Results 31 to 40 of about 40,852 (216)

The mutualistic fungus Piriformospora indica colonizes Arabidopsis roots by inducing an endoplasmic reticulum stress-triggered caspase-dependent cell death [PDF]

, 2012
In Arabidopsis thaliana roots, the mutualistic fungus Piriformospora indica initially colonizes living cells, which die as the colonization proceeds. We aimed to clarify the molecular basis of this colonization-associated cell death.
Zechmann, B., Kogel, Karl-Heinz, Schäfer, Patrick, Qiang, X., Reitz, M. U.   +4 more
core   +1 more source

Endoplasmic reticulum stress as target for treatment of hearing loss

STEMedicine, 2020
The endoplasmic reticulum (ER) plays pivotal roles in coordinating protein biosynthesis and processing. Under ER stress, when excessive misfolded or unfolded proteins are accumulated in the ER, the unfolded protein response (UPR) is activated.
Yanfei Wang, Zhigang Xu
doaj   +1 more source

Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases [PDF]

PeerJ, 2020
Objective Endoplasmic reticulum (ER) stress is involved in the pathogenesis of various ophthalmic diseases, and ER stress-mediated degradation systems play an important role in maintaining ER homeostasis during ER stress. The purpose of this review is to
Jing-Yao Song, Xue-Guang Wang, Zi-Yuan Zhang, Lin Che, Bin Fan, Guang-Yu Li   +5 more
doaj   +2 more sources

Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise [PDF]

, 2013
Pathological endoplasmic reticulum (ER) stress is tightly linked to the accumulation of reactive oxidants, which can be both upstream and downstream of ER stress.
Julia Birk, Thomas Ramming, Alex Odermatt, Julia eBirk, Thomas eRamming, Alex eOdermatt, Birk, Julia, Christian eAppenzeller-Herzog, Ramming, Thomas, Appenzeller-Herzog, Christian, Odermatt, Alex, Christian Appenzeller-Herzog   +11 more
core   +1 more source

EFP1 is an ER stress-induced glycoprotein which interacts with the pro-apoptotic protein Par-4

, 2009
We have isolated the rat ortholog of EFP1 (EF-hand binding protein 1) as a novel interaction partner of the pro-apoptotic protein Par-4 (prostate apoptosis response-4).
Maertens, Barbara, Koplin, Ansgar, Appel, Sarah, Preuss, Ute, Vetterkind, Susanne, Boosen, Meike   +5 more
core   +1 more source

Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]

, 2011
Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
core   +1 more source

EDEM depletion mitigates ER stress.

, 2022
(A) Representative confocal images of WT(EV) control or indicated RNAi depleted young adults carrying the Phsp-4::GFP transgene under non ER-stress conditions (upper panel), treatment with 5 μg/ml tunicamycin for 12h (middle panel), and heat shock, and 5
Marioara Chiritoiu (12119830), Antonio Miranda-Vizuete (231674), Robi Tacutu (123994), Chiritoiu, Marioara, Stefana Maria Petrescu (12119833), Miranda-Vizuete, Antonio, Tacutu, Robi, Petrescu, Stefana Maria, Simona Ghenea (144823), Ghenea, Simona   +9 more
core   +1 more source

Deep Learning-Based Morphological Classification of Endoplasmic Reticulum Under Stress

Frontiers in Cell and Developmental Biology, 2022
Endoplasmic reticulum stress (ER stress) is a condition that is defined by abnormal accumulation of unfolded proteins. It plays an important role in maintaining cellular protein, lipid, and ion homeostasis.
Yuanhao Guo, Yuanhao Guo, Di Shen, Yanfeng Zhou, Yanfeng Zhou, Yutong Yang, Jinzhao Liang, Yating Zhou, Yating Zhou, Ningning Li, Yu Liu, Ge Yang, Ge Yang, Wenjing Li, Wenjing Li   +14 more
doaj   +1 more source

ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta [PDF]

, 2008
Osteogenesis imperfecta is an inherited disorder characterized by increased bone fragility, fractures, and osteoporosis, and most cases are caused by mutations affecting the type I collagen genes.
Ralston, Stuart H., Thomas S Lisse, Eckhard Wolf, Quintanilla-Martinez Leticia, de Angelis Martin Hrabé, Fuchs Helmut, Lisse Thomas S, Gabriele Hoelzlwimmer, Hrabě de Angelis, M., Martin Hrabé de Angelis, Hölzlwimmer, G., Abe, Koichiro, Rathkolb, Birgit, de Angelis, Martin Hrabe, Hans, Wolfgang, Rathkolb, B., Quintanilla-Martinez, Leticia, Ralston, Stuart H, Koichiro Abe, Abe, K., Wolf Eckhard, Przemeck, G.K.H., Hans Wolfgang, Hoelzlwimmer, Gabriele, Przemeck Gerhard K. H, Fuchs, H., Abe Koichiro, Hoelzlwimmer Gabriele, Hrabé de Angelis, Martin, Wolf, E., Miep Helfrich, Lisse, Thomas S, Quintanilla-Martinez, L., Thiele, F., Ralston, S.H., Helmut Fuchs, Gerhard K H Przemeck, Helfrich, M., Helfrich, Miep, Przemeck, Gerhard K. H., Lisse, Thomas S., Thiele, Frank, Frank Thiele, Helfrich Miep, Stuart H Ralston, Wolfgang Hans, Hans, W., Przemeck, Gerhard K H, Thiele Frank, Rathkolb Birgit, Ralston Stuart H, Lisse, T.S., Birgit Rathkolb, Fuchs, Helmut, Wolf, Eckhard, Leticia Quintanilla-Martinez   +55 more
core   +1 more source

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Cell Reports
Summary: Depending on how antigens are being decoded by dendritic cells (DCs), their acquisition will induce a homeostatic or immunogenic maturation program.
Sofie Rennen, Victor Bosteels, Clint De Nolf, Sandra Maréchal, Jessica Vetters, Karo Van Lil, Greta Webb, Janne Swinnen, Evelien Van De Velde, Farzaneh Fayazpour, Ria Roelandt, Niels Vandamme, Kevin Verstaen, Stefaan C. De Smedt, Karine Breckpot, Stijn Vanhee, Philippe Gevaert, Eric Hoste, Bruno G. De Geest, Rein Verbeke, Ine Lentacker, Sophie Janssens   +21 more
doaj   +1 more source