Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways
Cell ReportsSummary: Depending on how antigens are being decoded by dendritic cells (DCs), their acquisition will induce a homeostatic or immunogenic maturation program.
Sofie Rennen +21 more
doaj +1 more source
Reciprocal regulation between ER stress and autophagy in renal tubular fibrosis and apoptosis
Cell Death and Disease, 2021 Both endoplasmic reticulum (ER) stress and autophagy have been implicated in chronic kidney injury and renal fibrosis. However, the relationship and regulatory mechanisms between ER stress and autophagy under this condition remain largely unknown.
Shaoqun Shu +9 more
doaj +1 more source
Endothelial cells, endoplasmic reticulum stress and oxysterols [PDF]
, 2017 Oxysterols are bioactive lipids that act as regulators of lipid metabolism, inflammation, cell viability and are involved in several diseases, including atherosclerosis.
Canonico, B. +10 more
core +3 more sources
The World Journal of Men's Health, 2020 Endoplasmic reticulum (ER) stress, defined as prolonged disturbances in protein folding and accumulation of unfolded proteins in the ER. Perturbation of the ER, such as distribution of oxidative stress, iron imbalance, Ca2+ leakage, protein overload ...
Keshab Kumar Karna +4 more
doaj +1 more source
Deep Learning-Based Morphological Classification of Endoplasmic Reticulum Under Stress
Frontiers in Cell and Developmental Biology, 2022 Endoplasmic reticulum stress (ER stress) is a condition that is defined by abnormal accumulation of unfolded proteins. It plays an important role in maintaining cellular protein, lipid, and ion homeostasis.
Yuanhao Guo +14 more
doaj +1 more source
Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. [PDF]
, 2018 Background & aimsHeavy alcohol drinking is associated with pancreatitis, whereas moderate intake lowers the risk. Mice fed ethanol long term show no pancreas damage unless adaptive/protective responses mediating proteostasis are disrupted. Pancreatic
Abrol, Ravinder +13 more
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Obesity and endoplasmic reticulum (ER) stresses [PDF]
Frontiers in Immunology, 2012 In obesity, the adipose cells behave as inflammatory source and result to low grade inflammation. This systemic inflammation along with oxidative stress is a silent killer and damages other vital organs also. High metabolic process, induced due to high nutritional intake, results to endoplasmic reticulum (ER) stress and mitochondrial stress.
Tripathi, Yamini B., Pandey, Vivek
openaire +3 more sources
HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response. [PDF]
PLoS ONE, 2011 BACKGROUND: The endoplasmic reticulum (ER) is the cellular site for protein folding. ER stress occurs when protein folding capacity is exceeded. This stress induces a cyto-protective signaling cascades termed the unfolded protein response (UPR) aimed at ...
Emmanuelle Merquiol +7 more
doaj +1 more source
Regulation of endoplasmic reticulum stress in models of kidney disease
Advances in Redox Research, 2021 Endoplasmic reticulum (ER) stress is induced by intrinsic and extrinsic factors and, in consequence, activates the unfolded protein response (UPR); which in an acute phase restores cellular homeostasis, whereas in a chronic phase promotes apoptosis.
Tania Gómez-Sierra +4 more
doaj +1 more source
Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes [PDF]
, 2018 Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Allard, Camille +12 more
core +2 more sources