Results 21 to 30 of about 1,308,915 (353)

The endoplasmic reticulum in plant immunity and cell death [PDF]

, 2012
The endoplasmic reticulum (ER) is a highly dynamic organelle in eukaryotic cells and a major production site of proteins destined for vacuoles, the plasma membrane, or apoplast in plants.
Eichmann, Ruth, Schäfer, P. (Patrick)
core   +2 more sources

Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. [PDF]

, 2015
Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid highly abundant in copra/palmist oils, is a predictor of nonalcoholic steatohepatitis (NASH) and
Alarcón-Vila, C, Baulies, A, Caballeria, J, Casas, J, Elena, M, Fabriàs, G, Fernandez-Checa, JC, García-Ruiz, C, Martinez Gili, L, Torres, S   +9 more
core   +5 more sources

Cell Death Signaling From Endoplasmic Reticulum Stress: Plant-Specific and Conserved Features

Frontiers in Plant Science, 2022
The endoplasmic reticulum (ER) stress response is triggered by any condition that disrupts protein folding and promotes the accumulation of unfolded proteins in the lumen of the organelle.
Eduardo B. Simoni, Célio C. Oliveira, Otto T. Fraga, Pedro A. B. Reis, Elizabeth P. B. Fontes   +4 more
doaj   +1 more source

Dexmedetomidine Alleviated Endoplasmic Reticulum Stress via Inducing ER-phagy in the Spinal Cord of Neuropathic Pain Model

Frontiers in Neuroscience, 2020
Studies demonstrated that spinal autophagy was impaired in spinal nerve ligation (SNL) rats. However, the relationship of endoplasmic reticulum (ER) stress and ER-phagy and whether dexmedetomidine (DEX) modulates ER-phagy remain unclear.
Yongda Liu, Yongda Liu, Shuang Wang, Zhibin Wang, Zhibin Wang, Mengmeng Ding, Mengmeng Ding, Xingyue Li, Xingyue Li, Jiao Guo, Jiao Guo, Guang Han, Guang Han, Ping Zhao, Ping Zhao   +14 more
doaj   +1 more source

ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death. [PDF]

PLoS ONE, 2017
Disruption of protein folding in the endoplasmic reticulum (ER) causes ER stress. Activation of the unfolded protein response (UPR) acts to restore protein homeostasis or, if ER stress is severe or persistent, drive apoptosis, which is thought to proceed
Nicola J Darling, Kathryn Balmanno, Simon J Cook   +2 more
doaj   +1 more source

Androgens impair β-cell function in a mouse model of polycystic ovary syndrome by activating endoplasmic reticulum stress

Endocrine Connections, 2021
Background: Androgens excess results in endoplasmic reticulum (ER) stress, which is an important cause of β cells dysfunction. Here, we investigated the molecular regulation of androgens excess, ER stress, and β-cell function in polycystic ovary syndrome
Bo Zhu, Yumei Chen, Fang Xu, Xiaolu Shen, Xuanyu Chen, Jieqiang Lv, Songying Zhang   +6 more
doaj   +1 more source

Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation. [PDF]

, 2017
Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusceptible regions ...
Bailey, Keith A, Haj, Fawaz G, Passerini, Anthony G, Simon, Scott I   +3 more
core   +1 more source

Endoplasmic reticulum stress: a novel targeted approach to repair bone defects by regulating osteogenesis and angiogenesis

Journal of Translational Medicine, 2023
Bone regeneration therapy is clinically important, and targeted regulation of endoplasmic reticulum (ER) stress is important in regenerative medicine. The processing of proteins in the ER controls cell fate.
Tingyu Wu, Yaping Jiang, Weipeng Shi, Yingzhen Wang, Tao Li   +4 more
doaj   +1 more source

Roles and Therapeutic Implications of Endoplasmic Reticulum Stress and Oxidative Stress in Cardiovascular Diseases

Antioxidants, 2021
In different pathological states that cause endoplasmic reticulum (ER) calcium depletion, altered glycosylation, nutrient deprivation, oxidative stress, DNA damage or energy perturbation/fluctuations, the protein folding process is disrupted and the ER ...
Yan Zhou, Dharmani Devi Murugan, Haroon Khan, Yu Huang, Wai San Cheang   +4 more
doaj   +1 more source

ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. [PDF]

, 2018
BACKGROUND: Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER stress, as well as the accumulation ...
Fu, Z, Hu, Q, Ke, X, Li, P, Liu, Y, Sun, J, Tan, Z, Wang, H, Zhang, W, Zhang, Y, Zheng, C, Zheng, Z   +11 more
core   +1 more source