Results 31 to 40 of about 225,463 (263)

The genetic architecture of the genome-wide transcriptional response to ER stress in the mouse.

PLoS Genetics, 2015
Endoplasmic reticulum (ER) stress occurs when misfolded proteins accumulate in the ER. The cellular response to ER stress involves complex transcriptional and translational changes, important to the survival of the cell.
Clement Y Chow, Xu Wang, David Riccardi, Mariana F Wolfner, Andrew G Clark   +4 more
doaj   +1 more source

ER-Phagy and ER Stress Response (ERSR) in Plants [PDF]

Frontiers in Plant Science, 2019
The endoplasmic reticulum (ER) is the starting point for protein secretion and lipid biosynthesis in eukaryotes. ER homeostasis is precisely regulated by the unfolded protein response (UPR) to alleviate stress, involving both transcriptional and translational regulators.
Yonglun Zeng, Baiying Li, Wenxin Zhang, Liwen Jiang, Liwen Jiang   +4 more
openaire   +3 more sources

Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases [PDF]

PeerJ, 2020
Objective Endoplasmic reticulum (ER) stress is involved in the pathogenesis of various ophthalmic diseases, and ER stress-mediated degradation systems play an important role in maintaining ER homeostasis during ER stress. The purpose of this review is to
Jing-Yao Song, Xue-Guang Wang, Zi-Yuan Zhang, Lin Che, Bin Fan, Guang-Yu Li   +5 more
doaj   +2 more sources

Rab7a modulates ER stress and ER morphology

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2018
The Endoplasmic Reticulum (ER) is a membranous organelle with diverse structural and functional domains. Peripheral ER includes interconnected tubules, and dense tubular arrays called "ER matrices" together with bona fide flat cisternae. Transitions between these states are regulated by membrane-associated proteins and cytosolic factors.
Duarte, Mateus, Elettra Sara, Marini, Cinzia, Progida, Oddmund, Bakke   +3 more
openaire   +2 more sources

Endoplasmic reticulum stress as target for treatment of hearing loss

STEMedicine, 2020
The endoplasmic reticulum (ER) plays pivotal roles in coordinating protein biosynthesis and processing. Under ER stress, when excessive misfolded or unfolded proteins are accumulated in the ER, the unfolded protein response (UPR) is activated.
Yanfei Wang, Zhigang Xu
doaj   +1 more source

Reciprocal regulation between ER stress and autophagy in renal tubular fibrosis and apoptosis

Cell Death and Disease, 2021
Both endoplasmic reticulum (ER) stress and autophagy have been implicated in chronic kidney injury and renal fibrosis. However, the relationship and regulatory mechanisms between ER stress and autophagy under this condition remain largely unknown.
Shaoqun Shu, Hui Wang, Jiefu Zhu, Zhiwen Liu, Danyi Yang, Wenwen Wu, Juan Cai, Anqun Chen, Chengyuan Tang, Zheng Dong   +9 more
doaj   +1 more source

Deep Learning-Based Morphological Classification of Endoplasmic Reticulum Under Stress

Frontiers in Cell and Developmental Biology, 2022
Endoplasmic reticulum stress (ER stress) is a condition that is defined by abnormal accumulation of unfolded proteins. It plays an important role in maintaining cellular protein, lipid, and ion homeostasis.
Yuanhao Guo, Yuanhao Guo, Di Shen, Yanfeng Zhou, Yanfeng Zhou, Yutong Yang, Jinzhao Liang, Yating Zhou, Yating Zhou, Ningning Li, Yu Liu, Ge Yang, Ge Yang, Wenjing Li, Wenjing Li   +14 more
doaj   +1 more source

Obesity and endoplasmic reticulum (ER) stresses [PDF]

Frontiers in Immunology, 2012
In obesity, the adipose cells behave as inflammatory source and result to low grade inflammation. This systemic inflammation along with oxidative stress is a silent killer and damages other vital organs also. High metabolic process, induced due to high nutritional intake, results to endoplasmic reticulum (ER) stress and mitochondrial stress.
Tripathi, Yamini B., Pandey, Vivek
openaire   +3 more sources

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Cell Reports
Summary: Depending on how antigens are being decoded by dendritic cells (DCs), their acquisition will induce a homeostatic or immunogenic maturation program.
Sofie Rennen, Victor Bosteels, Clint De Nolf, Sandra Maréchal, Jessica Vetters, Karo Van Lil, Greta Webb, Janne Swinnen, Evelien Van De Velde, Farzaneh Fayazpour, Ria Roelandt, Niels Vandamme, Kevin Verstaen, Stefaan C. De Smedt, Karine Breckpot, Stijn Vanhee, Philippe Gevaert, Eric Hoste, Bruno G. De Geest, Rein Verbeke, Ine Lentacker, Sophie Janssens   +21 more
doaj   +1 more source

NCLs and ER: A stressful relationship

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017
The Neuronal Ceroid Lipofuscinoses (NCLs, Batten disease) are a group of inherited neurodegenerative disorders with variable age of onset, characterized by the lysosomal accumulation of autofluorescent ceroid lipopigments. The endoplasmic reticulum (ER) is a critical organelle for normal cell function. Alteration of ER homeostasis leads to accumulation
Marotta, Davide, Tinelli, Elisa, Mole, Sara E.   +2 more
openaire   +3 more sources