Results 1 to 10 of about 1,308,915 (353)

ER Stress-Sensor Proteins and ER-Mitochondrial Crosstalk—Signaling Beyond (ER) Stress Response [PDF]

Biomolecules, 2021
Recent studies undoubtedly show the importance of inter organellar connections to maintain cellular homeostasis. In normal physiological conditions or in the presence of cellular and environmental stress, each organelle responds alone or in coordination ...
Vaishali Kumar, Shuvadeep Maity
doaj   +3 more sources

Targeting ER stress/ER stress response in myopathies

Redox Biology, 2019
There is more skeletal muscle tissue in the body than any other tissue and, as it is the organ of the majority of metabolic activity, muscle defect can affect the health of the entire body.
Ester Zito
doaj   +4 more sources

Reticulons Regulate the ER Inheritance Block during ER Stress [PDF]

Developmental Cell, 2016
Segregation of functional organelles during the cell cycle is crucial to generate healthy daughter cells. In Saccharomyces cerevisiae, ER stress causes an ER inheritance block to ensure cells inherit a functional ER. Here, we report that formation of tubular ER in the mother cell, the first step in ER inheritance, depends on functional symmetry between
Francisco Piña, Tinya C. Fleming, Kit Pogliano, Maho Niwa   +3 more
openalex   +5 more sources

Enhancing ER stress in myeloma

Aging, 2017
Refereed/Peer ...
Craig T. Wallington‐Beddoe, Stuart M. Pitson   +1 more
openalex   +4 more sources

Evaluation of taVNS for extreme environments: an exploration study of health benefits and stress operationality

Frontiers in Neurology, 2023
IntroductionLong-duration space missions will be a real challenge for maintaining astronauts' adaptability. Research on transcutaneous vagus nerve stimulation (taVNS) is expanding rapidly, and its modalities constitute a major research challenge.
Barbara Le Roy, Barbara Le Roy, Barbara Le Roy, Charles Martin-Krumm, Charles Martin-Krumm, Charles Martin-Krumm, Adèle Gille, Sandrine Jacob, Cécile Vigier, Sylvain Laborde, Sylvain Laborde, Damien Claverie, Stéphane Besnard, Stéphane Besnard, Marion Trousselard, Marion Trousselard, Marion Trousselard   +16 more
doaj   +1 more source

Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

The EMBO Journal, 2023
Intestinal goblet cells are secretory cells specialized in the production of mucins, and as such are challenged by the need for efficient protein folding.
Eva Cloots, Phaedra Guilbert, Mathias Provost, Lisa Neidhardt, Evelien Van de Velde, Farzaneh Fayazpour, Delphine De Sutter, Savvas N Savvides, Sven Eyckerman, Sophie Janssens   +9 more
doaj   +1 more source

Sugarcoating ER Stress [PDF]

Cell, 2014
The hexosamine biosynthetic pathway (HBP) generates metabolites for protein N- and O-glycosylation. Wang et al. and Denzel et al. report a hitherto unknown link between the HBP and stress in the endoplasmic reticulum. These studies establish the HBP as a critical component of the cellular machinery of protein homeostasis.
Lisa Vincenz, F.Ulrich Hartl
openaire   +3 more sources

Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection

iScience, 2023
Summary: The unfolded protein response (UPR) aims to restore ER homeostasis under conditions of high protein folding load, a function primarily serving secretory cells. Additional, non-canonical UPR functions have recently been unraveled in immune cells.
Jessica Vetters, Mary van Helden, Clint De Nolf, Sofie Rennen, Eva Cloots, Evelien Van De Velde, Farzaneh Fayazpour, Justine Van Moorleghem, Manon Vanheerswynghels, Karl Vergote, Louis Boon, Eric Vivier, Bart N. Lambrecht, Sophie Janssens   +13 more
doaj   +1 more source

IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland. [PDF]

, 2013
We recently reported that the PPM1l gene encodes an endoplasmic reticulum (ER) membrane targeted protein phosphatase (named PP2Ce) with highly specific activity towards Inositol-requiring protein-1 (IRE1) and regulates the functional outcome of ER stress.
Lane, Timothy F, Lu, Gang, Ota, Asuka, Ren, Shuxun, Vondriska, Thomas M, Wang, Yibin, Zhou, Z Hong   +6 more
core   +12 more sources

The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

The EMBO Journal, 2023
Effector mechanisms of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) are well-characterised, but how ER proteostasis is sensed is less well understood.
Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding, Stephen H McLaughlin, Sophie Janssens, David Ron   +7 more
doaj   +1 more source