QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF-κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis. [PDF]
Adv Sci (Weinh)QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Li H +9 more
europepmc +2 more sources
Vorläufiges Verzeichnis zum schriftlichen Teilnachlass Gotthard Liebchen (1906-1956) - Mscr.Dresd.App.Liebchen [PDF]
, 2020 Zusammengestellt von Perk Loesch im April ...
Loesch, Perk
core +3 more sources
Viruses, 2020 The unfolded protein response (UPR) maintains protein-folding homeostasis in the endoplasmic reticulum (ER) and has been implicated as both beneficial and detrimental to flavivirus infection. Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)
Tyler G. Lewy +6 more
doaj +1 more source
Neuroprotective effect of a dietary supplement against glutamate-induced excitotoxicity in retina [PDF]
International Journal of Ophthalmology, 2019 AIM: To evaluate the neuroprotective effect of a dietary supplement (ClearVision EX®; CV) against glutamate-induced excitotoxicity in retina. METHODS: We evaluated the protective effects CV on glutamate-induced cell toxicity of an immortalized mouse ...
Takahiro Kurose +9 more
doaj +1 more source
Türk Ordusu İçin 1927-1928 Yıllarında Hazırlanan Bir Süvari Biniş Takımı Kataloğu
Erdem, 2019 Haluk Perk Müzesi Arşivinde yer alan ve Ahmet Cevdet İstanbul Saraçlık Fabrikası tarafından 20 Mayıs 1928 tarihinde hazırlanan askerî biniş ve koşum takımları kataloğu 54 sayfadan oluşmaktadır.
Savaş Volkan Genç, Haluk Perk
doaj +1 more source
CLINICAL AND DEMOGRAPHIC EVALUATION OF PATIENTS ADMITTED TO THE PEDIATRIC INTENSIVE CARE UNIT
Journal of Contemporary Medicine, 2022 Purpose: This study aimed to evaluate the patients who received health services in the pediatric intensive care unit (PICU) of Ankara City Hospital’s Pediatrics Department in a 2-year period and the outcomes of these cases by examining their clinical and
Oktay Perk
doaj +1 more source
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy. [PDF]
Adv Sci (Weinh)Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Xu H +17 more
europepmc +2 more sources
pERK score in urothelial tumors.
, 2021 (A) Representative photographs of pERK immunohistochemistry (original magnification 400×) from each category are shown. (B) pERK staining intensity was evaluated and scored (0–5), and pERK score in each category was shown (N: non-tumor; n = 101, P ...
Li Chunning (11752069) +6 more
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A short history of the European Association of Preventive Cardiology (EAPC) [PDF]
, 2022 De Backer G, Perk J, Wood D, et al. A short history of the European Association of Preventive Cardiology (EAPC). European Journal of Preventive Cardiology .
Gielen, Stephan +15 more
core +1 more source
Severe Wolcott-Rallison syndrome due to a nonsense mutation in the first exon EIF2AK3
Сахарный диабет, 2018 Wolcott-Rallison syndrome is a rare autosomal recessive disease characterized by neonatal diabetes mellitus in combination with osteodysplasia and liver failure.
Diliara N. Gubaeva +3 more
doaj +1 more source