsukumo, Satomi Tsukahara, Aki Furuno, Shun-ichiro Iemura, Toru Natsume, Akihiro Tomida   +5 more
doaj   +1 more source

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury: PERK as a potential target for intervention

Neural Regeneration Research
Several studies have shown that activation of unfolded protein response and endoplasmic reticulum (ER) stress plays a crucial role in severe cerebral ischemia/reperfusion injury. Autophagy occurs within hours after cerebral ischemia, but the relationship
Ju Zheng, Yixin Li, Ting Zhang, Yanlin Fu, Peiyan Long, Xiao Gao, Zhengwei Wang, Zhizhong Guan, Xiaolan Qi, Wei Hong, Yan Xiao   +10 more
doaj   +1 more source

Elucidating the Prognostic Role of BRAFV600E and the Activation Status of the Downstream MAPK Pathway in PTC: A Study from a Tertiary Centre in India

Indian Journal of Endocrinology and Metabolism
Introduction: Papillary thyroid carcinoma (PTC) has an excellent prognosis, but few cases are treatment-resistant. To check the applicability of combined BRAFV600E and MEK-targeted therapy, the current study correlated BRAFV600E with the MAPK pathway ...
Nadeem Kocheri, Priti Chatterjee, Shipra Agarwal, Mehar C. Sharma, Sanjana Ballal, Chandrasekhar Bal, Sunil Chumber   +6 more
doaj   +1 more source

Interactome Analysis of the ER Stress Sensor Perk Uncovers Key Components of ER-Mitochondria Contact Sites and Ca Signalling

Contact, 2021
We recently reported that the ER stress kinase PERK regulates ER-mitochondria appositions and ER– plasma membrane (ER-PM) contact sites, independent of its canonical role in the unfolded protein response. PERK regulation of ER-PM contacts was revealed by
Maria Livia Sassano, Rita Derua, Etienne Waelkens, Patrizia Agostinis, Alexander R van Vliet   +4 more
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Insulin production was modulated by Perk during development.

, 2014
A. Total pancreatic insulin content of Perk+/− mice relative to Perk+/+ during postnatal development. Shown are means ± SEM (n for Perk +/−, Perk+/+  =  14, 16 (P5); 8,5 (P17); 18, 16 (P30); 10, 15 (P50); 8, 6 (P180 ...
Elyse E. Munoz (575799), Barbara C. McGrath (210345), Douglas R. Cavener (210348), Rong Wang (59795), Siying Zhu (459098)   +4 more
core   +1 more source

Research Progress of Endoplasmic Reticulum Stress PERK-eIF2α-AFT4-CHOP Signaling Pathway in Hematological Malignancies

Zhongliu Fangzhi Yanjiu
The biosynthesis and maturation of proteins are primarily regulated by the endoplasmic reticulum in its physiological state. Thus, the disruption of physiological homeostasis initiates the buildup of unfolded and misfolded proteins in the endoplasmic ...
HE Mengke, XU Zizhen, LI Junmin
doaj   +1 more source

Characterization of a tumor-derived mutation of the PERK kinase.

, 2017
A) Depection of melanoma-derived PERK mutations. B-D) Western analysis of MEF lysates expressing murine versions of Perk alleles tested under ER-stress conditions.
Yan Gao (93649), Serge Y. Fuchs (217962), Ireneusz Majsterek (3558608), Meenhard Herlyn (291309), Olga S. Chajewski (3558605), Akihiro Yoshida (713605), Dariusz Pytel (3558602), Maria C. G. Paredes (3558617), Kirk A. Staschke (569568), Yuliya V. Katlinskaya (3558614), J. Alan Diehl (3109995), Katarzyna Mackiewicz (362448), Shuo Qie (3110010), Gao Zhang (660886), Lawrence Wu (3558611)   +14 more
core   +1 more source

High glucose causes apoptosis of rabbit corneal epithelial cells involving activation of PERK-eIF2α-CHOP-caspase-12 signaling pathway [PDF]

International Journal of Ophthalmology, 2019
AIM: To investigate the effect of high concentration of glucose (HCG) on double stranded RNA-activated protein kinase-like ER kinase (PERK)-eukaryotic initiation factor-2α (eIF2α)-transcription factor C/EBP homologous protein (CHOP)-cysteine aspartate ...
Pan-Pan Yao, Min-Jie Sheng, Wen-Hao Weng, Yin Long, Hao Liu, Li Chen, Jia-Jun Lu, Ao Rong, Bing Li   +8 more
doaj   +1 more source

Xrp1 expression is induced at the upstream of PERK.

, 2021
(A) Xrp1-lacZ/+ background wing disc bearing hsFLP-induced GFP-labeled clones of RpL14/+, salE>GFP + PERK-RNAi cells stained with anti-β-gal. (B) Xrp1-lacZ/+ background eye disc bearing eyFLP-induced MARCM clones of Hel25E-/- + PERK RNAi cells stained ...
Ryosuke Nakano (4557097), Tatsushi Igaki (10047238), Mai Nakamura (634579), Rina Nagata (11797964), Naotaka Ochi (11797961), Naoki Wakasa (11797967)   +5 more
core   +1 more source