Results 21 to 30 of about 60,696 (203)
Complex V knockdown activates the Integrated Stress Response through PERK.
, 2023 (a) Schematic of Drosophila eIF2α kinases. Amino acid deprivation or endoplasmic reticulum (ER) stress activate either GCN2 or PERK, respectively. Both kinases dimerize and phosphorylate eIF2α.
Vernon Leander Monteiro (14504887) +3 more
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PERK-dependent eIF2α phosphorylation during the KSHV lytic cycle.
, 2019 TREx BCBL1-RTA cells were treated with 1 μg/mL dox -/+ 500 nM of the PERK inhibitor GSK2606414 (PERKi) for 0, 24 and 48 h and treated with or without 75 nM Thapsisgargin (Tg) for 2 h prior to harvest.
Craig McCormick (451471) +2 more
core +1 more source
PERK pathway activation in heart.
, 2014 The protein levels of p-PERK, PERK, p-eIF2α, eIF2α.
Hanpeng Huang (549638) +6 more
core +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2020 Xiaohui Xu,1,2,* Biao Chen,3,* Qichun Huang,1 Yani Wu,4 Tao Liang5 1Department of Pharmacy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China; 2Institute of Cancer Prevention and Treatment ...
Xu X, Chen B, Huang Q, Wu Y, Liang T
doaj
Development of a cell-free screening assay for the identification of direct PERK activators.
PLoS ONE, 2023 The activation of the unfolded protein response, particularly via the PERK pathway, has been suggested as a promising therapeutic approach in tauopathies, a group of neurodegenerative disorders characterized by the abnormal phosphorylation and ...
Márcia F D Costa +2 more
doaj +1 more source
Modulation of Perk dosage using Perk+/− mice impacted glucose homeostasis.
, 2014 A. Random fed serum glucose of mice at 15–36 postnatal days. Mice are in mixed genetic background.
Elyse E. Munoz (575799) +4 more
core +1 more source
Scientific Reports, 2021 Endoplasmic reticulum (ER) stress plays an important role in hepatocyte degeneration, especially in patients with chronic liver injury. Protein kinase R-like endoplasmic reticulum kinase (PERK) is a key molecule in ER stress.
Atsushi Yukimoto +10 more
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PTP1B dephosphorylation of PERK.
, 2012 (A) PERK was immunoprecipitated from BAT lysates of Cre, fl/fl and adipose-PTP1B KO (KO) male mice fed HFD for 30 weeks, and then immunoblotted with anti-phosphotyrosine antibodies, phospho-specific antibodies for PKR Tyr293 (PERK Y615) and PERK (Thr980).
Kosuke Matsuo (68494) +6 more
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PERK and filamin A in actin cytoskeleton remodeling at ER-plasma membrane contact sites
Molecular & Cellular Oncology, 2017 The endoplasmic reticulum (ER) stress sensor protein kinase RNA-like endoplasmic reticulum kinase (PERK) plays a major role during the unfolded protein response (UPR), mainly through eIF2α phosphorylation.
Alexander R. van Vliet +1 more
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The Prognostic Value of PERK in Cancer and Its Relationship With Immune Cell Infiltration
Frontiers in Molecular Biosciences, 2021 Background: Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is a type I transmembrane protein that functions as an endoplasmic reticulum (ER) stress sensor to regulate global protein synthesis.
Peng Wang +6 more
doaj +1 more source