Results 71 to 80 of about 40,852 (216)

ER stress and hepatic lipid metabolism

Frontiers in Genetics, 2014
The endoplasmic reticulum (ER) is an important player in regulating protein synthesis and lipid metabolism. Perturbation of ER homeostasis, referred as ER stress, has been linked to numerous pathological conditions, such as inflammation, cardiovascular ...
Huiping eZhou, Huiping eZhou, Runping eLiu   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Concerted Transport and Phosphorylation of Diacylglycerol at ER-PM Contacts Sites Regulates Phospholipid Dynamics During Stress [PDF]

A universal response of plants to environmental stresses is the activation of plasma membrane (PM) phospholipase C (PLC) that hydrolyzes phosphatidylinositol phosphate (PIP) to produce soluble inositol phosphate (IP) and diacylglycerol (DAG).
Amorim-Silva, V., Markovic, V., Catala, R., Jaillais, Y., Michaelson, L. V., Haslam, R. P., Botella, M. A., Napier, J. A., Ruiz-Lopez, N., Salinas, J., Garcia-Hernandez, S., Moya-Cuevas, J.   +11 more
core   +1 more source

When Supply Does Not Meet Demand-ER Stress and Plant Programmed Cell Death [PDF]

, 2014
The endoplasmic reticulum (ER) is the central organelle in the eukaryotic secretory pathway. The ER functions in protein synthesis and maturation and is crucial for proper maintenance of cellular homeostasis and adaptation to adverse environments. Acting
Williams, Brett, Martin eDickman, Jeanmarie eVerchot, Verchot, Jeanmarie, Dickman, Martin B., Brett eWilliams   +5 more
core   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Cellular stress responses: cell survival and cell death [PDF]

, 2010
Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells.
Afshin Samali, Hori, Osamu, Gorman, Adrienne M., 26106, Fulda, Simone, 26105, Samali, Afshin, 26107, 60303947, 233, Simone Fulda, Osamu Hori, Adrienne M. Gorman   +12 more
core   +1 more source

The Role of Endoplasmic Reticulum Stress in Cardiovascular Disease and Exercise

International Journal of Vascular Medicine, 2017
Endoplasmic reticulum (ER) stress, which is highly associated with cardiovascular disease, is triggered by a disturbance in ER function because of protein misfolding or an increase in protein secretion.
Junyoung Hong, Kwangchan Kim, Jong-Hee Kim, Yoonjung Park   +3 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Drosophila REEP1 modulates ER morphology and ER stress

, 2019
Defects in endoplasmic reticulum (ER) membrane shaping and in lipid metabolism seem to be crucial mechanisms underlying Hereditary Spastic Paraplegia (HSP), a complex genetic disorder characterized by the axonal degeneration of corticospinal tracts. Here
ForgiariniA., De Martin S., Martinuzzi A., Orso G., Gumeni S., Fantin M., Napoli B., Montopoli M.   +7 more
core  

Detecting Autophagy in Response to ER Stress Signals in Cancer

, 2011
Different physiological and pathological situations that produce alterations in the endoplasmic reticulum, lead to a condition known as ER stress. ER stress activates a complex intracellular signal transduction pathway, called unfolded protein response ...
Mar Lorente, Sonia Hernández-Tiedra, Guzmán Pastor, Manuel, María Salazar, Guillermo Velasco, Hernández Tiedra, Sonia, Lorente Pérez, María Del Mar, Sofía Torres, Manuel Guzmán, Torres, Sofía, Velasco Díez, Guillermo, Salazar Roa, María   +11 more
core   +1 more source