Results 31 to 40 of about 233,384 (263)
Frontiers in Neuroscience, 2020 Studies demonstrated that spinal autophagy was impaired in spinal nerve ligation (SNL) rats. However, the relationship of endoplasmic reticulum (ER) stress and ER-phagy and whether dexmedetomidine (DEX) modulates ER-phagy remain unclear.
Yongda Liu +14 more
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Endocrine Connections, 2021 Background: Androgens excess results in endoplasmic reticulum (ER) stress, which is an important cause of β cells dysfunction. Here, we investigated the molecular regulation of androgens excess, ER stress, and β-cell function in polycystic ovary syndrome
Bo Zhu +6 more
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Journal of Translational Medicine, 2023 Bone regeneration therapy is clinically important, and targeted regulation of endoplasmic reticulum (ER) stress is important in regenerative medicine. The processing of proteins in the ER controls cell fate.
Tingyu Wu +4 more
doaj +1 more source
Endoplasmic Reticulum Stress and Reactive Oxygen Species in Plants
Antioxidants, 2022 The endoplasmic reticulum (ER) is a key compartment responsible for protein processing and folding, and it also participates in many signal transduction and metabolic processes. Reactive oxygen species (ROS) are important signaling messengers involved in
Jiajian Cao +4 more
doaj +1 more source
ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death. [PDF]
PLoS ONE, 2017 Disruption of protein folding in the endoplasmic reticulum (ER) causes ER stress. Activation of the unfolded protein response (UPR) acts to restore protein homeostasis or, if ER stress is severe or persistent, drive apoptosis, which is thought to proceed
Nicola J Darling +2 more
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Antioxidants, 2021 In different pathological states that cause endoplasmic reticulum (ER) calcium depletion, altered glycosylation, nutrient deprivation, oxidative stress, DNA damage or energy perturbation/fluctuations, the protein folding process is disrupted and the ER ...
Yan Zhou +4 more
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Stress management at the ER: Regulators of ER stress-induced apoptosis
Pharmacology & Therapeutics, 2012 The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins which are detected by ER transmembrane receptors that initiate the unfolded protein response (UPR) to restore normal ER function.
Gorman, Adrienne M. +3 more
openaire +3 more sources
A NODding acquaintance with ER stress [PDF]
Cell Death Discovery, 2016 Accumulation of unfolded or misfolded proteins in the lumen of the endoplasmatic reticulum (ER) results in ER stress and induces the unfolded protein response (UPR). The UPR consists of distinct cellular processes, such as increased transcription of repair proteins and chaperones, cell death and the induction of an inflammatory response resulting in ...
Stafford, CA, Nachbur, U
openaire +3 more sources
MFN2 mediates ER-mitochondrial coupling during ER stress through specialized stable contact sites
Frontiers in Cell and Developmental Biology, 2022 Endoplasmic reticulum (ER) functions critically depend on a suitable ATP supply to fuel ER chaperons and protein trafficking. A disruption of the ability of the ER to traffic and fold proteins leads to ER stress and the unfolded protein response (UPR ...
Benjamin Gottschalk +6 more
doaj +1 more source
The genetic architecture of the genome-wide transcriptional response to ER stress in the mouse.
PLoS Genetics, 2015 Endoplasmic reticulum (ER) stress occurs when misfolded proteins accumulate in the ER. The cellular response to ER stress involves complex transcriptional and translational changes, important to the survival of the cell.
Clement Y Chow +4 more
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