Results 21 to 30 of about 59,057 (299)

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

eLife, 2015
The unfolded protein response (UPR) is an essential cell signaling system that detects the accumulation of misfolded proteins within the endoplasmic reticulum (ER) and initiates a cellular response in order to maintain homeostasis.
Marta Carrara, Filippo Prischi, Piotr R Nowak, Megan C Kopp, Maruf MU Ali   +4 more
doaj   +1 more source

Molecular mechanisms involved in endoplasmic reticulum stress development: What do we know today [PDF]

Medicinski Podmladak
Endoplasmic reticulum (ER) is an intracellular organelle involved in protein synthesis and folding. When the balance between cell needs for proteins and ER capacity to fold proteins is disrupted, nonfunctional, unfolded, or misfolded proteins accumulate ...
Vidičević-Novaković Sašenka, Stanojević Željka   +1 more
doaj   +1 more source

Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation [PDF]

, 2022
Tauopathies are neurodegenerative diseases caused by pathologic misfolded tau protein aggregation in the nervous system. Population studies implicate EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3), better known as PERK (protein ...
Park, Goonho, Kim, Kyle, Safarta, Lance, Lin, Jonathan H, Xu, Ke, Wu, Jian, Song, Keon-Hyoung, Hiramatsu, Nobuhiko, Chea, Leon, Lin, Jonathan H., Min, Hyejung, Park, Soyoung, Han, Jaeseok   +12 more
core   +1 more source

The Reflection of Positivism to German Literature / Pozitivizmin Alman Edebiyatına Yansıması [PDF]

Folklor/Edebiyat, 2018
Towards the end of the19th century, there had been many social and economic changes and these changes had effects upon the public which could be regarded as negative.
Derya Perk
doaj   +1 more source

PERK-dependent eIF2α phosphorylation during the KSHV lytic cycle.

, 2019
TREx BCBL1-RTA cells were treated with 1 μg/mL dox -/+ 500 nM of the PERK inhibitor GSK2606414 (PERKi) for 0, 24 and 48 h and treated with or without 75 nM Thapsisgargin (Tg) for 2 h prior to harvest.
Craig McCormick (451471), Eric S. Pringle (8067485), Benjamin P. Johnston (8067482)   +2 more
core   +1 more source

The Effects of Puerarin on Autophagy Through Regulating of the PERK/eIF2α/ATF4 Signaling Pathway Influences Renal Function in Diabetic Nephropathy

Diabetes, Metabolic Syndrome and Obesity, 2020
Xiaohui Xu,1,2,* Biao Chen,3,* Qichun Huang,1 Yani Wu,4 Tao Liang5 1Department of Pharmacy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China; 2Institute of Cancer Prevention and Treatment ...
Xu X, Chen B, Huang Q, Wu Y, Liang T
doaj  

The long noncoding RNA of RMRP is downregulated by PERK, which induces apoptosis in hepatocellular carcinoma cells

Scientific Reports, 2021
Endoplasmic reticulum (ER) stress plays an important role in hepatocyte degeneration, especially in patients with chronic liver injury. Protein kinase R-like endoplasmic reticulum kinase (PERK) is a key molecule in ER stress.
Atsushi Yukimoto, Takao Watanabe, Kotaro Sunago, Yoshiko Nakamura, Takaaki Tanaka, Yohei Koizumi, Osamu Yoshida, Yoshio Tokumoto, Masashi Hirooka, Masanori Abe, Yoichi Hiasa   +10 more
doaj   +1 more source

PTP1B dephosphorylation of PERK.

, 2012
(A) PERK was immunoprecipitated from BAT lysates of Cre, fl/fl and adipose-PTP1B KO (KO) male mice fed HFD for 30 weeks, and then immunoblotted with anti-phosphotyrosine antibodies, phospho-specific antibodies for PKR Tyr293 (PERK Y615) and PERK (Thr980).
Kosuke Matsuo (68494), Ramzi Melhem (173125), Ahmed Bettaieb (173694), Antonis E. Koromilas (173709), Izumi Matsuo (173701), Shuo Wang (143908), Fawaz G. Haj (162534)   +6 more
core   +1 more source

Development of a cell-free screening assay for the identification of direct PERK activators.

PLoS ONE, 2023
The activation of the unfolded protein response, particularly via the PERK pathway, has been suggested as a promising therapeutic approach in tauopathies, a group of neurodegenerative disorders characterized by the abnormal phosphorylation and ...
Márcia F D Costa, Günter U Höglinger, Thomas W Rösler   +2 more
doaj   +1 more source

Ralph J. Perk, the “New ethnicity”, and the making of urban ethnic republicans [PDF]

, 2017
Historians seeking to explain the late twentieth century rightward shift of urban ethnic whites have tended to ignore the shifting meaning and content of white ethnic identity in this transition, and the utility of these changes to conservative political
JOE MERTON, Merton, Joe
core   +1 more source