Endoplasmic Reticulum Stress and Reactive Oxygen Species in Plants
Antioxidants, 2022 The endoplasmic reticulum (ER) is a key compartment responsible for protein processing and folding, and it also participates in many signal transduction and metabolic processes. Reactive oxygen species (ROS) are important signaling messengers involved in
Jiajian Cao +4 more
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IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress [PDF]
, 2020 IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress.
Acosta-Alvear +54 more
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MFN2 mediates ER-mitochondrial coupling during ER stress through specialized stable contact sites
Frontiers in Cell and Developmental Biology, 2022 Endoplasmic reticulum (ER) functions critically depend on a suitable ATP supply to fuel ER chaperons and protein trafficking. A disruption of the ability of the ER to traffic and fold proteins leads to ER stress and the unfolded protein response (UPR ...
Benjamin Gottschalk +6 more
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Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress. [PDF]
, 2017 Sirtuin1 (Sirt1) is a class III histone deacetylase that regulates a variety of physiological processes, including endothelial function. Caveolin1 (Cav1) is also an important determinant of endothelial function. We asked if Sirt1 governs endothelial Cav1
Gabani, Mohanad +10 more
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Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress-Mediated Cell Death and Fetal Loss via Type IV Secretion System-Dependent Activation of CHOP. [PDF]
, 2019 Subversion of endoplasmic reticulum (ER) function is a feature shared by multiple intracellular bacteria and viruses, and in many cases this disruption of cellular function activates pathways of the unfolded protein response (UPR).
Atluri, Vidya L +14 more
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Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]
, 2011 Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
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MicroRNA-494 Regulates Endoplasmic Reticulum Stress in Endothelial Cells
Frontiers in Cell and Developmental Biology, 2021 Defects in stress responses are important contributors in many chronic conditions including cancer, cardiovascular disease, diabetes, and obesity-driven pathologies like non-alcoholic steatohepatitis (NASH).
Namita Chatterjee +5 more
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Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]
, 2013 It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin +6 more
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The genetic architecture of the genome-wide transcriptional response to ER stress in the mouse.
PLoS Genetics, 2015 Endoplasmic reticulum (ER) stress occurs when misfolded proteins accumulate in the ER. The cellular response to ER stress involves complex transcriptional and translational changes, important to the survival of the cell.
Clement Y Chow +4 more
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Endoplasmic reticulum stress as target for treatment of hearing loss
STEMedicine, 2020 The endoplasmic reticulum (ER) plays pivotal roles in coordinating protein biosynthesis and processing. Under ER stress, when excessive misfolded or unfolded proteins are accumulated in the ER, the unfolded protein response (UPR) is activated.
Yanfei Wang, Zhigang Xu
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