PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility.
PLoS ONE, 2016 PERK (EIF2AK3) is an ER-resident eIF2α kinase required for memory flexibility and metabotropic glutamate receptor-dependent long-term depression, processes known to be dependent on new protein synthesis. Here we investigated PERK's role in working memory,
Siying Zhu +3 more
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PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma. [PDF]
PLoS Genetics, 2016 The unfolded protein response (UPR) regulates cell fate following exposure of cells to endoplasmic reticulum stresses. PERK, a UPR protein kinase, regulates protein synthesis and while linked with cell survival, exhibits activities associated with both ...
Dariusz Pytel +14 more
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Genetic knock-in of EIF2AK3 variants reveals differences in PERK activity in mouse liver and pancreas under endoplasmic reticulum stress [PDF]
Scientific ReportsCommon single-nucleotide variants (SNVs) of eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3) slightly increase the risk of disorders in the periphery and the central nervous system.
Shivesh Ghura +6 more
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ER stress tolerance is regulated by copper-dependent PERK kinase activity
Cell ReportsSummary: Pancreatic/PKR-like endoplasmic reticulum (ER) kinase (PERK) is a kinase that, in response to ER stress, mediates dual homeostatic and pro-apoptotic signaling. Thus, intricate regulation is required for physiological function.
Sarah E. Bond Newton +9 more
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Vorläufiges Verzeichnis zum schriftlichen Teilnachlass Gotthard Liebchen (1906-1956) - Mscr.Dresd.App.Liebchen [PDF]
, 2020 Zusammengestellt von Perk Loesch im April ...
Loesch, Perk
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Severe Wolcott-Rallison syndrome due to a nonsense mutation in the first exon EIF2AK3
Сахарный диабет, 2018 Wolcott-Rallison syndrome is a rare autosomal recessive disease characterized by neonatal diabetes mellitus in combination with osteodysplasia and liver failure.
Diliara N. Gubaeva +3 more
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eLife, 2015 The unfolded protein response (UPR) is an essential cell signaling system that detects the accumulation of misfolded proteins within the endoplasmic reticulum (ER) and initiates a cellular response in order to maintain homeostasis.
Marta Carrara +4 more
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CLINICAL AND DEMOGRAPHIC EVALUATION OF PATIENTS ADMITTED TO THE PEDIATRIC INTENSIVE CARE UNIT
Journal of Contemporary Medicine, 2022 Purpose: This study aimed to evaluate the patients who received health services in the pediatric intensive care unit (PICU) of Ankara City Hospital’s Pediatrics Department in a 2-year period and the outcomes of these cases by examining their clinical and
Oktay Perk
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Molecular mechanisms involved in endoplasmic reticulum stress development: What do we know today [PDF]
Medicinski PodmladakEndoplasmic reticulum (ER) is an intracellular organelle involved in protein synthesis and folding. When the balance between cell needs for proteins and ER capacity to fold proteins is disrupted, nonfunctional, unfolded, or misfolded proteins accumulate ...
Vidičević-Novaković Sašenka +1 more
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The Reflection of Positivism to German Literature / Pozitivizmin Alman Edebiyatına Yansıması [PDF]
Folklor/Edebiyat, 2018 Towards the end of the19th century, there had been many social and economic changes and these changes had effects upon the public which could be regarded as negative.
Derya Perk
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